Administration of Interleukin-17 Soluble Receptor C Suppresses TH17 Cells, Oxidative Stress, and Hypertension in Response to Placental Ischemia During Pregnancy

Preeclampsia, new onset hypertension with proteinuria during pregnancy, is associated with chronic inflammation and placental oxidative stress (ROS). Chronic interleukin-17 (IL-17) increases blood pressure, autoantibodies (angiotensin II type I receptor [AT1-AA]), and ROS during pregnancy. The objec...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2013-12, Vol.62 (6), p.1068-1073
Hauptverfasser:	CORNELIUS, Denise C, HOGG, James P, SCOTT, Jeremy, WALLACE, Kedra, HERSE, Florian, MOSELEY, Janae, WALLUKAT, Gerd, DECHEND, Ralf, LAMARCA, Babbette
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Female Hypertension - etiology Hypertension - immunology Hypertension - metabolism Interleukin-17 - metabolism Ischemia - complications Ischemia - immunology Ischemia - metabolism Medical sciences Oxidative Stress - drug effects Oxidative Stress - immunology Placenta - blood supply Placenta - immunology Placenta - metabolism Pregnancy Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Receptors, Interleukin-17 - administration & dosage Receptors, Interleukin-17 - metabolism Th17 Cells - drug effects Th17 Cells - immunology Th17 Cells - metabolism
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