Biotransformation of 17α-ethynyl substituted steroidal drugs with microbial and plant cell cultures: A review

•Metabolism of 17α-ethynyl steroidal drugs with microbial and plant cell cultures.•Novel biotransformed products in presence of 17α-ethynyl moiety.•Biotransformation resulted regio-selective and stereospecific products.•Experimental and structure elucidation techniques used in biotransformation. Str...

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Veröffentlicht in:	Steroids 2013-12, Vol.78 (14), p.1312-1324
Hauptverfasser:	Shah, Syed Adnan Ali, Sultan, Sadia, Hassan, Normahanim Binti, Muhammad, Fauzia Khadija Binti, Faridz, Muhammad Afifi Bin Mohd, Hussain, Fatimah BeBe M., Hussain, Munawar, Adnan, Humera Syed
Format:	Artikel
Sprache:	eng
Schlagworte:	17α-Ethynyl substituted steroidal drugs Bacteria - metabolism Biotransformation Cell Culture Techniques Cell suspension cultures Drug Discovery Estrenes - chemistry Estrenes - isolation & purification Estrenes - metabolism Ethinyl Estradiol - chemistry Ethinyl Estradiol - isolation & purification Ethinyl Estradiol - metabolism Fungi - metabolism Humans Microbial strains Microbial transformation Norpregnenes - chemistry Norpregnenes - isolation & purification Norpregnenes - metabolism Plant Cells - metabolism Pregnenes - chemistry Pregnenes - isolation & purification Pregnenes - metabolism Stereoisomerism
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