The immunomodulating agent gliotoxin causes genomic DNA fragmentation

Gliotoxin, a member of the class of secondary fungal metabolites characterized by the presence of an epipolythiodioxopiperazine ring, caused fragmentation of spleen cell DNA as observed by flow cytometry and gel electrophoresis. Gliotoxin was found to cause substantial double-stranded DNA breakage i...

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Veröffentlicht in:	Molecular immunology 1987, Vol.24 (1), p.47-55
Hauptverfasser:	Braithwaite, Antony W., Eichner, Ronald D., Waring, Paul, Müllbacher, Arno
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division - drug effects DNA - biosynthesis DNA - radiation effects DNA Damage Dose-Response Relationship, Drug Electrophoresis, Agar Gel Genes Gliotoxin - metabolism Gliotoxin - pharmacology Immune Tolerance - drug effects Lymphocyte Activation - drug effects Mice Mycotoxins - pharmacology Spleen - cytology Sporidesmins - pharmacology
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