Acute, Bilateral, Concurrent Central Retinal Artery Occlusion in Sickle Cell Disease After Use of Tadalafil (Cialis)
IMPORTANCE Sickle cell disease (SCD) is characterized by vaso-occlusive crisis. In the eye, central retinal artery occlusion (CRAO) is a rare complication in SCD, with only 1 previous report of bilateral, concurrent CRAO. We report a case of bilateral, concurrent CRAO in a patient with SCD, possibly...
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| Veröffentlicht in: | JAMA ophthalmology 2013-11, Vol.131 (11), p.1471-1473 |
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| container_end_page | 1473 |
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| container_title | JAMA ophthalmology |
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| creator | Murthy, Ravi K Perez, Lizette Priluck, Joshua C Grover, Sandeep Chalam, Kakarla V |
| description | IMPORTANCE Sickle cell disease (SCD) is characterized by vaso-occlusive crisis. In the eye, central retinal artery occlusion (CRAO) is a rare complication in SCD, with only 1 previous report of bilateral, concurrent CRAO. We report a case of bilateral, concurrent CRAO in a patient with SCD, possibly precipitated by the use of phosphodiesterase 5 inhibitors. OBSERVATIONS A 37-year-old African American woman with a known medical history significant for SCD and pulmonary arterial hypertension who was receiving treatment with tadalafil, a phosphodiesterase 5 inhibitor, developed bilateral, concurrent CRAO that persisted after exchange transfusion. CONCLUSIONS AND RELEVANCE Bilateral CRAO secondary to SCD is extremely rare, with only 1 previous case report in the literature. The use of phosphodiesterase 5 inhibitors is an additional risk factor and may have contributed to the development of concurrent CRAO in this patient. |
| doi_str_mv | 10.1001/jamaophthalmol.2013.5047 |
| format | Article |
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In the eye, central retinal artery occlusion (CRAO) is a rare complication in SCD, with only 1 previous report of bilateral, concurrent CRAO. We report a case of bilateral, concurrent CRAO in a patient with SCD, possibly precipitated by the use of phosphodiesterase 5 inhibitors. OBSERVATIONS A 37-year-old African American woman with a known medical history significant for SCD and pulmonary arterial hypertension who was receiving treatment with tadalafil, a phosphodiesterase 5 inhibitor, developed bilateral, concurrent CRAO that persisted after exchange transfusion. CONCLUSIONS AND RELEVANCE Bilateral CRAO secondary to SCD is extremely rare, with only 1 previous case report in the literature. The use of phosphodiesterase 5 inhibitors is an additional risk factor and may have contributed to the development of concurrent CRAO in this patient.</description><identifier>ISSN: 2168-6165</identifier><identifier>EISSN: 2168-6173</identifier><identifier>DOI: 10.1001/jamaophthalmol.2013.5047</identifier><identifier>PMID: 24052082</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Acute Disease ; Adult ; Anemia, Sickle Cell - complications ; Anemia, Sickle Cell - drug therapy ; Carbolines - adverse effects ; Familial Primary Pulmonary Hypertension ; Female ; Fluorescein Angiography ; Humans ; Hypertension, Pulmonary - complications ; Hypertension, Pulmonary - drug therapy ; Papilledema - chemically induced ; Papilledema - diagnosis ; Phosphodiesterase 5 Inhibitors - adverse effects ; Retinal Artery Occlusion - chemically induced ; Retinal Artery Occlusion - diagnosis ; Tadalafil ; Tomography, Optical Coherence</subject><ispartof>JAMA ophthalmology, 2013-11, Vol.131 (11), p.1471-1473</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a334t-bd0ee39a7c4853bd3713300446c5fdc8d31fcd0d9aae0caa3e649ffb4849f7623</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamaophthalmology/articlepdf/10.1001/jamaophthalmol.2013.5047$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/jamaophthalmol.2013.5047$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,315,781,785,3341,27929,27930,76494,76497</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24052082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murthy, Ravi K</creatorcontrib><creatorcontrib>Perez, Lizette</creatorcontrib><creatorcontrib>Priluck, Joshua C</creatorcontrib><creatorcontrib>Grover, Sandeep</creatorcontrib><creatorcontrib>Chalam, Kakarla V</creatorcontrib><title>Acute, Bilateral, Concurrent Central Retinal Artery Occlusion in Sickle Cell Disease After Use of Tadalafil (Cialis)</title><title>JAMA ophthalmology</title><addtitle>JAMA Ophthalmol</addtitle><description>IMPORTANCE Sickle cell disease (SCD) is characterized by vaso-occlusive crisis. In the eye, central retinal artery occlusion (CRAO) is a rare complication in SCD, with only 1 previous report of bilateral, concurrent CRAO. We report a case of bilateral, concurrent CRAO in a patient with SCD, possibly precipitated by the use of phosphodiesterase 5 inhibitors. OBSERVATIONS A 37-year-old African American woman with a known medical history significant for SCD and pulmonary arterial hypertension who was receiving treatment with tadalafil, a phosphodiesterase 5 inhibitor, developed bilateral, concurrent CRAO that persisted after exchange transfusion. CONCLUSIONS AND RELEVANCE Bilateral CRAO secondary to SCD is extremely rare, with only 1 previous case report in the literature. The use of phosphodiesterase 5 inhibitors is an additional risk factor and may have contributed to the development of concurrent CRAO in this patient.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Anemia, Sickle Cell - drug therapy</subject><subject>Carbolines - adverse effects</subject><subject>Familial Primary Pulmonary Hypertension</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - complications</subject><subject>Hypertension, Pulmonary - drug therapy</subject><subject>Papilledema - chemically induced</subject><subject>Papilledema - diagnosis</subject><subject>Phosphodiesterase 5 Inhibitors - adverse effects</subject><subject>Retinal Artery Occlusion - chemically induced</subject><subject>Retinal Artery Occlusion - diagnosis</subject><subject>Tadalafil</subject><subject>Tomography, Optical Coherence</subject><issn>2168-6165</issn><issn>2168-6173</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LAzEQhoMoKrV_wIPkqGBrskn241jXTxAK2p6XaTbBaHa3JruH_nuntCrmMO8QnnkneQmhnE05Y_zmAxro1u_9O_im89OEcTFVTGYH5DThaT5JeSYOf_tUnZBxjB8MT86YFOqYnCSSqYTlySnpZ3rozTW9dR56E8Bf07Jr9RCCaXtaYsE7-mp616LOAjIbOtfaD9F1LXUtfXP60xtEvad3LhqIhs4scnSJXWfpAmrwYJ2nl6UD7-LVGTmy4KMZ73VElg_3i_Jp8jJ_fC5nLxMQQvaTVc2MEQVkWuZKrGqRcSHwCzLVytY6rwW3umZ1AWCYBhAmlYW1K5mjZGkiRuRy57sO3ddgYl81Lmp8KLSmG2LFpSq4whwEovkO1aGLMRhbrYNrIGwqzqpt7NX_2Ktt7NU2dhy92G8ZVo2pfwd_QkbgfAegw59tJgqF5Ru8CIs1</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Murthy, Ravi K</creator><creator>Perez, Lizette</creator><creator>Priluck, Joshua C</creator><creator>Grover, Sandeep</creator><creator>Chalam, Kakarla V</creator><general>American Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131101</creationdate><title>Acute, Bilateral, Concurrent Central Retinal Artery Occlusion in Sickle Cell Disease After Use of Tadalafil (Cialis)</title><author>Murthy, Ravi K ; Perez, Lizette ; Priluck, Joshua C ; Grover, Sandeep ; Chalam, Kakarla V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a334t-bd0ee39a7c4853bd3713300446c5fdc8d31fcd0d9aae0caa3e649ffb4849f7623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Anemia, Sickle Cell - drug therapy</topic><topic>Carbolines - adverse effects</topic><topic>Familial Primary Pulmonary Hypertension</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - complications</topic><topic>Hypertension, Pulmonary - drug therapy</topic><topic>Papilledema - chemically induced</topic><topic>Papilledema - diagnosis</topic><topic>Phosphodiesterase 5 Inhibitors - adverse effects</topic><topic>Retinal Artery Occlusion - chemically induced</topic><topic>Retinal Artery Occlusion - diagnosis</topic><topic>Tadalafil</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murthy, Ravi K</creatorcontrib><creatorcontrib>Perez, Lizette</creatorcontrib><creatorcontrib>Priluck, Joshua C</creatorcontrib><creatorcontrib>Grover, Sandeep</creatorcontrib><creatorcontrib>Chalam, Kakarla V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JAMA ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murthy, Ravi K</au><au>Perez, Lizette</au><au>Priluck, Joshua C</au><au>Grover, Sandeep</au><au>Chalam, Kakarla V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute, Bilateral, Concurrent Central Retinal Artery Occlusion in Sickle Cell Disease After Use of Tadalafil (Cialis)</atitle><jtitle>JAMA ophthalmology</jtitle><addtitle>JAMA Ophthalmol</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>131</volume><issue>11</issue><spage>1471</spage><epage>1473</epage><pages>1471-1473</pages><issn>2168-6165</issn><eissn>2168-6173</eissn><abstract>IMPORTANCE Sickle cell disease (SCD) is characterized by vaso-occlusive crisis. In the eye, central retinal artery occlusion (CRAO) is a rare complication in SCD, with only 1 previous report of bilateral, concurrent CRAO. We report a case of bilateral, concurrent CRAO in a patient with SCD, possibly precipitated by the use of phosphodiesterase 5 inhibitors. OBSERVATIONS A 37-year-old African American woman with a known medical history significant for SCD and pulmonary arterial hypertension who was receiving treatment with tadalafil, a phosphodiesterase 5 inhibitor, developed bilateral, concurrent CRAO that persisted after exchange transfusion. CONCLUSIONS AND RELEVANCE Bilateral CRAO secondary to SCD is extremely rare, with only 1 previous case report in the literature. The use of phosphodiesterase 5 inhibitors is an additional risk factor and may have contributed to the development of concurrent CRAO in this patient.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>24052082</pmid><doi>10.1001/jamaophthalmol.2013.5047</doi><tpages>3</tpages></addata></record> |
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| subjects | Acute Disease Adult Anemia, Sickle Cell - complications Anemia, Sickle Cell - drug therapy Carbolines - adverse effects Familial Primary Pulmonary Hypertension Female Fluorescein Angiography Humans Hypertension, Pulmonary - complications Hypertension, Pulmonary - drug therapy Papilledema - chemically induced Papilledema - diagnosis Phosphodiesterase 5 Inhibitors - adverse effects Retinal Artery Occlusion - chemically induced Retinal Artery Occlusion - diagnosis Tadalafil Tomography, Optical Coherence |
| title | Acute, Bilateral, Concurrent Central Retinal Artery Occlusion in Sickle Cell Disease After Use of Tadalafil (Cialis) |
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