Peritoneal carcinomatosis of gastric origin: A population‐based study on incidence, survival and risk factors
Peritoneal carcinomatosis (PC) is an important cause of morbidity and mortality among patients with gastric cancer. The aim of the current study was to provide reliable population‐based data on the incidence, risk factors and prognosis of PC of gastric origin. All patients diagnosed with gastric can...
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| Veröffentlicht in: | International journal of cancer 2014-02, Vol.134 (3), p.622-628 |
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| creator | Thomassen, Irene Gestel, Yvette R. Ramshorst, Bert Luyer, Misha D. Bosscha, Koop Nienhuijs, Simon W. Lemmens, Valery E. Hingh, Ignace H. |
| description | Peritoneal carcinomatosis (PC) is an important cause of morbidity and mortality among patients with gastric cancer. The aim of the current study was to provide reliable population‐based data on the incidence, risk factors and prognosis of PC of gastric origin. All patients diagnosed with gastric cancer in the area of the Eindhoven Cancer Registry between 1995 and 2011 were included. Incidence and survival were computed and risk factors for peritoneal carcinomatosis were determined using multivariate logistic regression analysis. In total, 5,220 patients were diagnosed with gastric cancer, of whom 2,029 (39%) presented with metastatic disease. PC was present in 706 patients (14%) of whom 491 patients (9%) had PC as the only metastatic site. Younger age ( |
| doi_str_mv | 10.1002/ijc.28373 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1459149294</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3125874291</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4843-5a9cebd6298618dfa79be30666c9bdec82c0c7725d105df9dbb0ee3309e916073</originalsourceid><addsrcrecordid>eNp10d9qFDEUBvAgFrtWL3wBCYig4LQnycwk6V1Z_NNS0Au9HjJJpmSdTdacmcre-Qg-Y5_ErLsqFLzKxfnxnXA-Qp4xOGUA_Cys7ClXQooHZMFAywo4ax6SRZlBJZloj8ljxBUAYw3Uj8gxF0pwVcsFSZ98DlOK3ozUmmxDTGszJQxI00BvDE45WJpyuAnxnF7QTdrMo5lCinc_fvYGvaM4zW5LU6Qh2uB8tP4NxTnfhtuSaaKjOeBXOhg7pYxPyNFgRvRPD-8J-fLu7eflh-r64_vL5cV1ZWtVi6ox2vretVyrlik3GKl7L6BtW6t7563iFqyUvHEMGjdo1_fgvRCgvWYtSHFCXu1zNzl9mz1O3Tqg9eNook8zdqxuNKs113WhL-7RVZpzLL_bKVkrzjUU9XqvbE6I2Q_dJoe1yduOQbdroSstdL9bKPb5IXHu1979lX_OXsDLAzBozThkU06H_5ziANDs3NnefQ-j3_5_Y3d5tdyv_gXvLp-A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1457482290</pqid></control><display><type>article</type><title>Peritoneal carcinomatosis of gastric origin: A population‐based study on incidence, survival and risk factors</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Thomassen, Irene ; Gestel, Yvette R. ; Ramshorst, Bert ; Luyer, Misha D. ; Bosscha, Koop ; Nienhuijs, Simon W. ; Lemmens, Valery E. ; Hingh, Ignace H.</creator><creatorcontrib>Thomassen, Irene ; Gestel, Yvette R. ; Ramshorst, Bert ; Luyer, Misha D. ; Bosscha, Koop ; Nienhuijs, Simon W. ; Lemmens, Valery E. ; Hingh, Ignace H.</creatorcontrib><description>Peritoneal carcinomatosis (PC) is an important cause of morbidity and mortality among patients with gastric cancer. The aim of the current study was to provide reliable population‐based data on the incidence, risk factors and prognosis of PC of gastric origin. All patients diagnosed with gastric cancer in the area of the Eindhoven Cancer Registry between 1995 and 2011 were included. Incidence and survival were computed and risk factors for peritoneal carcinomatosis were determined using multivariate logistic regression analysis. In total, 5,220 patients were diagnosed with gastric cancer, of whom 2,029 (39%) presented with metastatic disease. PC was present in 706 patients (14%) of whom 491 patients (9%) had PC as the only metastatic site. Younger age (<60 years), female gender, advanced T‐ and N‐stage, primary tumor of signet ring cells or linitis plastica and primary tumors covering multiple anatomical locations of the stomach were all associated with a higher odds ratios of developing PC. Median survival of patients without metastases was 14 months, but only 4 months for patients with PC. PC is a frequent condition in patients presenting with gastric cancer, especially in younger patients with advanced tumor stages. Given the detrimental influence of PC on survival, efforts should be undertaken to further explore the promising results that were obtained in preventing or treating this condition with multimodality strategies.
What's new?
Until recently, peritoneal carcinomatosis (PC), in which malignant ascites forms in the peritoneum, was considered to be an untreatable condition. But new treatment options have raised hope for improved survival, as well as created a need to better understand risk factors and prevention. Here, analysis of data from the Eindhoven Cancer Registry from 1995–2011 reveals that more than one‐third of patients with metastatic gastric cancer presented with PC. Younger patients and females with advanced disease were at greatest risk for this condition. The findings may have implications for PC diagnosis and treatment.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.28373</identifier><identifier>PMID: 23832847</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley-Blackwell</publisher><subject>Abdomen ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Cancer ; Female ; Gastric cancer ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Incidence ; Male ; Medical prognosis ; Medical research ; Medical sciences ; metastasis ; Middle Aged ; Mortality ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Netherlands - epidemiology ; peritoneal carcinomatosis ; Peritoneal Neoplasms - epidemiology ; Peritoneal Neoplasms - secondary ; Population Surveillance ; prognosis ; Registries ; Risk Factors ; Stomach Neoplasms - epidemiology ; Stomach Neoplasms - pathology ; Survival Rate ; treatment ; Tumors</subject><ispartof>International journal of cancer, 2014-02, Vol.134 (3), p.622-628</ispartof><rights>Copyright © 2013 UICC</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 UICC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4843-5a9cebd6298618dfa79be30666c9bdec82c0c7725d105df9dbb0ee3309e916073</citedby><cites>FETCH-LOGICAL-c4843-5a9cebd6298618dfa79be30666c9bdec82c0c7725d105df9dbb0ee3309e916073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.28373$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.28373$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28200057$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23832847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thomassen, Irene</creatorcontrib><creatorcontrib>Gestel, Yvette R.</creatorcontrib><creatorcontrib>Ramshorst, Bert</creatorcontrib><creatorcontrib>Luyer, Misha D.</creatorcontrib><creatorcontrib>Bosscha, Koop</creatorcontrib><creatorcontrib>Nienhuijs, Simon W.</creatorcontrib><creatorcontrib>Lemmens, Valery E.</creatorcontrib><creatorcontrib>Hingh, Ignace H.</creatorcontrib><title>Peritoneal carcinomatosis of gastric origin: A population‐based study on incidence, survival and risk factors</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Peritoneal carcinomatosis (PC) is an important cause of morbidity and mortality among patients with gastric cancer. The aim of the current study was to provide reliable population‐based data on the incidence, risk factors and prognosis of PC of gastric origin. All patients diagnosed with gastric cancer in the area of the Eindhoven Cancer Registry between 1995 and 2011 were included. Incidence and survival were computed and risk factors for peritoneal carcinomatosis were determined using multivariate logistic regression analysis. In total, 5,220 patients were diagnosed with gastric cancer, of whom 2,029 (39%) presented with metastatic disease. PC was present in 706 patients (14%) of whom 491 patients (9%) had PC as the only metastatic site. Younger age (<60 years), female gender, advanced T‐ and N‐stage, primary tumor of signet ring cells or linitis plastica and primary tumors covering multiple anatomical locations of the stomach were all associated with a higher odds ratios of developing PC. Median survival of patients without metastases was 14 months, but only 4 months for patients with PC. PC is a frequent condition in patients presenting with gastric cancer, especially in younger patients with advanced tumor stages. Given the detrimental influence of PC on survival, efforts should be undertaken to further explore the promising results that were obtained in preventing or treating this condition with multimodality strategies.
What's new?
Until recently, peritoneal carcinomatosis (PC), in which malignant ascites forms in the peritoneum, was considered to be an untreatable condition. But new treatment options have raised hope for improved survival, as well as created a need to better understand risk factors and prevention. Here, analysis of data from the Eindhoven Cancer Registry from 1995–2011 reveals that more than one‐third of patients with metastatic gastric cancer presented with PC. Younger patients and females with advanced disease were at greatest risk for this condition. The findings may have implications for PC diagnosis and treatment.</description><subject>Abdomen</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>metastasis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Netherlands - epidemiology</subject><subject>peritoneal carcinomatosis</subject><subject>Peritoneal Neoplasms - epidemiology</subject><subject>Peritoneal Neoplasms - secondary</subject><subject>Population Surveillance</subject><subject>prognosis</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Stomach Neoplasms - epidemiology</subject><subject>Stomach Neoplasms - pathology</subject><subject>Survival Rate</subject><subject>treatment</subject><subject>Tumors</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10d9qFDEUBvAgFrtWL3wBCYig4LQnycwk6V1Z_NNS0Au9HjJJpmSdTdacmcre-Qg-Y5_ErLsqFLzKxfnxnXA-Qp4xOGUA_Cys7ClXQooHZMFAywo4ax6SRZlBJZloj8ljxBUAYw3Uj8gxF0pwVcsFSZ98DlOK3ozUmmxDTGszJQxI00BvDE45WJpyuAnxnF7QTdrMo5lCinc_fvYGvaM4zW5LU6Qh2uB8tP4NxTnfhtuSaaKjOeBXOhg7pYxPyNFgRvRPD-8J-fLu7eflh-r64_vL5cV1ZWtVi6ox2vretVyrlik3GKl7L6BtW6t7563iFqyUvHEMGjdo1_fgvRCgvWYtSHFCXu1zNzl9mz1O3Tqg9eNook8zdqxuNKs113WhL-7RVZpzLL_bKVkrzjUU9XqvbE6I2Q_dJoe1yduOQbdroSstdL9bKPb5IXHu1979lX_OXsDLAzBozThkU06H_5ziANDs3NnefQ-j3_5_Y3d5tdyv_gXvLp-A</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Thomassen, Irene</creator><creator>Gestel, Yvette R.</creator><creator>Ramshorst, Bert</creator><creator>Luyer, Misha D.</creator><creator>Bosscha, Koop</creator><creator>Nienhuijs, Simon W.</creator><creator>Lemmens, Valery E.</creator><creator>Hingh, Ignace H.</creator><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20140201</creationdate><title>Peritoneal carcinomatosis of gastric origin: A population‐based study on incidence, survival and risk factors</title><author>Thomassen, Irene ; Gestel, Yvette R. ; Ramshorst, Bert ; Luyer, Misha D. ; Bosscha, Koop ; Nienhuijs, Simon W. ; Lemmens, Valery E. ; Hingh, Ignace H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4843-5a9cebd6298618dfa79be30666c9bdec82c0c7725d105df9dbb0ee3309e916073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Abdomen</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>metastasis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Netherlands - epidemiology</topic><topic>peritoneal carcinomatosis</topic><topic>Peritoneal Neoplasms - epidemiology</topic><topic>Peritoneal Neoplasms - secondary</topic><topic>Population Surveillance</topic><topic>prognosis</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Stomach Neoplasms - epidemiology</topic><topic>Stomach Neoplasms - pathology</topic><topic>Survival Rate</topic><topic>treatment</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thomassen, Irene</creatorcontrib><creatorcontrib>Gestel, Yvette R.</creatorcontrib><creatorcontrib>Ramshorst, Bert</creatorcontrib><creatorcontrib>Luyer, Misha D.</creatorcontrib><creatorcontrib>Bosscha, Koop</creatorcontrib><creatorcontrib>Nienhuijs, Simon W.</creatorcontrib><creatorcontrib>Lemmens, Valery E.</creatorcontrib><creatorcontrib>Hingh, Ignace H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thomassen, Irene</au><au>Gestel, Yvette R.</au><au>Ramshorst, Bert</au><au>Luyer, Misha D.</au><au>Bosscha, Koop</au><au>Nienhuijs, Simon W.</au><au>Lemmens, Valery E.</au><au>Hingh, Ignace H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peritoneal carcinomatosis of gastric origin: A population‐based study on incidence, survival and risk factors</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>134</volume><issue>3</issue><spage>622</spage><epage>628</epage><pages>622-628</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>Peritoneal carcinomatosis (PC) is an important cause of morbidity and mortality among patients with gastric cancer. The aim of the current study was to provide reliable population‐based data on the incidence, risk factors and prognosis of PC of gastric origin. All patients diagnosed with gastric cancer in the area of the Eindhoven Cancer Registry between 1995 and 2011 were included. Incidence and survival were computed and risk factors for peritoneal carcinomatosis were determined using multivariate logistic regression analysis. In total, 5,220 patients were diagnosed with gastric cancer, of whom 2,029 (39%) presented with metastatic disease. PC was present in 706 patients (14%) of whom 491 patients (9%) had PC as the only metastatic site. Younger age (<60 years), female gender, advanced T‐ and N‐stage, primary tumor of signet ring cells or linitis plastica and primary tumors covering multiple anatomical locations of the stomach were all associated with a higher odds ratios of developing PC. Median survival of patients without metastases was 14 months, but only 4 months for patients with PC. PC is a frequent condition in patients presenting with gastric cancer, especially in younger patients with advanced tumor stages. Given the detrimental influence of PC on survival, efforts should be undertaken to further explore the promising results that were obtained in preventing or treating this condition with multimodality strategies.
What's new?
Until recently, peritoneal carcinomatosis (PC), in which malignant ascites forms in the peritoneum, was considered to be an untreatable condition. But new treatment options have raised hope for improved survival, as well as created a need to better understand risk factors and prevention. Here, analysis of data from the Eindhoven Cancer Registry from 1995–2011 reveals that more than one‐third of patients with metastatic gastric cancer presented with PC. Younger patients and females with advanced disease were at greatest risk for this condition. The findings may have implications for PC diagnosis and treatment.</abstract><cop>Hoboken, NJ</cop><pub>Wiley-Blackwell</pub><pmid>23832847</pmid><doi>10.1002/ijc.28373</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals |
| subjects | Abdomen Aged Aged, 80 and over Biological and medical sciences Cancer Female Gastric cancer Gastroenterology. Liver. Pancreas. Abdomen Humans Incidence Male Medical prognosis Medical research Medical sciences metastasis Middle Aged Mortality Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Netherlands - epidemiology peritoneal carcinomatosis Peritoneal Neoplasms - epidemiology Peritoneal Neoplasms - secondary Population Surveillance prognosis Registries Risk Factors Stomach Neoplasms - epidemiology Stomach Neoplasms - pathology Survival Rate treatment Tumors |
| title | Peritoneal carcinomatosis of gastric origin: A population‐based study on incidence, survival and risk factors |
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