Nutlin-3 inhibits epithelial–mesenchymal transition by interfering with canonical transforming growth factor-β1-Smad-Snail/Slug axis
Highlights • EMT caused by TGF-β1 could be inhibited by Nutlin-3 in p53-null tumor cells. • The mechanism relies on the prohibitive effect of Nutlin-3 on Smads pathway. • Nutlin-3 exhibited noticeable suppressive activity against cell migration. • EGFRIs could be sensitized by combination with Nutli...
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| Veröffentlicht in: | Cancer letters 2014-01, Vol.342 (1), p.82-91 |
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| container_start_page | 82 |
| container_title | Cancer letters |
| container_volume | 342 |
| creator | Wu, Yeping Fu, Yingying Zheng, Lin Lin, Guanyu Ma, Jian Lou, Jianshu Zhu, Hong He, Qiaojun Yang, Bo |
| description | Highlights • EMT caused by TGF-β1 could be inhibited by Nutlin-3 in p53-null tumor cells. • The mechanism relies on the prohibitive effect of Nutlin-3 on Smads pathway. • Nutlin-3 exhibited noticeable suppressive activity against cell migration. • EGFRIs could be sensitized by combination with Nutlin-3 with TGF-β1 treatment. |
| doi_str_mv | 10.1016/j.canlet.2013.08.039 |
| format | Article |
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Fu, Yingying ; Zheng, Lin ; Lin, Guanyu ; Ma, Jian ; Lou, Jianshu ; Zhu, Hong ; He, Qiaojun ; Yang, Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-9de9ed5cbc1a99398c11e6eeb7faed07c22dc404d3e596f1c95f1a6d6166032a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antineoplastic Agents - pharmacology</topic><topic>Cadherins - genetics</topic><topic>Cadherins - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - drug effects</topic><topic>Drug Evaluation, Preclinical</topic><topic>Drug Synergism</topic><topic>EMT</topic><topic>Epithelial-Mesenchymal Transition - drug effects</topic><topic>Gene Expression - drug effects</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Imidazoles - pharmacology</topic><topic>Nutlin-3</topic><topic>Phosphorylation</topic><topic>Piperazines - pharmacology</topic><topic>Protein Kinase Inhibitors - pharmacology</topic><topic>Protein Processing, Post-Translational</topic><topic>Quinazolines - pharmacology</topic><topic>Receptor, Epidermal Growth Factor - antagonists & inhibitors</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Signal Transduction - drug effects</topic><topic>Smad pathway</topic><topic>Smad Proteins - metabolism</topic><topic>Snail Family Transcription Factors</topic><topic>TGF-β1</topic><topic>Transcription Factors - metabolism</topic><topic>Transforming Growth Factor beta1 - physiology</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Yeping</creatorcontrib><creatorcontrib>Fu, Yingying</creatorcontrib><creatorcontrib>Zheng, Lin</creatorcontrib><creatorcontrib>Lin, Guanyu</creatorcontrib><creatorcontrib>Ma, Jian</creatorcontrib><creatorcontrib>Lou, Jianshu</creatorcontrib><creatorcontrib>Zhu, Hong</creatorcontrib><creatorcontrib>He, Qiaojun</creatorcontrib><creatorcontrib>Yang, Bo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Yeping</au><au>Fu, Yingying</au><au>Zheng, Lin</au><au>Lin, Guanyu</au><au>Ma, Jian</au><au>Lou, Jianshu</au><au>Zhu, Hong</au><au>He, Qiaojun</au><au>Yang, Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nutlin-3 inhibits epithelial–mesenchymal transition by interfering with canonical transforming growth factor-β1-Smad-Snail/Slug axis</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>342</volume><issue>1</issue><spage>82</spage><epage>91</epage><pages>82-91</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Highlights • EMT caused by TGF-β1 could be inhibited by Nutlin-3 in p53-null tumor cells. • The mechanism relies on the prohibitive effect of Nutlin-3 on Smads pathway. • Nutlin-3 exhibited noticeable suppressive activity against cell migration. • EGFRIs could be sensitized by combination with Nutlin-3 with TGF-β1 treatment.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>24001610</pmid><doi>10.1016/j.canlet.2013.08.039</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2014-01, Vol.342 (1), p.82-91 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antineoplastic Agents - pharmacology Cadherins - genetics Cadherins - metabolism Cell Line, Tumor Cell Movement - drug effects Drug Evaluation, Preclinical Drug Synergism EMT Epithelial-Mesenchymal Transition - drug effects Gene Expression - drug effects Hematology, Oncology and Palliative Medicine Humans Imidazoles - pharmacology Nutlin-3 Phosphorylation Piperazines - pharmacology Protein Kinase Inhibitors - pharmacology Protein Processing, Post-Translational Quinazolines - pharmacology Receptor, Epidermal Growth Factor - antagonists & inhibitors RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects Smad pathway Smad Proteins - metabolism Snail Family Transcription Factors TGF-β1 Transcription Factors - metabolism Transforming Growth Factor beta1 - physiology Up-Regulation |
| title | Nutlin-3 inhibits epithelial–mesenchymal transition by interfering with canonical transforming growth factor-β1-Smad-Snail/Slug axis |
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