Receptor protection experiments confirm the identity of presynaptic alpha sub(2)-autoreceptors

Receptor protection experiments confirm the identity of presynaptic alpha sub(2)-autoreceptors

Receptor protection experiments were carried out in cerebrocortical slices from rabbits in order to study the sites at which drugs with alpha -adrenoceptor affinity modulate the release of noradrenaline. The slices were preincubated with super(3)H-noradrenaline. Phenoxybenzamine was added from 85 to...

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Veröffentlicht in:Naunyn-Schmiedeberg's archives of pharmacology 1986-01, Vol.333 (3), p.262-270
Hauptverfasser: Hoelting, T, Starke, K
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creator Hoelting, T
Starke, K
description Receptor protection experiments were carried out in cerebrocortical slices from rabbits in order to study the sites at which drugs with alpha -adrenoceptor affinity modulate the release of noradrenaline. The slices were preincubated with super(3)H-noradrenaline. Phenoxybenzamine was added from 85 to 95 min of superfusion. Potential protecting drugs were present for 5 min before and during the exposure to phenoxybenzamine and then washed out together with the latter. It is concluded that drugs with affinity for alpha sub(2)-adrenoceptors protect the noradrenergic axons of rabbit brain cortex against the long-lasting release-enhancing effect of phenoxybenzamine.
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title Receptor protection experiments confirm the identity of presynaptic alpha sub(2)-autoreceptors
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