The role of adjuvant radiotherapy in atypical meningioma
The object of this study was to analyze treatment outcomes and to identify the prognostic factors, with a focus on the role of adjuvant radiotherapy (ART), predicting disease progression in atypical meningiomas. From 1997 to 2011, 83 patients with meningioma were included in this study. All patients...
Gespeichert in:
| Veröffentlicht in: | Journal of neuro-oncology 2013-11, Vol.115 (2), p.241-247 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 247 |
|---|---|
| container_issue | 2 |
| container_start_page | 241 |
| container_title | Journal of neuro-oncology |
| container_volume | 115 |
| creator | Park, Hae Jin Kang, Hyun-Cheol Kim, Il Han Park, Sung-Hye Kim, Dong Gyu Park, Chul-Kee Paek, Sun Ha Jung, Hee-Won |
| description | The object of this study was to analyze treatment outcomes and to identify the prognostic factors, with a focus on the role of adjuvant radiotherapy (ART), predicting disease progression in atypical meningiomas. From 1997 to 2011, 83 patients with meningioma were included in this study. All patients were histologically confirmed as atypical meningioma and were treated with surgical resection with or without ART. As primary therapy, 27 patients received surgical resection followed by ART, and 56 received no adjuvant therapy. Of 83 evaluable patients, 55 (66.3 %) patients underwent complete resection. The median ART dose was 61.2 Gy and their median age was 52 years. The 5- and 10-year actuarial overall survival rates were 90.2 and 62.0 %, and the 5- and 10-year progression-free survival (PFS) rates were both 48.0 %, with a median follow-up of 43.0 months. Addition of ART (
p
= 0.016) and complete tumor resection (
p
= 0.002) were associated with superior PFS. When stratified to four groups according to resection status and ART, the groups of patient with incomplete resection without ART showed significantly worse PFS compared to other three groups (
p
|
| doi_str_mv | 10.1007/s11060-013-1219-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1458541085</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3102731041</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-68da91d031abdf1693fe73e97f4d328b5bdb38a15408b37881c5ff7c8b7389ba3</originalsourceid><addsrcrecordid>eNqNkUtLxDAUhYMozjj6A9xIwY2baG6TNMlSBl8guBnBXUjadKZDH2PSCv33tnQUEQRXd3G_cy7nHoTOgVwDIeImAJCEYAIUQwwK9wdoDlxQLKigh2hOIBGYK_Y2QychbAkhTFA4RrOYKqaAyDmSq42LfFO6qMkjk227D1O3kTdZ0bQb582uj4o6Mm2_K1JTRpWri3pdNJU5RUe5KYM7288Fer2_Wy0f8fPLw9Py9hmnTECLE5kZBRmhYGyWQ6Jo7gR1SuQso7G03GaWSgOcEWmpkBJSnucilVZQqayhC3Q1-e5889650OqqCKkrS1O7pgsaGJecDVn4P1BGlRIJG9HLX-i26Xw9BBmpWMWSKTFQMFGpb0LwLtc7X1TG9xqIHhvQUwN6aECPDeh-0FzsnTtbuexb8fXyAYgnIAyreu38j9N_un4CUNWPpQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1442928497</pqid></control><display><type>article</type><title>The role of adjuvant radiotherapy in atypical meningioma</title><source>MEDLINE</source><source>SpringerLink</source><creator>Park, Hae Jin ; Kang, Hyun-Cheol ; Kim, Il Han ; Park, Sung-Hye ; Kim, Dong Gyu ; Park, Chul-Kee ; Paek, Sun Ha ; Jung, Hee-Won</creator><creatorcontrib>Park, Hae Jin ; Kang, Hyun-Cheol ; Kim, Il Han ; Park, Sung-Hye ; Kim, Dong Gyu ; Park, Chul-Kee ; Paek, Sun Ha ; Jung, Hee-Won</creatorcontrib><description>The object of this study was to analyze treatment outcomes and to identify the prognostic factors, with a focus on the role of adjuvant radiotherapy (ART), predicting disease progression in atypical meningiomas. From 1997 to 2011, 83 patients with meningioma were included in this study. All patients were histologically confirmed as atypical meningioma and were treated with surgical resection with or without ART. As primary therapy, 27 patients received surgical resection followed by ART, and 56 received no adjuvant therapy. Of 83 evaluable patients, 55 (66.3 %) patients underwent complete resection. The median ART dose was 61.2 Gy and their median age was 52 years. The 5- and 10-year actuarial overall survival rates were 90.2 and 62.0 %, and the 5- and 10-year progression-free survival (PFS) rates were both 48.0 %, with a median follow-up of 43.0 months. Addition of ART (
p
= 0.016) and complete tumor resection (
p
= 0.002) were associated with superior PFS. When stratified to four groups according to resection status and ART, the groups of patient with incomplete resection without ART showed significantly worse PFS compared to other three groups (
p
< 0.001). In conclusion, surgical resection followed by ART led to lower local tumor progression in patients with atypical meningioma defined by the updated 2000/2007 WHO classification. Our results may contribute to the routine use of ART, especially after incomplete resection, until the outcomes of ongoing prospective trials are available.</description><identifier>ISSN: 0167-594X</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1007/s11060-013-1219-y</identifier><identifier>PMID: 23949108</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Aged ; Clinical Study ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Male ; Medicine ; Medicine & Public Health ; Meningeal Neoplasms - mortality ; Meningeal Neoplasms - pathology ; Meningeal Neoplasms - radiotherapy ; Meningioma - mortality ; Meningioma - pathology ; Meningioma - radiotherapy ; Middle Aged ; Neoplasm Grading ; Neurology ; Oncology ; Radiotherapy, Adjuvant ; Retrospective Studies ; Survival Rate ; Treatment Outcome</subject><ispartof>Journal of neuro-oncology, 2013-11, Vol.115 (2), p.241-247</ispartof><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-68da91d031abdf1693fe73e97f4d328b5bdb38a15408b37881c5ff7c8b7389ba3</citedby><cites>FETCH-LOGICAL-c471t-68da91d031abdf1693fe73e97f4d328b5bdb38a15408b37881c5ff7c8b7389ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11060-013-1219-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11060-013-1219-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23949108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Hae Jin</creatorcontrib><creatorcontrib>Kang, Hyun-Cheol</creatorcontrib><creatorcontrib>Kim, Il Han</creatorcontrib><creatorcontrib>Park, Sung-Hye</creatorcontrib><creatorcontrib>Kim, Dong Gyu</creatorcontrib><creatorcontrib>Park, Chul-Kee</creatorcontrib><creatorcontrib>Paek, Sun Ha</creatorcontrib><creatorcontrib>Jung, Hee-Won</creatorcontrib><title>The role of adjuvant radiotherapy in atypical meningioma</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><addtitle>J Neurooncol</addtitle><description>The object of this study was to analyze treatment outcomes and to identify the prognostic factors, with a focus on the role of adjuvant radiotherapy (ART), predicting disease progression in atypical meningiomas. From 1997 to 2011, 83 patients with meningioma were included in this study. All patients were histologically confirmed as atypical meningioma and were treated with surgical resection with or without ART. As primary therapy, 27 patients received surgical resection followed by ART, and 56 received no adjuvant therapy. Of 83 evaluable patients, 55 (66.3 %) patients underwent complete resection. The median ART dose was 61.2 Gy and their median age was 52 years. The 5- and 10-year actuarial overall survival rates were 90.2 and 62.0 %, and the 5- and 10-year progression-free survival (PFS) rates were both 48.0 %, with a median follow-up of 43.0 months. Addition of ART (
p
= 0.016) and complete tumor resection (
p
= 0.002) were associated with superior PFS. When stratified to four groups according to resection status and ART, the groups of patient with incomplete resection without ART showed significantly worse PFS compared to other three groups (
p
< 0.001). In conclusion, surgical resection followed by ART led to lower local tumor progression in patients with atypical meningioma defined by the updated 2000/2007 WHO classification. Our results may contribute to the routine use of ART, especially after incomplete resection, until the outcomes of ongoing prospective trials are available.</description><subject>Adult</subject><subject>Aged</subject><subject>Clinical Study</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meningeal Neoplasms - mortality</subject><subject>Meningeal Neoplasms - pathology</subject><subject>Meningeal Neoplasms - radiotherapy</subject><subject>Meningioma - mortality</subject><subject>Meningioma - pathology</subject><subject>Meningioma - radiotherapy</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neurology</subject><subject>Oncology</subject><subject>Radiotherapy, Adjuvant</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>0167-594X</issn><issn>1573-7373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkUtLxDAUhYMozjj6A9xIwY2baG6TNMlSBl8guBnBXUjadKZDH2PSCv33tnQUEQRXd3G_cy7nHoTOgVwDIeImAJCEYAIUQwwK9wdoDlxQLKigh2hOIBGYK_Y2QychbAkhTFA4RrOYKqaAyDmSq42LfFO6qMkjk227D1O3kTdZ0bQb582uj4o6Mm2_K1JTRpWri3pdNJU5RUe5KYM7288Fer2_Wy0f8fPLw9Py9hmnTECLE5kZBRmhYGyWQ6Jo7gR1SuQso7G03GaWSgOcEWmpkBJSnucilVZQqayhC3Q1-e5889650OqqCKkrS1O7pgsaGJecDVn4P1BGlRIJG9HLX-i26Xw9BBmpWMWSKTFQMFGpb0LwLtc7X1TG9xqIHhvQUwN6aECPDeh-0FzsnTtbuexb8fXyAYgnIAyreu38j9N_un4CUNWPpQ</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Park, Hae Jin</creator><creator>Kang, Hyun-Cheol</creator><creator>Kim, Il Han</creator><creator>Park, Sung-Hye</creator><creator>Kim, Dong Gyu</creator><creator>Park, Chul-Kee</creator><creator>Paek, Sun Ha</creator><creator>Jung, Hee-Won</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20131101</creationdate><title>The role of adjuvant radiotherapy in atypical meningioma</title><author>Park, Hae Jin ; Kang, Hyun-Cheol ; Kim, Il Han ; Park, Sung-Hye ; Kim, Dong Gyu ; Park, Chul-Kee ; Paek, Sun Ha ; Jung, Hee-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-68da91d031abdf1693fe73e97f4d328b5bdb38a15408b37881c5ff7c8b7389ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Clinical Study</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meningeal Neoplasms - mortality</topic><topic>Meningeal Neoplasms - pathology</topic><topic>Meningeal Neoplasms - radiotherapy</topic><topic>Meningioma - mortality</topic><topic>Meningioma - pathology</topic><topic>Meningioma - radiotherapy</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neurology</topic><topic>Oncology</topic><topic>Radiotherapy, Adjuvant</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Hae Jin</creatorcontrib><creatorcontrib>Kang, Hyun-Cheol</creatorcontrib><creatorcontrib>Kim, Il Han</creatorcontrib><creatorcontrib>Park, Sung-Hye</creatorcontrib><creatorcontrib>Kim, Dong Gyu</creatorcontrib><creatorcontrib>Park, Chul-Kee</creatorcontrib><creatorcontrib>Paek, Sun Ha</creatorcontrib><creatorcontrib>Jung, Hee-Won</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuro-oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Hae Jin</au><au>Kang, Hyun-Cheol</au><au>Kim, Il Han</au><au>Park, Sung-Hye</au><au>Kim, Dong Gyu</au><au>Park, Chul-Kee</au><au>Paek, Sun Ha</au><au>Jung, Hee-Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of adjuvant radiotherapy in atypical meningioma</atitle><jtitle>Journal of neuro-oncology</jtitle><stitle>J Neurooncol</stitle><addtitle>J Neurooncol</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>115</volume><issue>2</issue><spage>241</spage><epage>247</epage><pages>241-247</pages><issn>0167-594X</issn><eissn>1573-7373</eissn><abstract>The object of this study was to analyze treatment outcomes and to identify the prognostic factors, with a focus on the role of adjuvant radiotherapy (ART), predicting disease progression in atypical meningiomas. From 1997 to 2011, 83 patients with meningioma were included in this study. All patients were histologically confirmed as atypical meningioma and were treated with surgical resection with or without ART. As primary therapy, 27 patients received surgical resection followed by ART, and 56 received no adjuvant therapy. Of 83 evaluable patients, 55 (66.3 %) patients underwent complete resection. The median ART dose was 61.2 Gy and their median age was 52 years. The 5- and 10-year actuarial overall survival rates were 90.2 and 62.0 %, and the 5- and 10-year progression-free survival (PFS) rates were both 48.0 %, with a median follow-up of 43.0 months. Addition of ART (
p
= 0.016) and complete tumor resection (
p
= 0.002) were associated with superior PFS. When stratified to four groups according to resection status and ART, the groups of patient with incomplete resection without ART showed significantly worse PFS compared to other three groups (
p
< 0.001). In conclusion, surgical resection followed by ART led to lower local tumor progression in patients with atypical meningioma defined by the updated 2000/2007 WHO classification. Our results may contribute to the routine use of ART, especially after incomplete resection, until the outcomes of ongoing prospective trials are available.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23949108</pmid><doi>10.1007/s11060-013-1219-y</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-594X |
| ispartof | Journal of neuro-oncology, 2013-11, Vol.115 (2), p.241-247 |
| issn | 0167-594X 1573-7373 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1458541085 |
| source | MEDLINE; SpringerLink |
| subjects | Adult Aged Clinical Study Disease Progression Female Follow-Up Studies Humans Male Medicine Medicine & Public Health Meningeal Neoplasms - mortality Meningeal Neoplasms - pathology Meningeal Neoplasms - radiotherapy Meningioma - mortality Meningioma - pathology Meningioma - radiotherapy Middle Aged Neoplasm Grading Neurology Oncology Radiotherapy, Adjuvant Retrospective Studies Survival Rate Treatment Outcome |
| title | The role of adjuvant radiotherapy in atypical meningioma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T17%3A50%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20adjuvant%20radiotherapy%20in%20atypical%20meningioma&rft.jtitle=Journal%20of%20neuro-oncology&rft.au=Park,%20Hae%20Jin&rft.date=2013-11-01&rft.volume=115&rft.issue=2&rft.spage=241&rft.epage=247&rft.pages=241-247&rft.issn=0167-594X&rft.eissn=1573-7373&rft_id=info:doi/10.1007/s11060-013-1219-y&rft_dat=%3Cproquest_cross%3E3102731041%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1442928497&rft_id=info:pmid/23949108&rfr_iscdi=true |