Downregulation of p21 in myelodysplastic syndrome is associated with p73 promoter hypermethylation and indicates poor prognosis

p21 Can both promote and inhibit tumorigenic processes. We explored the role of p21 in myelodysplastic syndrome (MDS). In this study, we analyzed p21 expression and p73 methylation in 88 patients with de novo MDS. We found decreased expression of the p21 gene in higher-risk MDS compared with lower-r...

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