Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer
Vascular endothelial growth factor (VEGF) gene is an important angiogenesis regulator related to cancer development and progression. We evaluated the association between -2578 C/A (rs699947) VEGF polymorphism and PCa in Mexican subjects, to contribute to knowledge of VEGF role in genetic epidemiolog...
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| Veröffentlicht in: | Cancer biomarkers : section A of Disease markers 2013-01, Vol.13 (4), p.235-241 |
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| creator | Martinez-Fierro, M L Garza-Veloz, I Rojas-Martinez, A Ortiz-Lopez, R Castruita-de la Rosa, C Ortiz-Castro, Y Lazalde-Ramos, B P Cervantes-Villagrana, A R Castañeda-Lopez, M E Gomez-Guerra, L Delgado-Enciso, I Martinez-Torres, A A |
| description | Vascular endothelial growth factor (VEGF) gene is an important angiogenesis regulator related to cancer development and progression. We evaluated the association between -2578 C/A (rs699947) VEGF polymorphism and PCa in Mexican subjects, to contribute to knowledge of VEGF role in genetic epidemiology of prostate cancer (PCa).
The aim of this study was to evaluate the association between -2578 C/A VEGF variant and PCa in Mexican population.
A total of 249 men (77 PCa cases and 172 controls) from the Northwestern region of Mexico were screened for the -2578 C/A VEGF variant. The polymorphism was determined by polymerase chain reaction-based restriction analysis.
Genotype frequencies for C/C, C/A, and A/A, were 0.48, 0.49, 0.03 for cases and 0.41, 0.45, 0.14 for controls respectively. Genotype A/A of -2578 VEGF variant reduces the risk of PCa in an 84% among studied population (Odds Ratio 0.16; 95% CI: 0.04-0.71, P=0.007). C/C carriers showed an increased PCa risk of 6.1 times among the study population.
Inheritance of -2578 A/A genotype of VEGF gene may modify PCa susceptibility risk in Mexican population. |
| doi_str_mv | 10.3233/CBM-130348 |
| format | Article |
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The aim of this study was to evaluate the association between -2578 C/A VEGF variant and PCa in Mexican population.
A total of 249 men (77 PCa cases and 172 controls) from the Northwestern region of Mexico were screened for the -2578 C/A VEGF variant. The polymorphism was determined by polymerase chain reaction-based restriction analysis.
Genotype frequencies for C/C, C/A, and A/A, were 0.48, 0.49, 0.03 for cases and 0.41, 0.45, 0.14 for controls respectively. Genotype A/A of -2578 VEGF variant reduces the risk of PCa in an 84% among studied population (Odds Ratio 0.16; 95% CI: 0.04-0.71, P=0.007). C/C carriers showed an increased PCa risk of 6.1 times among the study population.
Inheritance of -2578 A/A genotype of VEGF gene may modify PCa susceptibility risk in Mexican population.</description><identifier>ISSN: 1574-0153</identifier><identifier>EISSN: 1875-8592</identifier><identifier>DOI: 10.3233/CBM-130348</identifier><identifier>PMID: 24240584</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Alleles ; Case-Control Studies ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Inheritance Patterns ; Male ; Mexico ; Middle Aged ; Neoplasm Grading ; Odds Ratio ; Polymorphism, Single Nucleotide ; Prostate-Specific Antigen - blood ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - pathology ; Retrospective Studies ; Vascular Endothelial Growth Factor A - genetics</subject><ispartof>Cancer biomarkers : section A of Disease markers, 2013-01, Vol.13 (4), p.235-241</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-1bae16687d1ee120d71851a72cac11ae1911315f76104e1336437a915ce31bc83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27913,27914</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24240584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martinez-Fierro, M L</creatorcontrib><creatorcontrib>Garza-Veloz, I</creatorcontrib><creatorcontrib>Rojas-Martinez, A</creatorcontrib><creatorcontrib>Ortiz-Lopez, R</creatorcontrib><creatorcontrib>Castruita-de la Rosa, C</creatorcontrib><creatorcontrib>Ortiz-Castro, Y</creatorcontrib><creatorcontrib>Lazalde-Ramos, B P</creatorcontrib><creatorcontrib>Cervantes-Villagrana, A R</creatorcontrib><creatorcontrib>Castañeda-Lopez, M E</creatorcontrib><creatorcontrib>Gomez-Guerra, L</creatorcontrib><creatorcontrib>Delgado-Enciso, I</creatorcontrib><creatorcontrib>Martinez-Torres, A A</creatorcontrib><title>Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer</title><title>Cancer biomarkers : section A of Disease markers</title><addtitle>Cancer Biomark</addtitle><description>Vascular endothelial growth factor (VEGF) gene is an important angiogenesis regulator related to cancer development and progression. We evaluated the association between -2578 C/A (rs699947) VEGF polymorphism and PCa in Mexican subjects, to contribute to knowledge of VEGF role in genetic epidemiology of prostate cancer (PCa).
The aim of this study was to evaluate the association between -2578 C/A VEGF variant and PCa in Mexican population.
A total of 249 men (77 PCa cases and 172 controls) from the Northwestern region of Mexico were screened for the -2578 C/A VEGF variant. The polymorphism was determined by polymerase chain reaction-based restriction analysis.
Genotype frequencies for C/C, C/A, and A/A, were 0.48, 0.49, 0.03 for cases and 0.41, 0.45, 0.14 for controls respectively. Genotype A/A of -2578 VEGF variant reduces the risk of PCa in an 84% among studied population (Odds Ratio 0.16; 95% CI: 0.04-0.71, P=0.007). C/C carriers showed an increased PCa risk of 6.1 times among the study population.
Inheritance of -2578 A/A genotype of VEGF gene may modify PCa susceptibility risk in Mexican population.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Case-Control Studies</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Inheritance Patterns</subject><subject>Male</subject><subject>Mexico</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Odds Ratio</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Retrospective Studies</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><issn>1574-0153</issn><issn>1875-8592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFPAjEQhRujEUQv_gDTI5qsdLYt2z0qATTB6EG9bobuIGuWXWwLxH9vDehpJpk3b-Z9jF2CuJWplIPR_VMCUkhljlgXTKYTo_P0OPY6U4kALTvszPtPIZSEND9lnVSlSmijuqx-aX0Vqi1x9L61FYaqbficwo6o4Vv0dlOj49SUbVhSXWHNP1y7C0u-QBtax_vv4-nkmiepzgwfDe7ijquwCRybkq9d6wMG4hYbS-6cnSyw9nRxqD32Nhm_jh6S2fP0cXQ3S2zMExKYI8FwaLISiCAVZQZGA2apRQsQZzmABL3IhiAUgZRDJTPMQVuSMLdG9lh_7xvvf23Ih2JVeUt1jQ21G1-A0rmO8Y2K0pu91MZXvaNFsXbVCt13AaL4pVtEusWebhRfHXw38xWV_9I_nPIHltZy8w</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Martinez-Fierro, M L</creator><creator>Garza-Veloz, I</creator><creator>Rojas-Martinez, A</creator><creator>Ortiz-Lopez, R</creator><creator>Castruita-de la Rosa, C</creator><creator>Ortiz-Castro, Y</creator><creator>Lazalde-Ramos, B P</creator><creator>Cervantes-Villagrana, A R</creator><creator>Castañeda-Lopez, M E</creator><creator>Gomez-Guerra, L</creator><creator>Delgado-Enciso, I</creator><creator>Martinez-Torres, A A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer</title><author>Martinez-Fierro, M L ; Garza-Veloz, I ; Rojas-Martinez, A ; Ortiz-Lopez, R ; Castruita-de la Rosa, C ; Ortiz-Castro, Y ; Lazalde-Ramos, B P ; Cervantes-Villagrana, A R ; Castañeda-Lopez, M E ; Gomez-Guerra, L ; Delgado-Enciso, I ; Martinez-Torres, A A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-1bae16687d1ee120d71851a72cac11ae1911315f76104e1336437a915ce31bc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Case-Control Studies</topic><topic>Gene Frequency</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Inheritance Patterns</topic><topic>Male</topic><topic>Mexico</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Odds Ratio</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Retrospective Studies</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martinez-Fierro, M L</creatorcontrib><creatorcontrib>Garza-Veloz, I</creatorcontrib><creatorcontrib>Rojas-Martinez, A</creatorcontrib><creatorcontrib>Ortiz-Lopez, R</creatorcontrib><creatorcontrib>Castruita-de la Rosa, C</creatorcontrib><creatorcontrib>Ortiz-Castro, Y</creatorcontrib><creatorcontrib>Lazalde-Ramos, B P</creatorcontrib><creatorcontrib>Cervantes-Villagrana, A R</creatorcontrib><creatorcontrib>Castañeda-Lopez, M E</creatorcontrib><creatorcontrib>Gomez-Guerra, L</creatorcontrib><creatorcontrib>Delgado-Enciso, I</creatorcontrib><creatorcontrib>Martinez-Torres, A A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer biomarkers : section A of Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martinez-Fierro, M L</au><au>Garza-Veloz, I</au><au>Rojas-Martinez, A</au><au>Ortiz-Lopez, R</au><au>Castruita-de la Rosa, C</au><au>Ortiz-Castro, Y</au><au>Lazalde-Ramos, B P</au><au>Cervantes-Villagrana, A R</au><au>Castañeda-Lopez, M E</au><au>Gomez-Guerra, L</au><au>Delgado-Enciso, I</au><au>Martinez-Torres, A A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer</atitle><jtitle>Cancer biomarkers : section A of Disease markers</jtitle><addtitle>Cancer Biomark</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>13</volume><issue>4</issue><spage>235</spage><epage>241</epage><pages>235-241</pages><issn>1574-0153</issn><eissn>1875-8592</eissn><abstract>Vascular endothelial growth factor (VEGF) gene is an important angiogenesis regulator related to cancer development and progression. We evaluated the association between -2578 C/A (rs699947) VEGF polymorphism and PCa in Mexican subjects, to contribute to knowledge of VEGF role in genetic epidemiology of prostate cancer (PCa).
The aim of this study was to evaluate the association between -2578 C/A VEGF variant and PCa in Mexican population.
A total of 249 men (77 PCa cases and 172 controls) from the Northwestern region of Mexico were screened for the -2578 C/A VEGF variant. The polymorphism was determined by polymerase chain reaction-based restriction analysis.
Genotype frequencies for C/C, C/A, and A/A, were 0.48, 0.49, 0.03 for cases and 0.41, 0.45, 0.14 for controls respectively. Genotype A/A of -2578 VEGF variant reduces the risk of PCa in an 84% among studied population (Odds Ratio 0.16; 95% CI: 0.04-0.71, P=0.007). C/C carriers showed an increased PCa risk of 6.1 times among the study population.
Inheritance of -2578 A/A genotype of VEGF gene may modify PCa susceptibility risk in Mexican population.</abstract><cop>Netherlands</cop><pmid>24240584</pmid><doi>10.3233/CBM-130348</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Sage Journals GOLD Open Access 2024 |
| subjects | Age Factors Aged Aged, 80 and over Alleles Case-Control Studies Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Inheritance Patterns Male Mexico Middle Aged Neoplasm Grading Odds Ratio Polymorphism, Single Nucleotide Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Retrospective Studies Vascular Endothelial Growth Factor A - genetics |
| title | Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer |
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