Quercetin vs chrysin: Effect on liver histopathology in diabetic mice
Effects of flavonoids quercetin and chrysin on lipid peroxidation and histopathological changes in liver of diabetic mice were studied and compared with the antioxidant and reducing ability of quercetin and chrysin and their ability to chelate Fe2+ ions in vitro. Diabetes was induced in Swiss albino...
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| Veröffentlicht in: | Human & experimental toxicology 2013-10, Vol.32 (10), p.1058-1066 |
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| creator | Sirovina, D. Oršolić, N. Končić, M. Z. Kovačević, G. Benković, V. Gregorović, G. |
| description | Effects of flavonoids quercetin and chrysin on lipid peroxidation and histopathological changes in liver of diabetic mice were studied and compared with the antioxidant and reducing ability of quercetin and chrysin and their ability to chelate Fe2+ ions in vitro. Diabetes was induced in Swiss albino mice with a single intravenous injection of alloxan (75 mg kg−1). Two days after alloxan injection, flavonoid preparations (50 mg kg−1 per day) were given intraperitoneally for 7 days in diabetic mice. The lipid peroxidation was evaluated by measuring the malondialdehyde production using the 2-thiobarbituric acid test. Administration of quercetin and chrysin to diabetic mice resulted in a significant decrease in lipid peroxidation level in liver tissue. Treatment of diabetic mice with flavonoids solutions results in decreased number of vacuolated cells and degree of vacuolization of the liver tissue. The protective role of flavonoids against the reactive oxygen species–induced damages in diabetic mice gives a hope that they may exert similar protective action in humans. |
| doi_str_mv | 10.1177/0960327112472993 |
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Z. ; Kovačević, G. ; Benković, V. ; Gregorović, G.</creator><creatorcontrib>Sirovina, D. ; Oršolić, N. ; Končić, M. Z. ; Kovačević, G. ; Benković, V. ; Gregorović, G.</creatorcontrib><description>Effects of flavonoids quercetin and chrysin on lipid peroxidation and histopathological changes in liver of diabetic mice were studied and compared with the antioxidant and reducing ability of quercetin and chrysin and their ability to chelate Fe2+ ions in vitro. Diabetes was induced in Swiss albino mice with a single intravenous injection of alloxan (75 mg kg−1). Two days after alloxan injection, flavonoid preparations (50 mg kg−1 per day) were given intraperitoneally for 7 days in diabetic mice. The lipid peroxidation was evaluated by measuring the malondialdehyde production using the 2-thiobarbituric acid test. Administration of quercetin and chrysin to diabetic mice resulted in a significant decrease in lipid peroxidation level in liver tissue. Treatment of diabetic mice with flavonoids solutions results in decreased number of vacuolated cells and degree of vacuolization of the liver tissue. The protective role of flavonoids against the reactive oxygen species–induced damages in diabetic mice gives a hope that they may exert similar protective action in humans.</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/0960327112472993</identifier><identifier>PMID: 23357962</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Antioxidants ; Antioxidants - pharmacology ; Biological and medical sciences ; Blood Glucose - analysis ; Diabetes ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - pathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Flavonoids - pharmacology ; Lipid Peroxidation - drug effects ; Lipids ; Liver ; Liver - drug effects ; Liver - pathology ; Male ; Medical sciences ; Mice ; Mice, Inbred CBA ; Oxidative stress ; Quercetin - pharmacology ; Rodents ; Thiobarbituric Acid Reactive Substances - metabolism ; Toxicology</subject><ispartof>Human & experimental toxicology, 2013-10, Vol.32 (10), p.1058-1066</ispartof><rights>The Author(s) 2013</rights><rights>2015 INIST-CNRS</rights><rights>SAGE Publications © Oct 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c381t-80b62001b49198759978d6daffe05c9b3d8af5ce4e5db225bf53a3aaab4f1fe53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0960327112472993$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0960327112472993$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,782,786,21973,27860,27931,27932,44952,45340</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/0960327112472993?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28541741$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23357962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sirovina, D.</creatorcontrib><creatorcontrib>Oršolić, N.</creatorcontrib><creatorcontrib>Končić, M. Z.</creatorcontrib><creatorcontrib>Kovačević, G.</creatorcontrib><creatorcontrib>Benković, V.</creatorcontrib><creatorcontrib>Gregorović, G.</creatorcontrib><title>Quercetin vs chrysin: Effect on liver histopathology in diabetic mice</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>Effects of flavonoids quercetin and chrysin on lipid peroxidation and histopathological changes in liver of diabetic mice were studied and compared with the antioxidant and reducing ability of quercetin and chrysin and their ability to chelate Fe2+ ions in vitro. Diabetes was induced in Swiss albino mice with a single intravenous injection of alloxan (75 mg kg−1). Two days after alloxan injection, flavonoid preparations (50 mg kg−1 per day) were given intraperitoneally for 7 days in diabetic mice. The lipid peroxidation was evaluated by measuring the malondialdehyde production using the 2-thiobarbituric acid test. Administration of quercetin and chrysin to diabetic mice resulted in a significant decrease in lipid peroxidation level in liver tissue. Treatment of diabetic mice with flavonoids solutions results in decreased number of vacuolated cells and degree of vacuolization of the liver tissue. The protective role of flavonoids against the reactive oxygen species–induced damages in diabetic mice gives a hope that they may exert similar protective action in humans.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. 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Target tissue resistance</subject><subject>Flavonoids - pharmacology</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipids</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Oxidative stress</subject><subject>Quercetin - pharmacology</subject><subject>Rodents</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Toxicology</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp10MtLAzEQBvAgiq3VmwdPUhDBy-pMHpvNsRRfUBBBz0s2m-iW7W5NukL_e7O0Pih4ymF-M_n4CDlDuEaU8gZUCoxKRMolVYrtkSFyKRNQwPbJsB8n_XxAjkKYA0CqBB6SAWVMSJXSITl97qw3dlU1488wNu9-HarmmBw4XQd7sn1H5PXu9mX6kMye7h-nk1liWIarJIMipQBYcIUqk0IpmZVpqZ2zIIwqWJlpJ4zlVpQFpaJwgmmmtS64Q2cFG5Grzd2lbz86G1b5ogrG1rVubNuFHLnIBEcUEOnFDp23nW9iuqg4B0w5o1HBRhnfhuCty5e-Wmi_zhHyvrF8t7G4cr493BULW_4sfFcUweUW6GB07bxuTBV-XZ9Qcowu2big3-yfdP99_AWhtXy6</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Sirovina, D.</creator><creator>Oršolić, N.</creator><creator>Končić, M. 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Z. ; Kovačević, G. ; Benković, V. ; Gregorović, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-80b62001b49198759978d6daffe05c9b3d8af5ce4e5db225bf53a3aaab4f1fe53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - pathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Flavonoids - pharmacology</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipids</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Oxidative stress</topic><topic>Quercetin - pharmacology</topic><topic>Rodents</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sirovina, D.</creatorcontrib><creatorcontrib>Oršolić, N.</creatorcontrib><creatorcontrib>Končić, M. 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Z.</au><au>Kovačević, G.</au><au>Benković, V.</au><au>Gregorović, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quercetin vs chrysin: Effect on liver histopathology in diabetic mice</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>32</volume><issue>10</issue><spage>1058</spage><epage>1066</epage><pages>1058-1066</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>Effects of flavonoids quercetin and chrysin on lipid peroxidation and histopathological changes in liver of diabetic mice were studied and compared with the antioxidant and reducing ability of quercetin and chrysin and their ability to chelate Fe2+ ions in vitro. Diabetes was induced in Swiss albino mice with a single intravenous injection of alloxan (75 mg kg−1). Two days after alloxan injection, flavonoid preparations (50 mg kg−1 per day) were given intraperitoneally for 7 days in diabetic mice. The lipid peroxidation was evaluated by measuring the malondialdehyde production using the 2-thiobarbituric acid test. Administration of quercetin and chrysin to diabetic mice resulted in a significant decrease in lipid peroxidation level in liver tissue. Treatment of diabetic mice with flavonoids solutions results in decreased number of vacuolated cells and degree of vacuolization of the liver tissue. The protective role of flavonoids against the reactive oxygen species–induced damages in diabetic mice gives a hope that they may exert similar protective action in humans.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>23357962</pmid><doi>10.1177/0960327112472993</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Antioxidants Antioxidants - pharmacology Biological and medical sciences Blood Glucose - analysis Diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - pathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Flavonoids - pharmacology Lipid Peroxidation - drug effects Lipids Liver Liver - drug effects Liver - pathology Male Medical sciences Mice Mice, Inbred CBA Oxidative stress Quercetin - pharmacology Rodents Thiobarbituric Acid Reactive Substances - metabolism Toxicology |
| title | Quercetin vs chrysin: Effect on liver histopathology in diabetic mice |
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