Eye closure sensitivity in juvenile myoclonic epilepsy and its effect on prognosis
Abstract Purpose To investigate eye closure sensitivity (ECS) in the EEGs of patients diagnosed with juvenile myoclonic epilepsy (JME) and its relationship to prognosis. Methods We included 76 JME patients with a minimum follow-up of one year and evaluated a total of 254 EEGs to obtain evidence of E...
Gespeichert in:
| Veröffentlicht in: | Seizure (London, England) England), 2013-12, Vol.22 (10), p.867-871 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 871 |
|---|---|
| container_issue | 10 |
| container_start_page | 867 |
| container_title | Seizure (London, England) |
| container_volume | 22 |
| creator | Tekin Güveli, Betül Baykan, Betül Dörtcan, Nimet Bebek, Nerses Gürses, Candan Gökyiğit, Ayşen |
| description | Abstract Purpose To investigate eye closure sensitivity (ECS) in the EEGs of patients diagnosed with juvenile myoclonic epilepsy (JME) and its relationship to prognosis. Methods We included 76 JME patients with a minimum follow-up of one year and evaluated a total of 254 EEGs to obtain evidence of ECS. The patients were grouped according to their response to treatment, and these subgroups were compared in relation to ECS and other clinical and EEG features. Results There were 12 patients (15.8%) with poor prognosis who showed resistance to appropriate anti-epileptic drug treatment, 15 (19.7%) patients with pseudo-resistance, and 49 (64.5%) patients with good prognosis. The EEGs of only four of the patients displayed pure ECS (5.3%), and only one of these exhibited poor prognosis. Furthermore, 11 patients (14.5%) had both ECS and photosensitivity, and two of these patients exhibited poor prognosis. Thus, neither pure ECS nor ECS with photosensitivity correlated with poor prognosis. A family history of epilepsy and focal findings on the EEG was correlated with poorer prognosis. Conclusions ECS is a rare EEG finding in JME and does not appear to be a marker for poor prognosis. |
| doi_str_mv | 10.1016/j.seizure.2013.07.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1459160844</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S105913111300201X</els_id><sourcerecordid>1459160844</sourcerecordid><originalsourceid>FETCH-LOGICAL-c467t-b4260df9ab833ae649d620df20a889114a12794f8c24e02fdd7a3b7b460603813</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EoqXwE0A-ckkYf8RJLiBUtbRSJSQ-JG6W40yQQ9ZeMslK4dfj1S4cuHAaj_XO-2qeYeylgFKAMG_GkjD8WmcsJQhVQl0CNI_YpaiULKRpmsf5DVVbCCXEBXtGNAJAq4V6yi6kao2spLxkn2425H5KlJ04YaSwhENYNh4iH9cDxjAh320pS2LwHPe539PGXex5WIjjMKBfeIp8P6fvMVGg5-zJ4CbCF-d6xb7e3ny5visePn64v37_UHht6qXotDTQD63rGqUcGt32RuYPCa5pWiG0E7Ju9dB4qRHk0Pe1U13daQMGVCPUFXt98s3JP1ekxe4CeZwmFzGtZIWuWmGg0TpLq5PUz4loxsHu57Bz82YF2CNOO9ozTnvEaaG2GWeee3WOWLsd9n-n_vDLgncnAeZFDwFnSz5g9NiHOXOxfQr_jXj7j4OfQkbtph-4IY1pnWOmaIUlacF-Pt70eFKhALLPN_UbzVqeWQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1459160844</pqid></control><display><type>article</type><title>Eye closure sensitivity in juvenile myoclonic epilepsy and its effect on prognosis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Tekin Güveli, Betül ; Baykan, Betül ; Dörtcan, Nimet ; Bebek, Nerses ; Gürses, Candan ; Gökyiğit, Ayşen</creator><creatorcontrib>Tekin Güveli, Betül ; Baykan, Betül ; Dörtcan, Nimet ; Bebek, Nerses ; Gürses, Candan ; Gökyiğit, Ayşen</creatorcontrib><description>Abstract Purpose To investigate eye closure sensitivity (ECS) in the EEGs of patients diagnosed with juvenile myoclonic epilepsy (JME) and its relationship to prognosis. Methods We included 76 JME patients with a minimum follow-up of one year and evaluated a total of 254 EEGs to obtain evidence of ECS. The patients were grouped according to their response to treatment, and these subgroups were compared in relation to ECS and other clinical and EEG features. Results There were 12 patients (15.8%) with poor prognosis who showed resistance to appropriate anti-epileptic drug treatment, 15 (19.7%) patients with pseudo-resistance, and 49 (64.5%) patients with good prognosis. The EEGs of only four of the patients displayed pure ECS (5.3%), and only one of these exhibited poor prognosis. Furthermore, 11 patients (14.5%) had both ECS and photosensitivity, and two of these patients exhibited poor prognosis. Thus, neither pure ECS nor ECS with photosensitivity correlated with poor prognosis. A family history of epilepsy and focal findings on the EEG was correlated with poorer prognosis. Conclusions ECS is a rare EEG finding in JME and does not appear to be a marker for poor prognosis.</description><identifier>ISSN: 1059-1311</identifier><identifier>EISSN: 1532-2688</identifier><identifier>DOI: 10.1016/j.seizure.2013.07.008</identifier><identifier>PMID: 23962522</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Anticonvulsants - therapeutic use ; Blinking - physiology ; Brain - physiopathology ; Child ; EEG ; Electroencephalography ; Eye closure sensitivity ; Female ; Humans ; Juvenile myoclonic epilepsy ; Male ; Myoclonic Epilepsy, Juvenile - diagnosis ; Myoclonic Epilepsy, Juvenile - drug therapy ; Myoclonic Epilepsy, Juvenile - physiopathology ; Neurology ; Prognosis ; Theraphy</subject><ispartof>Seizure (London, England), 2013-12, Vol.22 (10), p.867-871</ispartof><rights>British Epilepsy Association</rights><rights>2013 British Epilepsy Association</rights><rights>Copyright © 2013 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-b4260df9ab833ae649d620df20a889114a12794f8c24e02fdd7a3b7b460603813</citedby><cites>FETCH-LOGICAL-c467t-b4260df9ab833ae649d620df20a889114a12794f8c24e02fdd7a3b7b460603813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S105913111300201X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23962522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tekin Güveli, Betül</creatorcontrib><creatorcontrib>Baykan, Betül</creatorcontrib><creatorcontrib>Dörtcan, Nimet</creatorcontrib><creatorcontrib>Bebek, Nerses</creatorcontrib><creatorcontrib>Gürses, Candan</creatorcontrib><creatorcontrib>Gökyiğit, Ayşen</creatorcontrib><title>Eye closure sensitivity in juvenile myoclonic epilepsy and its effect on prognosis</title><title>Seizure (London, England)</title><addtitle>Seizure</addtitle><description>Abstract Purpose To investigate eye closure sensitivity (ECS) in the EEGs of patients diagnosed with juvenile myoclonic epilepsy (JME) and its relationship to prognosis. Methods We included 76 JME patients with a minimum follow-up of one year and evaluated a total of 254 EEGs to obtain evidence of ECS. The patients were grouped according to their response to treatment, and these subgroups were compared in relation to ECS and other clinical and EEG features. Results There were 12 patients (15.8%) with poor prognosis who showed resistance to appropriate anti-epileptic drug treatment, 15 (19.7%) patients with pseudo-resistance, and 49 (64.5%) patients with good prognosis. The EEGs of only four of the patients displayed pure ECS (5.3%), and only one of these exhibited poor prognosis. Furthermore, 11 patients (14.5%) had both ECS and photosensitivity, and two of these patients exhibited poor prognosis. Thus, neither pure ECS nor ECS with photosensitivity correlated with poor prognosis. A family history of epilepsy and focal findings on the EEG was correlated with poorer prognosis. Conclusions ECS is a rare EEG finding in JME and does not appear to be a marker for poor prognosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Blinking - physiology</subject><subject>Brain - physiopathology</subject><subject>Child</subject><subject>EEG</subject><subject>Electroencephalography</subject><subject>Eye closure sensitivity</subject><subject>Female</subject><subject>Humans</subject><subject>Juvenile myoclonic epilepsy</subject><subject>Male</subject><subject>Myoclonic Epilepsy, Juvenile - diagnosis</subject><subject>Myoclonic Epilepsy, Juvenile - drug therapy</subject><subject>Myoclonic Epilepsy, Juvenile - physiopathology</subject><subject>Neurology</subject><subject>Prognosis</subject><subject>Theraphy</subject><issn>1059-1311</issn><issn>1532-2688</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EoqXwE0A-ckkYf8RJLiBUtbRSJSQ-JG6W40yQQ9ZeMslK4dfj1S4cuHAaj_XO-2qeYeylgFKAMG_GkjD8WmcsJQhVQl0CNI_YpaiULKRpmsf5DVVbCCXEBXtGNAJAq4V6yi6kao2spLxkn2425H5KlJ04YaSwhENYNh4iH9cDxjAh320pS2LwHPe539PGXex5WIjjMKBfeIp8P6fvMVGg5-zJ4CbCF-d6xb7e3ny5visePn64v37_UHht6qXotDTQD63rGqUcGt32RuYPCa5pWiG0E7Ju9dB4qRHk0Pe1U13daQMGVCPUFXt98s3JP1ekxe4CeZwmFzGtZIWuWmGg0TpLq5PUz4loxsHu57Bz82YF2CNOO9ozTnvEaaG2GWeee3WOWLsd9n-n_vDLgncnAeZFDwFnSz5g9NiHOXOxfQr_jXj7j4OfQkbtph-4IY1pnWOmaIUlacF-Pt70eFKhALLPN_UbzVqeWQ</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Tekin Güveli, Betül</creator><creator>Baykan, Betül</creator><creator>Dörtcan, Nimet</creator><creator>Bebek, Nerses</creator><creator>Gürses, Candan</creator><creator>Gökyiğit, Ayşen</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131201</creationdate><title>Eye closure sensitivity in juvenile myoclonic epilepsy and its effect on prognosis</title><author>Tekin Güveli, Betül ; Baykan, Betül ; Dörtcan, Nimet ; Bebek, Nerses ; Gürses, Candan ; Gökyiğit, Ayşen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-b4260df9ab833ae649d620df20a889114a12794f8c24e02fdd7a3b7b460603813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Blinking - physiology</topic><topic>Brain - physiopathology</topic><topic>Child</topic><topic>EEG</topic><topic>Electroencephalography</topic><topic>Eye closure sensitivity</topic><topic>Female</topic><topic>Humans</topic><topic>Juvenile myoclonic epilepsy</topic><topic>Male</topic><topic>Myoclonic Epilepsy, Juvenile - diagnosis</topic><topic>Myoclonic Epilepsy, Juvenile - drug therapy</topic><topic>Myoclonic Epilepsy, Juvenile - physiopathology</topic><topic>Neurology</topic><topic>Prognosis</topic><topic>Theraphy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tekin Güveli, Betül</creatorcontrib><creatorcontrib>Baykan, Betül</creatorcontrib><creatorcontrib>Dörtcan, Nimet</creatorcontrib><creatorcontrib>Bebek, Nerses</creatorcontrib><creatorcontrib>Gürses, Candan</creatorcontrib><creatorcontrib>Gökyiğit, Ayşen</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seizure (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tekin Güveli, Betül</au><au>Baykan, Betül</au><au>Dörtcan, Nimet</au><au>Bebek, Nerses</au><au>Gürses, Candan</au><au>Gökyiğit, Ayşen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eye closure sensitivity in juvenile myoclonic epilepsy and its effect on prognosis</atitle><jtitle>Seizure (London, England)</jtitle><addtitle>Seizure</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>22</volume><issue>10</issue><spage>867</spage><epage>871</epage><pages>867-871</pages><issn>1059-1311</issn><eissn>1532-2688</eissn><abstract>Abstract Purpose To investigate eye closure sensitivity (ECS) in the EEGs of patients diagnosed with juvenile myoclonic epilepsy (JME) and its relationship to prognosis. Methods We included 76 JME patients with a minimum follow-up of one year and evaluated a total of 254 EEGs to obtain evidence of ECS. The patients were grouped according to their response to treatment, and these subgroups were compared in relation to ECS and other clinical and EEG features. Results There were 12 patients (15.8%) with poor prognosis who showed resistance to appropriate anti-epileptic drug treatment, 15 (19.7%) patients with pseudo-resistance, and 49 (64.5%) patients with good prognosis. The EEGs of only four of the patients displayed pure ECS (5.3%), and only one of these exhibited poor prognosis. Furthermore, 11 patients (14.5%) had both ECS and photosensitivity, and two of these patients exhibited poor prognosis. Thus, neither pure ECS nor ECS with photosensitivity correlated with poor prognosis. A family history of epilepsy and focal findings on the EEG was correlated with poorer prognosis. Conclusions ECS is a rare EEG finding in JME and does not appear to be a marker for poor prognosis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23962522</pmid><doi>10.1016/j.seizure.2013.07.008</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1059-1311 |
| ispartof | Seizure (London, England), 2013-12, Vol.22 (10), p.867-871 |
| issn | 1059-1311 1532-2688 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1459160844 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Anticonvulsants - therapeutic use Blinking - physiology Brain - physiopathology Child EEG Electroencephalography Eye closure sensitivity Female Humans Juvenile myoclonic epilepsy Male Myoclonic Epilepsy, Juvenile - diagnosis Myoclonic Epilepsy, Juvenile - drug therapy Myoclonic Epilepsy, Juvenile - physiopathology Neurology Prognosis Theraphy |
| title | Eye closure sensitivity in juvenile myoclonic epilepsy and its effect on prognosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T09%3A37%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Eye%20closure%20sensitivity%20in%20juvenile%20myoclonic%20epilepsy%20and%20its%20effect%20on%20prognosis&rft.jtitle=Seizure%20(London,%20England)&rft.au=Tekin%20G%C3%BCveli,%20Bet%C3%BCl&rft.date=2013-12-01&rft.volume=22&rft.issue=10&rft.spage=867&rft.epage=871&rft.pages=867-871&rft.issn=1059-1311&rft.eissn=1532-2688&rft_id=info:doi/10.1016/j.seizure.2013.07.008&rft_dat=%3Cproquest_cross%3E1459160844%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1459160844&rft_id=info:pmid/23962522&rft_els_id=S105913111300201X&rfr_iscdi=true |