Differential Longitudinal Decline on the Mini-Mental State Examination in Frontotemporal Lobar Degeneration and Alzheimer Disease
OBJECTIVE:To examine how phenotype affects longitudinal decline on the Mini-Mental State Examination (MMSE) in patients with frontotemporal lobar degeneration (FTLD) and Alzheimer disease (AD). BACKGROUND:The MMSE is the most commonly administered assessment for dementia severity; however, the effec...
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| Veröffentlicht in: | Alzheimer disease and associated disorders 2013-10, Vol.27 (4), p.310-315 |
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| creator | Tan, Kay See Libon, David J Rascovsky, Katya Grossman, Murray Xie, Sharon X |
| description | OBJECTIVE:To examine how phenotype affects longitudinal decline on the Mini-Mental State Examination (MMSE) in patients with frontotemporal lobar degeneration (FTLD) and Alzheimer disease (AD).
BACKGROUND:The MMSE is the most commonly administered assessment for dementia severity; however, the effects of phenotype on longitudinal MMSE performance in FTLD and AD have not been extensively studied.
METHODS:Data from 185 patients diagnosed with AD (n=106) and 3 FTLD (n=79) phenotypes [behavioral variant frontotemporal dementia (bvFTD), nonfluent agrammatic variant of primary progressive aphasia (nfaPPA), and semantic variant PPA (svPPA)] were collected for up to 52 months since initial evaluation.
RESULTS:Differential rates of decline were noted in that MMSE scores declined more precipitously for AD and svPPA compared with bvFTD and nfaPPA patients (P=0.001). The absolute 4-year MMSE decline given median baseline MMSE for bvFTD [14.67; 95% confidence interval (CI), 14.63-14.71] and nfaPPA (11.02; 95% CI, 10.98-11.06) were lower than svPPA (22.32; 95% CI, 22.29-22.34) or AD (22.24; 95% CI, 22.22-22.26).
CONCLUSIONS:These data suggest that within-group AD and FTLD phenotypes present distinct patterns of longitudinal decline on the MMSE. MMSE may not be adequately sensitive to track disease progression in some phenotypes of FTLD. |
| doi_str_mv | 10.1097/WAD.0b013e31827bdc6f |
| format | Article |
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BACKGROUND:The MMSE is the most commonly administered assessment for dementia severity; however, the effects of phenotype on longitudinal MMSE performance in FTLD and AD have not been extensively studied.
METHODS:Data from 185 patients diagnosed with AD (n=106) and 3 FTLD (n=79) phenotypes [behavioral variant frontotemporal dementia (bvFTD), nonfluent agrammatic variant of primary progressive aphasia (nfaPPA), and semantic variant PPA (svPPA)] were collected for up to 52 months since initial evaluation.
RESULTS:Differential rates of decline were noted in that MMSE scores declined more precipitously for AD and svPPA compared with bvFTD and nfaPPA patients (P=0.001). The absolute 4-year MMSE decline given median baseline MMSE for bvFTD [14.67; 95% confidence interval (CI), 14.63-14.71] and nfaPPA (11.02; 95% CI, 10.98-11.06) were lower than svPPA (22.32; 95% CI, 22.29-22.34) or AD (22.24; 95% CI, 22.22-22.26).
CONCLUSIONS:These data suggest that within-group AD and FTLD phenotypes present distinct patterns of longitudinal decline on the MMSE. MMSE may not be adequately sensitive to track disease progression in some phenotypes of FTLD.</description><identifier>ISSN: 0893-0341</identifier><identifier>EISSN: 1546-4156</identifier><identifier>DOI: 10.1097/WAD.0b013e31827bdc6f</identifier><identifier>PMID: 23314064</identifier><identifier>CODEN: ADADE2</identifier><language>eng</language><publisher>Hagerstown, MD: by Lippincott Williams & Wilkins</publisher><subject>Adult and adolescent clinical studies ; Aged ; Alzheimer Disease - diagnosis ; Alzheimer Disease - psychology ; Biological and medical sciences ; Brief Psychiatric Rating Scale ; Cohort Studies ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Progression ; Female ; Follow-Up Studies ; Frontotemporal Lobar Degeneration - diagnosis ; Frontotemporal Lobar Degeneration - psychology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Nervous system ; Neurology ; Neuropsychological Tests ; Organic mental disorders. Neuropsychology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Single-Blind Method</subject><ispartof>Alzheimer disease and associated disorders, 2013-10, Vol.27 (4), p.310-315</ispartof><rights>2013 by Lippincott Williams & Wilkins.</rights><rights>2015 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432f-c716075c5a69a5d36c202d7162bae71353e5ca6eea687262386914d87cf07ffd3</citedby><cites>FETCH-LOGICAL-c432f-c716075c5a69a5d36c202d7162bae71353e5ca6eea687262386914d87cf07ffd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28014632$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23314064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Kay See</creatorcontrib><creatorcontrib>Libon, David J</creatorcontrib><creatorcontrib>Rascovsky, Katya</creatorcontrib><creatorcontrib>Grossman, Murray</creatorcontrib><creatorcontrib>Xie, Sharon X</creatorcontrib><title>Differential Longitudinal Decline on the Mini-Mental State Examination in Frontotemporal Lobar Degeneration and Alzheimer Disease</title><title>Alzheimer disease and associated disorders</title><addtitle>Alzheimer Dis Assoc Disord</addtitle><description>OBJECTIVE:To examine how phenotype affects longitudinal decline on the Mini-Mental State Examination (MMSE) in patients with frontotemporal lobar degeneration (FTLD) and Alzheimer disease (AD).
BACKGROUND:The MMSE is the most commonly administered assessment for dementia severity; however, the effects of phenotype on longitudinal MMSE performance in FTLD and AD have not been extensively studied.
METHODS:Data from 185 patients diagnosed with AD (n=106) and 3 FTLD (n=79) phenotypes [behavioral variant frontotemporal dementia (bvFTD), nonfluent agrammatic variant of primary progressive aphasia (nfaPPA), and semantic variant PPA (svPPA)] were collected for up to 52 months since initial evaluation.
RESULTS:Differential rates of decline were noted in that MMSE scores declined more precipitously for AD and svPPA compared with bvFTD and nfaPPA patients (P=0.001). The absolute 4-year MMSE decline given median baseline MMSE for bvFTD [14.67; 95% confidence interval (CI), 14.63-14.71] and nfaPPA (11.02; 95% CI, 10.98-11.06) were lower than svPPA (22.32; 95% CI, 22.29-22.34) or AD (22.24; 95% CI, 22.22-22.26).
CONCLUSIONS:These data suggest that within-group AD and FTLD phenotypes present distinct patterns of longitudinal decline on the MMSE. MMSE may not be adequately sensitive to track disease progression in some phenotypes of FTLD.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - psychology</subject><subject>Biological and medical sciences</subject><subject>Brief Psychiatric Rating Scale</subject><subject>Cohort Studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Frontotemporal Lobar Degeneration - diagnosis</subject><subject>Frontotemporal Lobar Degeneration - psychology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Single-Blind Method</subject><issn>0893-0341</issn><issn>1546-4156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EosvCP0AoF6ReUvzt5LjqtoC0FQdAHCPHGXcNjr3Yjgrc-OcYdgGJAydrPM-8M3oQekrwBcG9evFhs73AIyYMGOmoGicj7T20IoLLlhMh76MV7nrWYsbJGXqU80eMsWICP0RnlDHCseQr9H3rrIUEoTjtm10Mt64skwu12ILxLkATQ1P20Ny44NqbCtbW26ILNFdf9FzJ4irhQnOdYiixwHyI6VfWqFMNuYUA6QjpMDUb_20Pbobachl0hsfogdU-w5PTu0bvr6_eXb5qd29evr7c7FrDGbWtUURiJYzQstdiYtJQTKf6SUcNijDBQBgtAbTsFJWUdbInfOqUsVhZO7E1Oj_mHlL8vEAuw-yyAe91gLjkgXDRC8lYdbZG_IiaFHNOYIdDcrNOXweCh5_yhyp_-Fd-HXt22rCMM0x_hn7brsDzE6Cz0d4mHYzLf7kOEy4ZrVx35O6iL5DyJ7_cQRr2oH3Z__-GH-3dojs</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Tan, Kay See</creator><creator>Libon, David J</creator><creator>Rascovsky, Katya</creator><creator>Grossman, Murray</creator><creator>Xie, Sharon X</creator><general>by Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>Differential Longitudinal Decline on the Mini-Mental State Examination in Frontotemporal Lobar Degeneration and Alzheimer Disease</title><author>Tan, Kay See ; Libon, David J ; Rascovsky, Katya ; Grossman, Murray ; Xie, Sharon X</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432f-c716075c5a69a5d36c202d7162bae71353e5ca6eea687262386914d87cf07ffd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - psychology</topic><topic>Biological and medical sciences</topic><topic>Brief Psychiatric Rating Scale</topic><topic>Cohort Studies</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Frontotemporal Lobar Degeneration - diagnosis</topic><topic>Frontotemporal Lobar Degeneration - psychology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Single-Blind Method</topic><toplevel>online_resources</toplevel><creatorcontrib>Tan, Kay See</creatorcontrib><creatorcontrib>Libon, David J</creatorcontrib><creatorcontrib>Rascovsky, Katya</creatorcontrib><creatorcontrib>Grossman, Murray</creatorcontrib><creatorcontrib>Xie, Sharon X</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alzheimer disease and associated disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Kay See</au><au>Libon, David J</au><au>Rascovsky, Katya</au><au>Grossman, Murray</au><au>Xie, Sharon X</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Longitudinal Decline on the Mini-Mental State Examination in Frontotemporal Lobar Degeneration and Alzheimer Disease</atitle><jtitle>Alzheimer disease and associated disorders</jtitle><addtitle>Alzheimer Dis Assoc Disord</addtitle><date>2013-10</date><risdate>2013</risdate><volume>27</volume><issue>4</issue><spage>310</spage><epage>315</epage><pages>310-315</pages><issn>0893-0341</issn><eissn>1546-4156</eissn><coden>ADADE2</coden><abstract>OBJECTIVE:To examine how phenotype affects longitudinal decline on the Mini-Mental State Examination (MMSE) in patients with frontotemporal lobar degeneration (FTLD) and Alzheimer disease (AD).
BACKGROUND:The MMSE is the most commonly administered assessment for dementia severity; however, the effects of phenotype on longitudinal MMSE performance in FTLD and AD have not been extensively studied.
METHODS:Data from 185 patients diagnosed with AD (n=106) and 3 FTLD (n=79) phenotypes [behavioral variant frontotemporal dementia (bvFTD), nonfluent agrammatic variant of primary progressive aphasia (nfaPPA), and semantic variant PPA (svPPA)] were collected for up to 52 months since initial evaluation.
RESULTS:Differential rates of decline were noted in that MMSE scores declined more precipitously for AD and svPPA compared with bvFTD and nfaPPA patients (P=0.001). The absolute 4-year MMSE decline given median baseline MMSE for bvFTD [14.67; 95% confidence interval (CI), 14.63-14.71] and nfaPPA (11.02; 95% CI, 10.98-11.06) were lower than svPPA (22.32; 95% CI, 22.29-22.34) or AD (22.24; 95% CI, 22.22-22.26).
CONCLUSIONS:These data suggest that within-group AD and FTLD phenotypes present distinct patterns of longitudinal decline on the MMSE. MMSE may not be adequately sensitive to track disease progression in some phenotypes of FTLD.</abstract><cop>Hagerstown, MD</cop><pub>by Lippincott Williams & Wilkins</pub><pmid>23314064</pmid><doi>10.1097/WAD.0b013e31827bdc6f</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Alzheimer disease and associated disorders, 2013-10, Vol.27 (4), p.310-315 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult and adolescent clinical studies Aged Alzheimer Disease - diagnosis Alzheimer Disease - psychology Biological and medical sciences Brief Psychiatric Rating Scale Cohort Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Female Follow-Up Studies Frontotemporal Lobar Degeneration - diagnosis Frontotemporal Lobar Degeneration - psychology Humans Investigative techniques, diagnostic techniques (general aspects) Longitudinal Studies Male Medical sciences Middle Aged Nervous system Neurology Neuropsychological Tests Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiodiagnosis. Nmr imagery. Nmr spectrometry Single-Blind Method |
| title | Differential Longitudinal Decline on the Mini-Mental State Examination in Frontotemporal Lobar Degeneration and Alzheimer Disease |
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