Synthesis and Cytotoxic Evaluation of Acylated Brefeldin A Derivatives as Potential Anticancer Agents
Brefeldin A has attracted considerable attention because of its potential function in cancer prevention. However, its therapeutic use is limited by its poor bioavailability. The modifications on brefeldin A were difficult because of its low stability and selectivity toward two hydroxyl groups within...
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Veröffentlicht in: | Chemical biology & drug design 2013-09, Vol.82 (3), p.307-316 |
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Sprache: | eng |
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