Identification of the cell targets important for propolis-induced cell death in Candida albicans

•Propolis is a mixture of resinous substances which are collected from plants by bees.•We showed the antifungal activity of propolis against all C. albicans morphotypes.•Propolis is able to control C. albicans infections in a mouse model of vulvovaginal candidiasis.•Our results indicate that propoli...

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Veröffentlicht in:	Fungal genetics and biology 2013-11, Vol.60, p.74-86
Hauptverfasser:	de Castro, Patrícia Alves, Bom, Vinícius Leite Pedro, Brown, Neil Andrew, Almeida, Ricardo Sérgio Couto de, Ramalho, Leandra Naira Zambelli, Savoldi, Marcela, Goldman, Maria Helena S., Berretta, Andresa A., Goldman, Gustavo Henrique
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Anti-Infective Agents - pharmacology Antifungal Agents - pharmacology antifungal properties Apoidea biofilm Candida albicans Candida albicans - drug effects Candida albicans - genetics candidiasis Candidiasis, Vulvovaginal - drug therapy Candidiasis, Vulvovaginal - microbiology Caspases - metabolism cell adhesion cell death Deletion mutants Female fungi genes homozygosity hyphae Mice Mice, Inbred BALB C mortality mutants pathogenesis pathogens Propolis Propolis - pharmacology Proto-Oncogene Proteins p21(ras) - metabolism Vulvovaginal candidiasis
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