A coumarin-based fluorescent probe for biological thiols and its application for living cell imaging

In this work, compound 1 has been rationally designed and synthesized as a new fluorescent probe for biological thiols. Notably, probe 1 has almost no background fluorescence (Φf < 0.0001) in aqueous solutions; however, it exhibited fluorescence turn-on response to thiols with high sensitivity (a...

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Veröffentlicht in:	Organic & biomolecular chemistry 2013-12, Vol.11 (47), p.8214-8220
Hauptverfasser:	Long, Lingliang, Zhou, Liping, Wang, Lin, Meng, Suci, Gong, Aihua, Du, Fengyi, Zhang, Chi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Survival Coumarins - chemistry Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Humans Hydrogen-Ion Concentration Kinetics Models, Molecular Molecular Structure Pancreatic Neoplasms - chemistry Pancreatic Neoplasms - pathology Quantum Theory Sulfhydryl Compounds - blood
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