Humoral and Cellular Immunity in Chromium Picolinate-Supplemented Lambs
The effects of oral supplementation of chromium picolinate (CrPic) on humoral and cellular immunity in sheep were investigated. Twenty-four male lambs divided into four treatments and received different dosages of CrPic: placebo (0), 0.250, 0.375, and 0.500 mg of chromium/animal/day during 84 days....
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| Veröffentlicht in: | Biological trace element research 2013-08, Vol.154 (2), p.196-201 |
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| creator | Dallago, B. S. L McManus, C. M Caldeira, D. F Campeche, A Burtet, R. T Paim, T. P Gomes, E. F Branquinho, R. P Braz, S. V Louvandini, H |
| description | The effects of oral supplementation of chromium picolinate (CrPic) on humoral and cellular immunity in sheep were investigated. Twenty-four male lambs divided into four treatments and received different dosages of CrPic: placebo (0), 0.250, 0.375, and 0.500 mg of chromium/animal/day during 84 days. The base ration was Panicum maximum cv Massai hay and concentrate. Blood samples were collected fortnightly for total and differential leukocyte counts. On days 28 and 56, the lambs were challenged with chicken ovalbumin I.M. Serum samples were collected on days 46 and 74 and subjected to an indirect enzyme-linked immunosorbent assay to measure IgG anti-ovalbumin. The cell-mediated immune response was determined by a delay-type hypersensitivity test using phytohemagglutinin. CrPic did not significantly affect humoral immunity in lambs but there was a negative effect on cellular immunity (P |
| doi_str_mv | 10.1007/s12011-013-9731-7 |
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S. L ; McManus, C. M ; Caldeira, D. F ; Campeche, A ; Burtet, R. T ; Paim, T. P ; Gomes, E. F ; Branquinho, R. P ; Braz, S. V ; Louvandini, H</creator><creatorcontrib>Dallago, B. S. L ; McManus, C. M ; Caldeira, D. F ; Campeche, A ; Burtet, R. T ; Paim, T. P ; Gomes, E. F ; Branquinho, R. P ; Braz, S. V ; Louvandini, H</creatorcontrib><description>The effects of oral supplementation of chromium picolinate (CrPic) on humoral and cellular immunity in sheep were investigated. Twenty-four male lambs divided into four treatments and received different dosages of CrPic: placebo (0), 0.250, 0.375, and 0.500 mg of chromium/animal/day during 84 days. The base ration was Panicum maximum cv Massai hay and concentrate. Blood samples were collected fortnightly for total and differential leukocyte counts. On days 28 and 56, the lambs were challenged with chicken ovalbumin I.M. Serum samples were collected on days 46 and 74 and subjected to an indirect enzyme-linked immunosorbent assay to measure IgG anti-ovalbumin. The cell-mediated immune response was determined by a delay-type hypersensitivity test using phytohemagglutinin. CrPic did not significantly affect humoral immunity in lambs but there was a negative effect on cellular immunity (P < 0.05) as Cr supplementation increased. Therefore, the level of Cr supplementation for lambs must be better studied to address its effect on stressed animals or the possible toxic effects of Cr on the animal itself or its immune system.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-013-9731-7</identifier><identifier>PMID: 23797575</identifier><language>eng</language><publisher>Boston: Springer-Verlag</publisher><subject>Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedical research ; Biotechnology ; blood serum ; cell-mediated immunity ; chickens ; Chromium ; Dietary minerals ; Dietary Supplements ; enzyme-linked immunosorbent assay ; hay ; humoral immunity ; Hypersensitivity ; Hypersensitivity, Delayed - blood ; Hypersensitivity, Delayed - immunology ; Immune response ; Immune system ; Immunity (Disease) ; Immunity, Cellular - drug effects ; Immunity, Humoral - drug effects ; immunoglobulin G ; Immunoglobulin G - blood ; Immunoglobulin G - immunology ; Iron Chelating Agents - pharmacology ; lambs ; Life Sciences ; Male ; Nutrition ; Oncology ; ovalbumin ; Panicum maximum ; phytohemagglutinin ; Picolinic Acids - pharmacology ; Sheep ; toxicity</subject><ispartof>Biological trace element research, 2013-08, Vol.154 (2), p.196-201</ispartof><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-152d7525d6c69889fd71f60bca61fb0984ffa03239304e2077857afdd342d3703</citedby><cites>FETCH-LOGICAL-c429t-152d7525d6c69889fd71f60bca61fb0984ffa03239304e2077857afdd342d3703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-013-9731-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-013-9731-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23797575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dallago, B. S. L</creatorcontrib><creatorcontrib>McManus, C. M</creatorcontrib><creatorcontrib>Caldeira, D. F</creatorcontrib><creatorcontrib>Campeche, A</creatorcontrib><creatorcontrib>Burtet, R. T</creatorcontrib><creatorcontrib>Paim, T. P</creatorcontrib><creatorcontrib>Gomes, E. F</creatorcontrib><creatorcontrib>Branquinho, R. P</creatorcontrib><creatorcontrib>Braz, S. V</creatorcontrib><creatorcontrib>Louvandini, H</creatorcontrib><title>Humoral and Cellular Immunity in Chromium Picolinate-Supplemented Lambs</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>The effects of oral supplementation of chromium picolinate (CrPic) on humoral and cellular immunity in sheep were investigated. Twenty-four male lambs divided into four treatments and received different dosages of CrPic: placebo (0), 0.250, 0.375, and 0.500 mg of chromium/animal/day during 84 days. The base ration was Panicum maximum cv Massai hay and concentrate. Blood samples were collected fortnightly for total and differential leukocyte counts. On days 28 and 56, the lambs were challenged with chicken ovalbumin I.M. Serum samples were collected on days 46 and 74 and subjected to an indirect enzyme-linked immunosorbent assay to measure IgG anti-ovalbumin. The cell-mediated immune response was determined by a delay-type hypersensitivity test using phytohemagglutinin. CrPic did not significantly affect humoral immunity in lambs but there was a negative effect on cellular immunity (P < 0.05) as Cr supplementation increased. Therefore, the level of Cr supplementation for lambs must be better studied to address its effect on stressed animals or the possible toxic effects of Cr on the animal itself or its immune system.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical research</subject><subject>Biotechnology</subject><subject>blood serum</subject><subject>cell-mediated immunity</subject><subject>chickens</subject><subject>Chromium</subject><subject>Dietary minerals</subject><subject>Dietary Supplements</subject><subject>enzyme-linked immunosorbent assay</subject><subject>hay</subject><subject>humoral immunity</subject><subject>Hypersensitivity</subject><subject>Hypersensitivity, Delayed - blood</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity (Disease)</subject><subject>Immunity, Cellular - drug effects</subject><subject>Immunity, Humoral - drug effects</subject><subject>immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - immunology</subject><subject>Iron Chelating Agents - pharmacology</subject><subject>lambs</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>ovalbumin</subject><subject>Panicum maximum</subject><subject>phytohemagglutinin</subject><subject>Picolinic Acids - pharmacology</subject><subject>Sheep</subject><subject>toxicity</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1vFSEYhYnR2Gv1B7jRSdy4Qd-XjwGW5kbbJjfRpHZNuAPUaYaZKwyL_ntpphrjwhULnnM4eSDkNcIHBFAfCzJApICcGsWRqidkh1IaCorBU7ID7DkVRosz8qKUOwBUzPDn5IxxZZRUckcuLmtasps6N_tuH6apTi53VynVeVzvu3Hu9j_yksaaum_jsEzj7NZAr-vpNIUU5jX47uDSsbwkz6KbSnj1eJ6Tmy-fv-8v6eHrxdX-04EOgpmVomReSSZ9P_RGaxO9wtjDcXA9xiO0qTE64IwbDiIwUEpL5aL3XDDPFfBz8n7rPeXlZw1ltWksQ9vt5rDUYlFILYWSwjT03T_o3VLz3NZZ5EYz2Td5jcKNGvJSSg7RnvKYXL63CPbBst0s22bZPli2qmXePDbXYwr-T-K31gawDSjtar4N-a-n_9P6dgtFt1h3m8dib64bJNq_aalB81-eb46f</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Dallago, B. 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S. L</au><au>McManus, C. M</au><au>Caldeira, D. F</au><au>Campeche, A</au><au>Burtet, R. T</au><au>Paim, T. P</au><au>Gomes, E. F</au><au>Branquinho, R. P</au><au>Braz, S. V</au><au>Louvandini, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Humoral and Cellular Immunity in Chromium Picolinate-Supplemented Lambs</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>154</volume><issue>2</issue><spage>196</spage><epage>201</epage><pages>196-201</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>The effects of oral supplementation of chromium picolinate (CrPic) on humoral and cellular immunity in sheep were investigated. Twenty-four male lambs divided into four treatments and received different dosages of CrPic: placebo (0), 0.250, 0.375, and 0.500 mg of chromium/animal/day during 84 days. The base ration was Panicum maximum cv Massai hay and concentrate. Blood samples were collected fortnightly for total and differential leukocyte counts. On days 28 and 56, the lambs were challenged with chicken ovalbumin I.M. Serum samples were collected on days 46 and 74 and subjected to an indirect enzyme-linked immunosorbent assay to measure IgG anti-ovalbumin. The cell-mediated immune response was determined by a delay-type hypersensitivity test using phytohemagglutinin. CrPic did not significantly affect humoral immunity in lambs but there was a negative effect on cellular immunity (P < 0.05) as Cr supplementation increased. Therefore, the level of Cr supplementation for lambs must be better studied to address its effect on stressed animals or the possible toxic effects of Cr on the animal itself or its immune system.</abstract><cop>Boston</cop><pub>Springer-Verlag</pub><pmid>23797575</pmid><doi>10.1007/s12011-013-9731-7</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biochemistry Biomedical and Life Sciences Biomedical research Biotechnology blood serum cell-mediated immunity chickens Chromium Dietary minerals Dietary Supplements enzyme-linked immunosorbent assay hay humoral immunity Hypersensitivity Hypersensitivity, Delayed - blood Hypersensitivity, Delayed - immunology Immune response Immune system Immunity (Disease) Immunity, Cellular - drug effects Immunity, Humoral - drug effects immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Iron Chelating Agents - pharmacology lambs Life Sciences Male Nutrition Oncology ovalbumin Panicum maximum phytohemagglutinin Picolinic Acids - pharmacology Sheep toxicity |
| title | Humoral and Cellular Immunity in Chromium Picolinate-Supplemented Lambs |
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