Association Between Postoperative Complications and Clinical Cancer Outcomes
Introduction The treatment for a majority of solid organ tumors is surgical resection; 10–20 % of patients suffer a perioperative complication. Perioperative complications may contribute to cancer recurrence. This study examined the relationship between postoperative complications and risk-adjusted...
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| Veröffentlicht in: | Annals of surgical oncology 2013-12, Vol.20 (13), p.4063-4066 |
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| container_title | Annals of surgical oncology |
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| creator | Scaife, Courtney L. Hartz, Arthur Pappas, Lisa Pelletier, Peter He, Tao Glasgow, Robert E. Mulvihill, Sean J. |
| description | Introduction
The treatment for a majority of solid organ tumors is surgical resection; 10–20 % of patients suffer a perioperative complication. Perioperative complications may contribute to cancer recurrence. This study examined the relationship between postoperative complications and risk-adjusted patient overall survival.
Methods
Data from 2003 to 2009 were linked from our clinical cancer registry, the National Surgery Quality Improvement Project (NSQIP), and medical records. Patients who had tumor extirpation for cure were included. The NSQIP was used to identify complications. Patients with a complication were matched to patients without a complication.
χ
2
tests and Cox proportional hazard regression models were used.
Results
A total of 415 patients were included for survival analysis. The hazard ratio (HR) for mortality associated with having a complication was 2.17. The HR for mortality after 200 days postoperatively was 2.47. Infectious complications were associated with the highest association with increased mortality (HR = 3.56). Noninfectious complications were not associated with an increased risk of mortality.
Conclusions
This study investigated the relationship of surgical infectious complications in cancer patients with long-term survival for patients who had a number of different types of cancer. After taking into account the site, histology, and stage of the cancer, we found that patients with infectious complications had earlier death. |
| doi_str_mv | 10.1245/s10434-013-3267-0 |
| format | Article |
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The treatment for a majority of solid organ tumors is surgical resection; 10–20 % of patients suffer a perioperative complication. Perioperative complications may contribute to cancer recurrence. This study examined the relationship between postoperative complications and risk-adjusted patient overall survival.
Methods
Data from 2003 to 2009 were linked from our clinical cancer registry, the National Surgery Quality Improvement Project (NSQIP), and medical records. Patients who had tumor extirpation for cure were included. The NSQIP was used to identify complications. Patients with a complication were matched to patients without a complication.
χ
2
tests and Cox proportional hazard regression models were used.
Results
A total of 415 patients were included for survival analysis. The hazard ratio (HR) for mortality associated with having a complication was 2.17. The HR for mortality after 200 days postoperatively was 2.47. Infectious complications were associated with the highest association with increased mortality (HR = 3.56). Noninfectious complications were not associated with an increased risk of mortality.
Conclusions
This study investigated the relationship of surgical infectious complications in cancer patients with long-term survival for patients who had a number of different types of cancer. After taking into account the site, histology, and stage of the cancer, we found that patients with infectious complications had earlier death.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-013-3267-0</identifier><identifier>PMID: 24052315</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Databases, Factual ; Female ; Follow-Up Studies ; Healthcare Policy and Outcomes ; Humans ; Infection - mortality ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasms - mortality ; Neoplasms - surgery ; Oncology ; Patient Selection ; Postoperative Complications - mortality ; Prognosis ; Surgery ; Surgical Oncology ; Survival Rate ; Young Adult</subject><ispartof>Annals of surgical oncology, 2013-12, Vol.20 (13), p.4063-4066</ispartof><rights>Society of Surgical Oncology 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-b60db6fc761edf90b70b5aa341c1c3273ddea1b1e5d7c0f13f60ddfa5e523ed33</citedby><cites>FETCH-LOGICAL-c438t-b60db6fc761edf90b70b5aa341c1c3273ddea1b1e5d7c0f13f60ddfa5e523ed33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-013-3267-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-013-3267-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24052315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scaife, Courtney L.</creatorcontrib><creatorcontrib>Hartz, Arthur</creatorcontrib><creatorcontrib>Pappas, Lisa</creatorcontrib><creatorcontrib>Pelletier, Peter</creatorcontrib><creatorcontrib>He, Tao</creatorcontrib><creatorcontrib>Glasgow, Robert E.</creatorcontrib><creatorcontrib>Mulvihill, Sean J.</creatorcontrib><title>Association Between Postoperative Complications and Clinical Cancer Outcomes</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Introduction
The treatment for a majority of solid organ tumors is surgical resection; 10–20 % of patients suffer a perioperative complication. Perioperative complications may contribute to cancer recurrence. This study examined the relationship between postoperative complications and risk-adjusted patient overall survival.
Methods
Data from 2003 to 2009 were linked from our clinical cancer registry, the National Surgery Quality Improvement Project (NSQIP), and medical records. Patients who had tumor extirpation for cure were included. The NSQIP was used to identify complications. Patients with a complication were matched to patients without a complication.
χ
2
tests and Cox proportional hazard regression models were used.
Results
A total of 415 patients were included for survival analysis. The hazard ratio (HR) for mortality associated with having a complication was 2.17. The HR for mortality after 200 days postoperatively was 2.47. Infectious complications were associated with the highest association with increased mortality (HR = 3.56). Noninfectious complications were not associated with an increased risk of mortality.
Conclusions
This study investigated the relationship of surgical infectious complications in cancer patients with long-term survival for patients who had a number of different types of cancer. After taking into account the site, histology, and stage of the cancer, we found that patients with infectious complications had earlier death.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Databases, Factual</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Healthcare Policy and Outcomes</subject><subject>Humans</subject><subject>Infection - mortality</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasms - mortality</subject><subject>Neoplasms - surgery</subject><subject>Oncology</subject><subject>Patient Selection</subject><subject>Postoperative Complications - mortality</subject><subject>Prognosis</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Young Adult</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kEtLxDAUhYMoOj5-gBspuHFTzc2j7SzH4gsGdKHrkCa3UmmbMWkV_70ZO4oIru7l5Dsnl0PIMdBzYEJeBKCCi5QCTznL8pRukRnIqIisgO2406xI5yyTe2Q_hBdKIedU7pI9JqhkHOSMLBchONPooXF9conDO2KfPLgwuBX6qL5hUrpu1TbmCwmJ7m1Stk0fhTYpdW_QJ_fjYFyH4ZDs1LoNeLSZB-Tp-uqxvE2X9zd35WKZGsGLIa0yaqusNnkGaOs5rXJaSa25AAOGs5xbixoqQGlzQ2vgdTTYWkuMR6Pl_ICcTbkr715HDIPqmmCwbXWPbgwKhJyDLFhRRPT0D_riRt_H69ZUwei8ABEpmCjjXQgea7XyTaf9hwKq1lWrqWoVq1brqhWNnpNN8lh1aH8c391GgE1AiE_9M_pfX_-b-gmrEImF</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Scaife, Courtney L.</creator><creator>Hartz, Arthur</creator><creator>Pappas, Lisa</creator><creator>Pelletier, Peter</creator><creator>He, Tao</creator><creator>Glasgow, Robert E.</creator><creator>Mulvihill, Sean J.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20131201</creationdate><title>Association Between Postoperative Complications and Clinical Cancer Outcomes</title><author>Scaife, Courtney L. ; Hartz, Arthur ; Pappas, Lisa ; Pelletier, Peter ; He, Tao ; Glasgow, Robert E. ; Mulvihill, Sean J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-b60db6fc761edf90b70b5aa341c1c3273ddea1b1e5d7c0f13f60ddfa5e523ed33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Databases, Factual</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Healthcare Policy and Outcomes</topic><topic>Humans</topic><topic>Infection - mortality</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasms - mortality</topic><topic>Neoplasms - surgery</topic><topic>Oncology</topic><topic>Patient Selection</topic><topic>Postoperative Complications - mortality</topic><topic>Prognosis</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scaife, Courtney L.</creatorcontrib><creatorcontrib>Hartz, Arthur</creatorcontrib><creatorcontrib>Pappas, Lisa</creatorcontrib><creatorcontrib>Pelletier, Peter</creatorcontrib><creatorcontrib>He, Tao</creatorcontrib><creatorcontrib>Glasgow, Robert E.</creatorcontrib><creatorcontrib>Mulvihill, Sean J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scaife, Courtney L.</au><au>Hartz, Arthur</au><au>Pappas, Lisa</au><au>Pelletier, Peter</au><au>He, Tao</au><au>Glasgow, Robert E.</au><au>Mulvihill, Sean J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Postoperative Complications and Clinical Cancer Outcomes</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>20</volume><issue>13</issue><spage>4063</spage><epage>4066</epage><pages>4063-4066</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Introduction
The treatment for a majority of solid organ tumors is surgical resection; 10–20 % of patients suffer a perioperative complication. Perioperative complications may contribute to cancer recurrence. This study examined the relationship between postoperative complications and risk-adjusted patient overall survival.
Methods
Data from 2003 to 2009 were linked from our clinical cancer registry, the National Surgery Quality Improvement Project (NSQIP), and medical records. Patients who had tumor extirpation for cure were included. The NSQIP was used to identify complications. Patients with a complication were matched to patients without a complication.
χ
2
tests and Cox proportional hazard regression models were used.
Results
A total of 415 patients were included for survival analysis. The hazard ratio (HR) for mortality associated with having a complication was 2.17. The HR for mortality after 200 days postoperatively was 2.47. Infectious complications were associated with the highest association with increased mortality (HR = 3.56). Noninfectious complications were not associated with an increased risk of mortality.
Conclusions
This study investigated the relationship of surgical infectious complications in cancer patients with long-term survival for patients who had a number of different types of cancer. After taking into account the site, histology, and stage of the cancer, we found that patients with infectious complications had earlier death.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24052315</pmid><doi>10.1245/s10434-013-3267-0</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2013-12, Vol.20 (13), p.4063-4066 |
| issn | 1068-9265 1534-4681 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Aged, 80 and over Databases, Factual Female Follow-Up Studies Healthcare Policy and Outcomes Humans Infection - mortality Male Medicine Medicine & Public Health Middle Aged Neoplasms - mortality Neoplasms - surgery Oncology Patient Selection Postoperative Complications - mortality Prognosis Surgery Surgical Oncology Survival Rate Young Adult |
| title | Association Between Postoperative Complications and Clinical Cancer Outcomes |
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