Copper-Catalyzed Oxidative Ring Closure and Carboarylation of 2‑Ethynylanilides

A new copper-catalyzed oxidative ring closure of ethynyl anilides with diaryliodonium salts was developed for the highly modular construction of benzoxazines bearing a fully substituted exo double bond. The oxidative transformation includes an unusual 6-exo-dig cyclization step with the formation of...

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Veröffentlicht in:	Organic letters 2013-11, Vol.15 (22), p.5654-5657
Hauptverfasser:	Sinai, Ádám, Mészáros, Ádám, Gáti, Tamás, Kudar, Veronika, Palló, Anna, Novák, Zoltán
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilides - chemistry Benzoxazines - chemical synthesis Benzoxazines - chemistry Catalysis Copper - chemistry Cyclization Molecular Structure Onium Compounds - chemistry Oxidation-Reduction
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creator	Sinai, Ádám Mészáros, Ádám Gáti, Tamás Kudar, Veronika Palló, Anna Novák, Zoltán
description	A new copper-catalyzed oxidative ring closure of ethynyl anilides with diaryliodonium salts was developed for the highly modular construction of benzoxazines bearing a fully substituted exo double bond. The oxidative transformation includes an unusual 6-exo-dig cyclization step with the formation of C–O and C–C bonds.
doi_str_mv	10.1021/ol402600r
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subjects	Anilides - chemistry Benzoxazines - chemical synthesis Benzoxazines - chemistry Catalysis Copper - chemistry Cyclization Molecular Structure Onium Compounds - chemistry Oxidation-Reduction
title	Copper-Catalyzed Oxidative Ring Closure and Carboarylation of 2‑Ethynylanilides
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