Protocatechuic Acid Induces Angiogenesis through PI3K‐Akt‐eNOS‐VEGF Signalling Pathway

In this study, we sought to elucidate whether protocatechuic acid contributes to induce angiogenesis as well as its mechanisms. To this end, we examined the role of protocatechuic acid on human brain microvascular endothelial cell line (HBMEC) proliferation, invasion and tube formation in in vitro....

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2013-10, Vol.113 (4), p.221-227
Hauptverfasser:	Kang, Zechun, Zhu, Haibo, Jiang, Wanglin, Zhang, Shuping
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Angiogenesis Biological and medical sciences Caspase 3 - genetics Caspase 3 - metabolism Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Chromones - pharmacology Cinnamates - pharmacology Endothelial Cells - drug effects Endothelial Cells - metabolism Enzyme Inhibitors - pharmacology Humans Hydroxybenzoates - pharmacology Medical sciences Morpholines - pharmacology Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Pharmacology. Drug treatments Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Up-Regulation Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-1 - genetics Vascular Endothelial Growth Factor Receptor-1 - metabolism
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