Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging
ABSTRACT Background The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS). Methods Fifteen RLS patients and 15 healthy controls were studied using gradient‐echo imaging. Phase analysis was performed on localized b...
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| Veröffentlicht in: | Movement disorders 2013-11, Vol.28 (13), p.1886-1890 |
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| container_start_page | 1886 |
| container_title | Movement disorders |
| container_volume | 28 |
| creator | Rizzo, Giovanni Manners, David Testa, Claudia Tonon, Caterina Vetrugno, Roberto Marconi, Sara Plazzi, Giuseppe Pizza, Fabio Provini, Federica Malucelli, Emil Gramegna, Laura Ludovica Lodi, Raffaele |
| description | ABSTRACT
Background
The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS).
Methods
Fifteen RLS patients and 15 healthy controls were studied using gradient‐echo imaging. Phase analysis was performed on localized brain regions of interest selected on phase maps, sensitive to paramagnetic tissue. Differences between the 2 subject groups were evaluated using ANCOVA including age as a covariate.
Results
Significantly higher phase values were present in the RLS patients compared with healthy controls at the level of the substantia nigra, thalamus, putamen, and pallidum, indicating reduced iron content in several regions of the brain of the patients.
Conclusions
We have used MRI phase analysis to study brain iron content in idiopathic RLS in vivo for the first time. Our results support the hypothesis of reduced brain iron content in RLS patients, which may have an important role in the pathophysiology of the disorder. © 2013 International Parkinson and Movement Disorder Society |
| doi_str_mv | 10.1002/mds.25576 |
| format | Article |
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Background
The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS).
Methods
Fifteen RLS patients and 15 healthy controls were studied using gradient‐echo imaging. Phase analysis was performed on localized brain regions of interest selected on phase maps, sensitive to paramagnetic tissue. Differences between the 2 subject groups were evaluated using ANCOVA including age as a covariate.
Results
Significantly higher phase values were present in the RLS patients compared with healthy controls at the level of the substantia nigra, thalamus, putamen, and pallidum, indicating reduced iron content in several regions of the brain of the patients.
Conclusions
We have used MRI phase analysis to study brain iron content in idiopathic RLS in vivo for the first time. Our results support the hypothesis of reduced brain iron content in RLS patients, which may have an important role in the pathophysiology of the disorder. © 2013 International Parkinson and Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.25576</identifier><identifier>PMID: 23780623</identifier><identifier>CODEN: MOVDEA</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Aged ; Brain - metabolism ; Female ; Humans ; iron ; Iron - metabolism ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Movement disorders ; MRI ; phase imaging ; Restless Legs Syndrome - pathology ; RLS ; Statistics, Nonparametric</subject><ispartof>Movement disorders, 2013-11, Vol.28 (13), p.1886-1890</ispartof><rights>2013 Movement Disorder Society</rights><rights>2013 International Parkinson and Movement Disorder Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4836-dd0daa1064a98da7ea03bbf7c9da0404f3c8ec32a4a8aa003684a2c72413833</citedby><cites>FETCH-LOGICAL-c4836-dd0daa1064a98da7ea03bbf7c9da0404f3c8ec32a4a8aa003684a2c72413833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.25576$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.25576$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23780623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rizzo, Giovanni</creatorcontrib><creatorcontrib>Manners, David</creatorcontrib><creatorcontrib>Testa, Claudia</creatorcontrib><creatorcontrib>Tonon, Caterina</creatorcontrib><creatorcontrib>Vetrugno, Roberto</creatorcontrib><creatorcontrib>Marconi, Sara</creatorcontrib><creatorcontrib>Plazzi, Giuseppe</creatorcontrib><creatorcontrib>Pizza, Fabio</creatorcontrib><creatorcontrib>Provini, Federica</creatorcontrib><creatorcontrib>Malucelli, Emil</creatorcontrib><creatorcontrib>Gramegna, Laura Ludovica</creatorcontrib><creatorcontrib>Lodi, Raffaele</creatorcontrib><title>Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging</title><title>Movement disorders</title><addtitle>Mov Disord</addtitle><description>ABSTRACT
Background
The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS).
Methods
Fifteen RLS patients and 15 healthy controls were studied using gradient‐echo imaging. Phase analysis was performed on localized brain regions of interest selected on phase maps, sensitive to paramagnetic tissue. Differences between the 2 subject groups were evaluated using ANCOVA including age as a covariate.
Results
Significantly higher phase values were present in the RLS patients compared with healthy controls at the level of the substantia nigra, thalamus, putamen, and pallidum, indicating reduced iron content in several regions of the brain of the patients.
Conclusions
We have used MRI phase analysis to study brain iron content in idiopathic RLS in vivo for the first time. Our results support the hypothesis of reduced brain iron content in RLS patients, which may have an important role in the pathophysiology of the disorder. © 2013 International Parkinson and Movement Disorder Society</description><subject>Aged</subject><subject>Brain - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>iron</subject><subject>Iron - metabolism</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>MRI</subject><subject>phase imaging</subject><subject>Restless Legs Syndrome - pathology</subject><subject>RLS</subject><subject>Statistics, Nonparametric</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M1O3DAUBWALtYIpsOgLVJa6oYuAf-LEWVaUTlGHdgESEgusG_vOYJrEUzsjOm9fDwMskFhZlr97dH0I-cjZMWdMnPQuHQul6mqHTLiSvNBC1e_IhGmtCsm12iMfUrpnjHPFq12yJ2StWSXkhNzOwgNtI_iB-hgGasMw4jDSzd35sITxzlsaMY0dpkQ7XCSa1oOLoUeaX33GiToc0Y7oaLumyztISH0PCz8sDsj7OXQJD5_OfXL5_ezq9Ecx-z09P_06K2ypZVU4xxwAZ1UJjXZQIzDZtvPaNg5Yycq5tBqtFFCCBmBMVroEYWtRcqml3CdH29RlDH9XeVfT-2Sx62DAsEqGl6rhSlVMZ_r5Fb0Pqzjk3TZKZCL0Rn3ZKhtDShHnZhnzj-LacGY2lZtcuXmsPNtPT4mrtkf3Ip87zuBkCx58h-u3k8zFt8vnyGI74dOI_14mIP4xVS1rZa5_Tc3Nz-Zmet1cGCn_A-oWmlc</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Rizzo, Giovanni</creator><creator>Manners, David</creator><creator>Testa, Claudia</creator><creator>Tonon, Caterina</creator><creator>Vetrugno, Roberto</creator><creator>Marconi, Sara</creator><creator>Plazzi, Giuseppe</creator><creator>Pizza, Fabio</creator><creator>Provini, Federica</creator><creator>Malucelli, Emil</creator><creator>Gramegna, Laura Ludovica</creator><creator>Lodi, Raffaele</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201311</creationdate><title>Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging</title><author>Rizzo, Giovanni ; Manners, David ; Testa, Claudia ; Tonon, Caterina ; Vetrugno, Roberto ; Marconi, Sara ; Plazzi, Giuseppe ; Pizza, Fabio ; Provini, Federica ; Malucelli, Emil ; Gramegna, Laura Ludovica ; Lodi, Raffaele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4836-dd0daa1064a98da7ea03bbf7c9da0404f3c8ec32a4a8aa003684a2c72413833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Brain - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>iron</topic><topic>Iron - metabolism</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Movement disorders</topic><topic>MRI</topic><topic>phase imaging</topic><topic>Restless Legs Syndrome - pathology</topic><topic>RLS</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rizzo, Giovanni</creatorcontrib><creatorcontrib>Manners, David</creatorcontrib><creatorcontrib>Testa, Claudia</creatorcontrib><creatorcontrib>Tonon, Caterina</creatorcontrib><creatorcontrib>Vetrugno, Roberto</creatorcontrib><creatorcontrib>Marconi, Sara</creatorcontrib><creatorcontrib>Plazzi, Giuseppe</creatorcontrib><creatorcontrib>Pizza, Fabio</creatorcontrib><creatorcontrib>Provini, Federica</creatorcontrib><creatorcontrib>Malucelli, Emil</creatorcontrib><creatorcontrib>Gramegna, Laura Ludovica</creatorcontrib><creatorcontrib>Lodi, Raffaele</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rizzo, Giovanni</au><au>Manners, David</au><au>Testa, Claudia</au><au>Tonon, Caterina</au><au>Vetrugno, Roberto</au><au>Marconi, Sara</au><au>Plazzi, Giuseppe</au><au>Pizza, Fabio</au><au>Provini, Federica</au><au>Malucelli, Emil</au><au>Gramegna, Laura Ludovica</au><au>Lodi, Raffaele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov Disord</addtitle><date>2013-11</date><risdate>2013</risdate><volume>28</volume><issue>13</issue><spage>1886</spage><epage>1890</epage><pages>1886-1890</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><coden>MOVDEA</coden><abstract>ABSTRACT
Background
The objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS).
Methods
Fifteen RLS patients and 15 healthy controls were studied using gradient‐echo imaging. Phase analysis was performed on localized brain regions of interest selected on phase maps, sensitive to paramagnetic tissue. Differences between the 2 subject groups were evaluated using ANCOVA including age as a covariate.
Results
Significantly higher phase values were present in the RLS patients compared with healthy controls at the level of the substantia nigra, thalamus, putamen, and pallidum, indicating reduced iron content in several regions of the brain of the patients.
Conclusions
We have used MRI phase analysis to study brain iron content in idiopathic RLS in vivo for the first time. Our results support the hypothesis of reduced brain iron content in RLS patients, which may have an important role in the pathophysiology of the disorder. © 2013 International Parkinson and Movement Disorder Society</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23780623</pmid><doi>10.1002/mds.25576</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Brain - metabolism Female Humans iron Iron - metabolism Magnetic Resonance Imaging Male Middle Aged Movement disorders MRI phase imaging Restless Legs Syndrome - pathology RLS Statistics, Nonparametric |
| title | Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging |
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