Optineurin suppression causes neuronal cell death via NF‐κB pathway

Mutations in more than 10 genes are reported to cause familial amyotrophic lateral sclerosis (ALS). Among these genes, optineurin (OPTN) is virtually the only gene that is considered to cause classical ALS by a loss‐of‐function mutation. Wild‐type optineurin (OPTNWT) suppresses nuclear factor‐kappa...

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Veröffentlicht in:	Journal of neurochemistry 2013-09, Vol.126 (6), p.699-704
Hauptverfasser:	Akizuki, Mayumi, Yamashita, Hirofumi, Uemura, Kengo, Maruyama, Hirofumi, Kawakami, Hideshi, Ito, Hidefumi, Takahashi, Ryosuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Animals Antineoplastic Agents, Phytogenic - pharmacology Blotting, Western Cell Count Cell Death - genetics Cell Death - physiology Cells, Cultured Coloring Agents Eye Proteins - genetics Genes, p53 - genetics Genes, Reporter Luciferases - genetics Mice Mutation - physiology Neurons - physiology NF-kappa B - antagonists & inhibitors NF-kappa B - genetics NF-kappa B - physiology NF‐κB optineurin Plasmids - genetics Real-Time Polymerase Chain Reaction RNA, Small Interfering - pharmacology Signal Transduction - genetics Signal Transduction - physiology Transfection Trypan Blue Tumor Necrosis Factor-alpha - genetics Withanolides - pharmacology
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