Multidisciplinary therapy including proton beam radiotherapy for a Ewing sarcoma family tumor of maxillary sinus in a 4‐year‐old girl
Background Although complete resection offers the best chance for controlling head and neck Ewing sarcoma family tumors (ESFTs), it is occasionally unfeasible because of possible functional and cosmetic side effects. Planning multidisciplinary treatment for head and neck ESFT is challenging. Methods...
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| Veröffentlicht in: | Head & neck 2013-12, Vol.35 (12), p.E386-E390 |
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| creator | Yamaoka, Masayoshi Akiyama, Masaharu Yokokawa, Yuichi Terao, Yoko Yokoi, Kentaro Kato, Takakuni Fukushima, Takashi Sakurai, Hideyuki Ida, Hiroyuki Andersen, Peter |
| description | Background
Although complete resection offers the best chance for controlling head and neck Ewing sarcoma family tumors (ESFTs), it is occasionally unfeasible because of possible functional and cosmetic side effects. Planning multidisciplinary treatment for head and neck ESFT is challenging.
Methods and Results
A 4‐year‐old girl had left‐sided excessive tearing, nasal obstruction, and exophthalmos for 4 months. A CT scan showed a mass filling the left maxillary sinus and extending to the left orbital wall. After a diagnosis of ESFT was established with biopsy, the patient was treated with vincristine, doxorubicin, cyclophosphamide/ifosfamide etoposide (VDC/IE) regimen over 50 weeks; partial maxillectomy was performed at week 15 and was followed by proton radiotherapy. The patient has remained tumor‐free for 16 months, with preservation of facial form and function.
Conclusion
Partial resection combined with proton radiotherapy may enable maximal tumor control and minimal functional and cosmetic side effects in children with head and neck ESFT. © 2013 Wiley Periodicals, Inc. Head Neck 35: E386–E390, 2013 |
| doi_str_mv | 10.1002/hed.23352 |
| format | Article |
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Although complete resection offers the best chance for controlling head and neck Ewing sarcoma family tumors (ESFTs), it is occasionally unfeasible because of possible functional and cosmetic side effects. Planning multidisciplinary treatment for head and neck ESFT is challenging.
Methods and Results
A 4‐year‐old girl had left‐sided excessive tearing, nasal obstruction, and exophthalmos for 4 months. A CT scan showed a mass filling the left maxillary sinus and extending to the left orbital wall. After a diagnosis of ESFT was established with biopsy, the patient was treated with vincristine, doxorubicin, cyclophosphamide/ifosfamide etoposide (VDC/IE) regimen over 50 weeks; partial maxillectomy was performed at week 15 and was followed by proton radiotherapy. The patient has remained tumor‐free for 16 months, with preservation of facial form and function.
Conclusion
Partial resection combined with proton radiotherapy may enable maximal tumor control and minimal functional and cosmetic side effects in children with head and neck ESFT. © 2013 Wiley Periodicals, Inc. Head Neck 35: E386–E390, 2013</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.23352</identifier><identifier>PMID: 23606421</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Child, Preschool ; Combined Modality Therapy ; Cyclophosphamide - administration & dosage ; dismasking flap approach ; Doxorubicin - administration & dosage ; Etoposide - administration & dosage ; Ewing sarcoma family tumor ; Female ; Humans ; Ifosfamide - administration & dosage ; Maxilla - surgery ; Maxillary Sinus Neoplasms - therapy ; maxillary sinus tumor ; multidisciplinary therapy ; proton beam radiotherapy ; Proton Therapy ; Sarcoma, Ewing - therapy ; Vincristine - administration & dosage</subject><ispartof>Head & neck, 2013-12, Vol.35 (12), p.E386-E390</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4192-cd658b9fb101410a73224c69c3e3937d6d0b9ae5a6fc834fe69ecfe9568cd84b3</citedby><cites>FETCH-LOGICAL-c4192-cd658b9fb101410a73224c69c3e3937d6d0b9ae5a6fc834fe69ecfe9568cd84b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.23352$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.23352$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23606421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamaoka, Masayoshi</creatorcontrib><creatorcontrib>Akiyama, Masaharu</creatorcontrib><creatorcontrib>Yokokawa, Yuichi</creatorcontrib><creatorcontrib>Terao, Yoko</creatorcontrib><creatorcontrib>Yokoi, Kentaro</creatorcontrib><creatorcontrib>Kato, Takakuni</creatorcontrib><creatorcontrib>Fukushima, Takashi</creatorcontrib><creatorcontrib>Sakurai, Hideyuki</creatorcontrib><creatorcontrib>Ida, Hiroyuki</creatorcontrib><creatorcontrib>Andersen, Peter</creatorcontrib><title>Multidisciplinary therapy including proton beam radiotherapy for a Ewing sarcoma family tumor of maxillary sinus in a 4‐year‐old girl</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Although complete resection offers the best chance for controlling head and neck Ewing sarcoma family tumors (ESFTs), it is occasionally unfeasible because of possible functional and cosmetic side effects. Planning multidisciplinary treatment for head and neck ESFT is challenging.
Methods and Results
A 4‐year‐old girl had left‐sided excessive tearing, nasal obstruction, and exophthalmos for 4 months. A CT scan showed a mass filling the left maxillary sinus and extending to the left orbital wall. After a diagnosis of ESFT was established with biopsy, the patient was treated with vincristine, doxorubicin, cyclophosphamide/ifosfamide etoposide (VDC/IE) regimen over 50 weeks; partial maxillectomy was performed at week 15 and was followed by proton radiotherapy. The patient has remained tumor‐free for 16 months, with preservation of facial form and function.
Conclusion
Partial resection combined with proton radiotherapy may enable maximal tumor control and minimal functional and cosmetic side effects in children with head and neck ESFT. © 2013 Wiley Periodicals, Inc. Head Neck 35: E386–E390, 2013</description><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Child, Preschool</subject><subject>Combined Modality Therapy</subject><subject>Cyclophosphamide - administration & dosage</subject><subject>dismasking flap approach</subject><subject>Doxorubicin - administration & dosage</subject><subject>Etoposide - administration & dosage</subject><subject>Ewing sarcoma family tumor</subject><subject>Female</subject><subject>Humans</subject><subject>Ifosfamide - administration & dosage</subject><subject>Maxilla - surgery</subject><subject>Maxillary Sinus Neoplasms - therapy</subject><subject>maxillary sinus tumor</subject><subject>multidisciplinary therapy</subject><subject>proton beam radiotherapy</subject><subject>Proton Therapy</subject><subject>Sarcoma, Ewing - therapy</subject><subject>Vincristine - administration & dosage</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kbtOwzAUhi0EoqUw8ALIEgsMATt2biOCQpFALDBHji9g5MTFbgTdWNl4Rp6EE0oXJKZzZH_-dI5_hPYpOaGEpKdPWp2kjGXpBhpTUhUJYbzYHHrOEkYKPkI7MT4TQljO0200SllOoKNj9HHbu4VVNko7d7YTYYkXTzqI-RLbTrpe2e4Rz4Nf-A43WrQ4CGX9GjE-YIGnrwMURZC-FdiI1jqw9C1ceoNb8WadG8TRdn0ELTzhX--fSy0CFO8UfrTB7aItI1zUe791gh4up_fns-Tm7ur6_OwmkZxWaSJVnpVNZRpKKKdEFCxNucwryTSrWKFyRZpK6EzkRpaMG51XWhpdZXkpVckbNkFHKy9s9dLruKhb2F7DiJ32fawpzwCGv8oAPfyDPvs-dDDdQJWMUVIM1PGKksHHGLSp58G2sHBNST3kU0M-9U8-wB78GvumhdM1uQ4EgNMV8GqdXv5vqmfTi5XyG60vnSc</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Yamaoka, Masayoshi</creator><creator>Akiyama, Masaharu</creator><creator>Yokokawa, Yuichi</creator><creator>Terao, Yoko</creator><creator>Yokoi, Kentaro</creator><creator>Kato, Takakuni</creator><creator>Fukushima, Takashi</creator><creator>Sakurai, Hideyuki</creator><creator>Ida, Hiroyuki</creator><creator>Andersen, Peter</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201312</creationdate><title>Multidisciplinary therapy including proton beam radiotherapy for a Ewing sarcoma family tumor of maxillary sinus in a 4‐year‐old girl</title><author>Yamaoka, Masayoshi ; Akiyama, Masaharu ; Yokokawa, Yuichi ; Terao, Yoko ; Yokoi, Kentaro ; Kato, Takakuni ; Fukushima, Takashi ; Sakurai, Hideyuki ; Ida, Hiroyuki ; Andersen, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4192-cd658b9fb101410a73224c69c3e3937d6d0b9ae5a6fc834fe69ecfe9568cd84b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Child, Preschool</topic><topic>Combined Modality Therapy</topic><topic>Cyclophosphamide - administration & dosage</topic><topic>dismasking flap approach</topic><topic>Doxorubicin - administration & dosage</topic><topic>Etoposide - administration & dosage</topic><topic>Ewing sarcoma family tumor</topic><topic>Female</topic><topic>Humans</topic><topic>Ifosfamide - administration & dosage</topic><topic>Maxilla - surgery</topic><topic>Maxillary Sinus Neoplasms - therapy</topic><topic>maxillary sinus tumor</topic><topic>multidisciplinary therapy</topic><topic>proton beam radiotherapy</topic><topic>Proton Therapy</topic><topic>Sarcoma, Ewing - therapy</topic><topic>Vincristine - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamaoka, Masayoshi</creatorcontrib><creatorcontrib>Akiyama, Masaharu</creatorcontrib><creatorcontrib>Yokokawa, Yuichi</creatorcontrib><creatorcontrib>Terao, Yoko</creatorcontrib><creatorcontrib>Yokoi, Kentaro</creatorcontrib><creatorcontrib>Kato, Takakuni</creatorcontrib><creatorcontrib>Fukushima, Takashi</creatorcontrib><creatorcontrib>Sakurai, Hideyuki</creatorcontrib><creatorcontrib>Ida, Hiroyuki</creatorcontrib><creatorcontrib>Andersen, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamaoka, Masayoshi</au><au>Akiyama, Masaharu</au><au>Yokokawa, Yuichi</au><au>Terao, Yoko</au><au>Yokoi, Kentaro</au><au>Kato, Takakuni</au><au>Fukushima, Takashi</au><au>Sakurai, Hideyuki</au><au>Ida, Hiroyuki</au><au>Andersen, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multidisciplinary therapy including proton beam radiotherapy for a Ewing sarcoma family tumor of maxillary sinus in a 4‐year‐old girl</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2013-12</date><risdate>2013</risdate><volume>35</volume><issue>12</issue><spage>E386</spage><epage>E390</epage><pages>E386-E390</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>Background
Although complete resection offers the best chance for controlling head and neck Ewing sarcoma family tumors (ESFTs), it is occasionally unfeasible because of possible functional and cosmetic side effects. Planning multidisciplinary treatment for head and neck ESFT is challenging.
Methods and Results
A 4‐year‐old girl had left‐sided excessive tearing, nasal obstruction, and exophthalmos for 4 months. A CT scan showed a mass filling the left maxillary sinus and extending to the left orbital wall. After a diagnosis of ESFT was established with biopsy, the patient was treated with vincristine, doxorubicin, cyclophosphamide/ifosfamide etoposide (VDC/IE) regimen over 50 weeks; partial maxillectomy was performed at week 15 and was followed by proton radiotherapy. The patient has remained tumor‐free for 16 months, with preservation of facial form and function.
Conclusion
Partial resection combined with proton radiotherapy may enable maximal tumor control and minimal functional and cosmetic side effects in children with head and neck ESFT. © 2013 Wiley Periodicals, Inc. Head Neck 35: E386–E390, 2013</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>23606421</pmid><doi>10.1002/hed.23352</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use Child, Preschool Combined Modality Therapy Cyclophosphamide - administration & dosage dismasking flap approach Doxorubicin - administration & dosage Etoposide - administration & dosage Ewing sarcoma family tumor Female Humans Ifosfamide - administration & dosage Maxilla - surgery Maxillary Sinus Neoplasms - therapy maxillary sinus tumor multidisciplinary therapy proton beam radiotherapy Proton Therapy Sarcoma, Ewing - therapy Vincristine - administration & dosage |
| title | Multidisciplinary therapy including proton beam radiotherapy for a Ewing sarcoma family tumor of maxillary sinus in a 4‐year‐old girl |
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