PEG as a spacer arm markedly increases the immunogenicity of meningococcal group Y polysaccharide conjugate vaccine

Neisseria meningitidis is a life-threatening pathogen that causes meningitis and other clinical manifestations. As a key virulence determinant, meningococcal capsular polysaccharide (PS) can be used to prevent meningococcal diseases. Conjugation of PS to carrier protein can significantly improve the...

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Veröffentlicht in:	Journal of controlled release 2013-11, Vol.172 (1), p.382-389
Hauptverfasser:	Huang, Qingrui, Li, Dongxia, Kang, Aijun, An, Wenqi, Fan, Bei, Ma, Xiaowei, Ma, Guanghui, Su, Zhiguo, Hu, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Affinity cell-mediated immunity children Conjugate vaccine epitopes Female Humans hydrophilicity immune response Immunization Immunogenicity immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology infants memory meningitis Meningitis, Meningococcal - immunology Meningitis, Meningococcal - microbiology Meningitis, Meningococcal - prevention & control Mice Mice, Inbred BALB C Neisseria meningitidis Neisseria meningitidis - immunology pathogens Polyethylene glycol Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry Polyethylene Glycols - metabolism Polysaccharides, Bacterial - administration & dosage Polysaccharides, Bacterial - chemistry Polysaccharides, Bacterial - immunology Spacer arm tetanus vaccines Vaccines, Conjugate - administration & dosage Vaccines, Conjugate - chemistry Vaccines, Conjugate - immunology virulence
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