Melatonin attenuates methamphetamine-induced disturbances in mitochondrial dynamics and degeneration in neuroblastoma SH-SY5Y cells

Methamphetamine (METH) is a psychostimulant drug that can cause toxicity and degeneration in the brain. The toxicity due to METH involves multiple pathways, including the mitochondrial‐dependent death pathway. Several pieces of evidence have emphasized that the fragmentation of mitochondria into sma...

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Veröffentlicht in:	Journal of pineal research 2013-10, Vol.55 (3), p.313-323
Hauptverfasser:	Parameyong, Arisa, Charngkaew, Komgrid, Govitrapong, Piyarat, Chetsawang, Banthit
Format:	Artikel
Sprache:	eng
Schlagworte:	Atrophy cell death Cell Death - drug effects Cell Line, Tumor Central Nervous System Depressants - pharmacology Central Nervous System Stimulants - adverse effects Central Nervous System Stimulants - pharmacology GTP Phosphohydrolases - metabolism Humans melatonin Melatonin - pharmacology Membrane Proteins - metabolism methamphetamine Methamphetamine - adverse effects Methamphetamine - pharmacology Microtubule-Associated Proteins - metabolism Mitochondria - metabolism Mitochondria - pathology mitochondrial fission Mitochondrial Membrane Transport Proteins - metabolism Mitochondrial Proteins - metabolism Neoplasm Proteins - metabolism Neuroblastoma - metabolism Neuroblastoma - pathology neurons Neurons - metabolism Neurons - pathology Protein Multimerization - drug effects SH-SY5Y cells
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