Synthesis and Cytotoxic Evaluation of Acylated Brefeldin A Derivatives as Potential Anticancer Agents

Brefeldin A has attracted considerable attention because of its potential function in cancer prevention. However, its therapeutic use is limited by its poor bioavailability. The modifications on brefeldin A were difficult because of its low stability and selectivity toward two hydroxyl groups within...

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Veröffentlicht in:Chemical biology & drug design 2013-09, Vol.82 (3), p.307-316
Hauptverfasser: He, Bingyong, Wang, Yajun, Zheng, Yuguo, Chen, Wei, Zhu, Qing
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Sprache:eng
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