Ectonucleotidase NTPDase3 is abundant in pancreatic β-cells and regulates glucose-induced insulin secretion

Extracellular ATP released from pancreatic β-cells acts as a potent insulinotropic agent through activation of P2 purinergic receptors. Ectonucleotidases, a family of membrane-bound nucleotide-metabolizing enzymes, regulate extracellular ATP levels by degrading ATP and related nucleotides. Ectonucle...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2013-11, Vol.305 (10), p.E1319-E1326
Hauptverfasser:	Syed, Samreen K, Kauffman, Audra L, Beavers, Lisa S, Alston, James T, Farb, Thomas B, Ficorilli, James, Marcelo, Marialuisa C, Brenner, Martin B, Bokvist, Krister, Barrett, David G, Efanov, Alexander M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Animals Cells, Cultured Enzyme Inhibitors - pharmacology Glucose - metabolism Glucose - pharmacology Humans Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - chemistry Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - enzymology Male Mice Mice, Inbred C57BL Pyrophosphatases - analysis Pyrophosphatases - antagonists & inhibitors Pyrophosphatases - metabolism RNA, Messenger - analysis RNA, Messenger - metabolism Tissue Distribution
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