Effects of phenytoin and carbamazepine on human natural killer cell activity and genotoxicity in vitro

Human peripheral blood mononuclear cells (PBMC) were isolated from healthy volunteers and exposed in vitro to phenytoin or carbamazepine, two widely used antiepileptic drugs (AED). This study investigated the effects of these drugs on natural killer (NK) cell activity and antibody-dependent cell-med...

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Veröffentlicht in:	Toxicology and applied pharmacology 1987, Vol.87 (1), p.10-17
Hauptverfasser:	Margaretten, Nadine C., Hincks, Jeffrey R., Warren, Reed P., Coulombe, Roger A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody-Dependent Cell Cytotoxicity - drug effects Biological and medical sciences Carbamazepine - toxicity DNA, Single-Stranded - drug effects Drug toxicity and drugs side effects treatment Humans Hydrogen-Ion Concentration In Vitro Techniques Killer Cells, Natural - drug effects Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Monocytes - drug effects Pharmacology. Drug treatments Phenytoin - toxicity
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