Comorbidity burden in patients with chronic GVHD
Chronic GVHD (cGVHD) is associated with mortality, disability and impaired quality of life. Understanding the role of comorbidity in patients with cGVHD is important both for prognostication and potentially for tailoring treatments based on mortality risks. In a prospective cohort study of patients...
Gespeichert in:
| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2013-11, Vol.48 (11), p.1429-1436 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1436 |
|---|---|
| container_issue | 11 |
| container_start_page | 1429 |
| container_title | Bone marrow transplantation (Basingstoke) |
| container_volume | 48 |
| creator | Wood, W A Chai, X Weisdorf, D Martin, P J Cutler, C Inamoto, Y Wolff, D Pavletic, S Z Pidala, J Palmer, J M Arora, M Arai, S Jagasia, M Storer, B Lee, S J Mitchell, S |
| description | Chronic GVHD (cGVHD) is associated with mortality, disability and impaired quality of life. Understanding the role of comorbidity in patients with cGVHD is important both for prognostication and potentially for tailoring treatments based on mortality risks. In a prospective cohort study of patients with cGVHD (
n
=239), we examined the performance of two comorbidity scales, the Functional Comorbidity Index (FCI) and the Hematopoietic Cell Transplantation-specific Comorbidity Index (HCT-CI). Both scales detected a higher number of comorbidities at cGVHD cohort enrollment than pre-hematopoietic cell transplant (HCT) (
P
100 000/μL (HR: 1.05:0.90–1.22,
P
=0.53). Comorbidity scoring may help better to predict survival outcomes in patients with cGVHD. Further studies to understand vulnerability unrelated to cGVHD activity in this patient population are needed. |
| doi_str_mv | 10.1038/bmt.2013.70 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1458539444</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A352040392</galeid><sourcerecordid>A352040392</sourcerecordid><originalsourceid>FETCH-LOGICAL-c606t-a0e02622d25056eb077f43c0d1047e6156f55a9ba7d6532fad905d3ab87d06e03</originalsourceid><addsrcrecordid>eNqN0t1rFDEQAPBFFHutPvkuC6IIuufkczeP5aqtUPBFfQ3ZJNtL2U3OJIv0vzfLnbaVIpKHQPKbGWaYqnqBYI2AdB_6Ka8xILJu4VG1QrTlDSOcPa5WgHnXEMLFUXWc0jUAohTY0-oIE85Zh8Sqgk2YQuydcfmm7udorK-dr3cqO-tzqn-6vK31NgbvdH3-_eLsWfVkUGOyzw_3SfXt08evm4vm8sv5583pZaM58NwosKU6xgYzYNz20LYDJRoMAtpajhgfGFOiV63hjOBBGQHMENV3rQFugZxUb_d5dzH8mG3KcnJJ23FU3oY5SURZx4iglP4HpQJ3wPBCX_1Fr8McfWlEYk4xagmH7l-q5OpawQRCt-pKjVY6P4QclV5Ky1PCMFAgAhe1fkCVY-zkdPB2cOX9XsCbOwFbq8a8TWGcsws-3Yfv9lDHkFK0g9xFN6l4IxHIZTNk2Qy5bIZsl3m-PPQ095M1f-zvVSjg9QGopNU4ROW1S7du6VoIXtz7vUvly1_ZeGc4D9T9BYbeyEA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1448795911</pqid></control><display><type>article</type><title>Comorbidity burden in patients with chronic GVHD</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Wood, W A ; Chai, X ; Weisdorf, D ; Martin, P J ; Cutler, C ; Inamoto, Y ; Wolff, D ; Pavletic, S Z ; Pidala, J ; Palmer, J M ; Arora, M ; Arai, S ; Jagasia, M ; Storer, B ; Lee, S J ; Mitchell, S</creator><creatorcontrib>Wood, W A ; Chai, X ; Weisdorf, D ; Martin, P J ; Cutler, C ; Inamoto, Y ; Wolff, D ; Pavletic, S Z ; Pidala, J ; Palmer, J M ; Arora, M ; Arai, S ; Jagasia, M ; Storer, B ; Lee, S J ; Mitchell, S</creatorcontrib><description>Chronic GVHD (cGVHD) is associated with mortality, disability and impaired quality of life. Understanding the role of comorbidity in patients with cGVHD is important both for prognostication and potentially for tailoring treatments based on mortality risks. In a prospective cohort study of patients with cGVHD (
n
=239), we examined the performance of two comorbidity scales, the Functional Comorbidity Index (FCI) and the Hematopoietic Cell Transplantation-specific Comorbidity Index (HCT-CI). Both scales detected a higher number of comorbidities at cGVHD cohort enrollment than pre-hematopoietic cell transplant (HCT) (
P
<0.001). Higher HCT-CI scores at the time of cGVHD cohort enrollment were associated with higher non-relapse mortality (HR: 1.21:1.04–1.42,
P
=0.01). For overall mortality, we detected an interaction with platelet count. Higher HCT-CI scores at enrollment were associated with an increased risk of overall mortality when the platelet count was ⩽100 000/μL (HR: 2.01:1.20–3.35,
P
=0.01), but not when it was >100 000/μL (HR: 1.05:0.90–1.22,
P
=0.53). Comorbidity scoring may help better to predict survival outcomes in patients with cGVHD. Further studies to understand vulnerability unrelated to cGVHD activity in this patient population are needed.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/bmt.2013.70</identifier><identifier>PMID: 23665819</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/1904 ; 692/699/249/1529 ; 692/700/784 ; Adolescent ; Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone marrow ; Bone marrow transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Cell Biology ; Child ; Child, Preschool ; Chronic Disease ; Comorbidity ; Comparative analysis ; Female ; Graft versus host reaction ; Graft vs Host Disease - pathology ; Hematology ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic Stem Cell Transplantation - methods ; Hematopoietic stem cells ; Humans ; Internal Medicine ; Male ; Medical care ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; original-article ; Physiological aspects ; Platelets ; Prospective Studies ; Public Health ; Quality of life ; Stem cell transplantation ; Stem Cells ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Transplantation Conditioning - methods ; Transplants & implants ; Treatment Outcome ; Young Adult</subject><ispartof>Bone marrow transplantation (Basingstoke), 2013-11, Vol.48 (11), p.1429-1436</ispartof><rights>Macmillan Publishers Limited 2013</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2013 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2013</rights><rights>Macmillan Publishers Limited 2013.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c606t-a0e02622d25056eb077f43c0d1047e6156f55a9ba7d6532fad905d3ab87d06e03</citedby><cites>FETCH-LOGICAL-c606t-a0e02622d25056eb077f43c0d1047e6156f55a9ba7d6532fad905d3ab87d06e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/bmt.2013.70$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/bmt.2013.70$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27959996$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23665819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wood, W A</creatorcontrib><creatorcontrib>Chai, X</creatorcontrib><creatorcontrib>Weisdorf, D</creatorcontrib><creatorcontrib>Martin, P J</creatorcontrib><creatorcontrib>Cutler, C</creatorcontrib><creatorcontrib>Inamoto, Y</creatorcontrib><creatorcontrib>Wolff, D</creatorcontrib><creatorcontrib>Pavletic, S Z</creatorcontrib><creatorcontrib>Pidala, J</creatorcontrib><creatorcontrib>Palmer, J M</creatorcontrib><creatorcontrib>Arora, M</creatorcontrib><creatorcontrib>Arai, S</creatorcontrib><creatorcontrib>Jagasia, M</creatorcontrib><creatorcontrib>Storer, B</creatorcontrib><creatorcontrib>Lee, S J</creatorcontrib><creatorcontrib>Mitchell, S</creatorcontrib><title>Comorbidity burden in patients with chronic GVHD</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><addtitle>Bone Marrow Transplant</addtitle><description>Chronic GVHD (cGVHD) is associated with mortality, disability and impaired quality of life. Understanding the role of comorbidity in patients with cGVHD is important both for prognostication and potentially for tailoring treatments based on mortality risks. In a prospective cohort study of patients with cGVHD (
n
=239), we examined the performance of two comorbidity scales, the Functional Comorbidity Index (FCI) and the Hematopoietic Cell Transplantation-specific Comorbidity Index (HCT-CI). Both scales detected a higher number of comorbidities at cGVHD cohort enrollment than pre-hematopoietic cell transplant (HCT) (
P
<0.001). Higher HCT-CI scores at the time of cGVHD cohort enrollment were associated with higher non-relapse mortality (HR: 1.21:1.04–1.42,
P
=0.01). For overall mortality, we detected an interaction with platelet count. Higher HCT-CI scores at enrollment were associated with an increased risk of overall mortality when the platelet count was ⩽100 000/μL (HR: 2.01:1.20–3.35,
P
=0.01), but not when it was >100 000/μL (HR: 1.05:0.90–1.22,
P
=0.53). Comorbidity scoring may help better to predict survival outcomes in patients with cGVHD. Further studies to understand vulnerability unrelated to cGVHD activity in this patient population are needed.</description><subject>631/250/1904</subject><subject>692/699/249/1529</subject><subject>692/700/784</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone marrow transplantation</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Cell Biology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chronic Disease</subject><subject>Comorbidity</subject><subject>Comparative analysis</subject><subject>Female</subject><subject>Graft versus host reaction</subject><subject>Graft vs Host Disease - pathology</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic Stem Cell Transplantation - methods</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical care</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Platelets</subject><subject>Prospective Studies</subject><subject>Public Health</subject><subject>Quality of life</subject><subject>Stem cell transplantation</subject><subject>Stem Cells</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Transplantation</subject><subject>Transplantation Conditioning - methods</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0268-3369</issn><issn>1476-5365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqN0t1rFDEQAPBFFHutPvkuC6IIuufkczeP5aqtUPBFfQ3ZJNtL2U3OJIv0vzfLnbaVIpKHQPKbGWaYqnqBYI2AdB_6Ka8xILJu4VG1QrTlDSOcPa5WgHnXEMLFUXWc0jUAohTY0-oIE85Zh8Sqgk2YQuydcfmm7udorK-dr3cqO-tzqn-6vK31NgbvdH3-_eLsWfVkUGOyzw_3SfXt08evm4vm8sv5583pZaM58NwosKU6xgYzYNz20LYDJRoMAtpajhgfGFOiV63hjOBBGQHMENV3rQFugZxUb_d5dzH8mG3KcnJJ23FU3oY5SURZx4iglP4HpQJ3wPBCX_1Fr8McfWlEYk4xagmH7l-q5OpawQRCt-pKjVY6P4QclV5Ky1PCMFAgAhe1fkCVY-zkdPB2cOX9XsCbOwFbq8a8TWGcsws-3Yfv9lDHkFK0g9xFN6l4IxHIZTNk2Qy5bIZsl3m-PPQ095M1f-zvVSjg9QGopNU4ROW1S7du6VoIXtz7vUvly1_ZeGc4D9T9BYbeyEA</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Wood, W A</creator><creator>Chai, X</creator><creator>Weisdorf, D</creator><creator>Martin, P J</creator><creator>Cutler, C</creator><creator>Inamoto, Y</creator><creator>Wolff, D</creator><creator>Pavletic, S Z</creator><creator>Pidala, J</creator><creator>Palmer, J M</creator><creator>Arora, M</creator><creator>Arai, S</creator><creator>Jagasia, M</creator><creator>Storer, B</creator><creator>Lee, S J</creator><creator>Mitchell, S</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20131101</creationdate><title>Comorbidity burden in patients with chronic GVHD</title><author>Wood, W A ; Chai, X ; Weisdorf, D ; Martin, P J ; Cutler, C ; Inamoto, Y ; Wolff, D ; Pavletic, S Z ; Pidala, J ; Palmer, J M ; Arora, M ; Arai, S ; Jagasia, M ; Storer, B ; Lee, S J ; Mitchell, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c606t-a0e02622d25056eb077f43c0d1047e6156f55a9ba7d6532fad905d3ab87d06e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>631/250/1904</topic><topic>692/699/249/1529</topic><topic>692/700/784</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Bone marrow transplantation</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Cell Biology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chronic Disease</topic><topic>Comorbidity</topic><topic>Comparative analysis</topic><topic>Female</topic><topic>Graft versus host reaction</topic><topic>Graft vs Host Disease - pathology</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hematopoietic Stem Cell Transplantation - methods</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical care</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>original-article</topic><topic>Physiological aspects</topic><topic>Platelets</topic><topic>Prospective Studies</topic><topic>Public Health</topic><topic>Quality of life</topic><topic>Stem cell transplantation</topic><topic>Stem Cells</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Transplantation</topic><topic>Transplantation Conditioning - methods</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wood, W A</creatorcontrib><creatorcontrib>Chai, X</creatorcontrib><creatorcontrib>Weisdorf, D</creatorcontrib><creatorcontrib>Martin, P J</creatorcontrib><creatorcontrib>Cutler, C</creatorcontrib><creatorcontrib>Inamoto, Y</creatorcontrib><creatorcontrib>Wolff, D</creatorcontrib><creatorcontrib>Pavletic, S Z</creatorcontrib><creatorcontrib>Pidala, J</creatorcontrib><creatorcontrib>Palmer, J M</creatorcontrib><creatorcontrib>Arora, M</creatorcontrib><creatorcontrib>Arai, S</creatorcontrib><creatorcontrib>Jagasia, M</creatorcontrib><creatorcontrib>Storer, B</creatorcontrib><creatorcontrib>Lee, S J</creatorcontrib><creatorcontrib>Mitchell, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Bone marrow transplantation (Basingstoke)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wood, W A</au><au>Chai, X</au><au>Weisdorf, D</au><au>Martin, P J</au><au>Cutler, C</au><au>Inamoto, Y</au><au>Wolff, D</au><au>Pavletic, S Z</au><au>Pidala, J</au><au>Palmer, J M</au><au>Arora, M</au><au>Arai, S</au><au>Jagasia, M</au><au>Storer, B</au><au>Lee, S J</au><au>Mitchell, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comorbidity burden in patients with chronic GVHD</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><stitle>Bone Marrow Transplant</stitle><addtitle>Bone Marrow Transplant</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>48</volume><issue>11</issue><spage>1429</spage><epage>1436</epage><pages>1429-1436</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><coden>BMTRE9</coden><abstract>Chronic GVHD (cGVHD) is associated with mortality, disability and impaired quality of life. Understanding the role of comorbidity in patients with cGVHD is important both for prognostication and potentially for tailoring treatments based on mortality risks. In a prospective cohort study of patients with cGVHD (
n
=239), we examined the performance of two comorbidity scales, the Functional Comorbidity Index (FCI) and the Hematopoietic Cell Transplantation-specific Comorbidity Index (HCT-CI). Both scales detected a higher number of comorbidities at cGVHD cohort enrollment than pre-hematopoietic cell transplant (HCT) (
P
<0.001). Higher HCT-CI scores at the time of cGVHD cohort enrollment were associated with higher non-relapse mortality (HR: 1.21:1.04–1.42,
P
=0.01). For overall mortality, we detected an interaction with platelet count. Higher HCT-CI scores at enrollment were associated with an increased risk of overall mortality when the platelet count was ⩽100 000/μL (HR: 2.01:1.20–3.35,
P
=0.01), but not when it was >100 000/μL (HR: 1.05:0.90–1.22,
P
=0.53). Comorbidity scoring may help better to predict survival outcomes in patients with cGVHD. Further studies to understand vulnerability unrelated to cGVHD activity in this patient population are needed.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23665819</pmid><doi>10.1038/bmt.2013.70</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2013-11, Vol.48 (11), p.1429-1436 |
| issn | 0268-3369 1476-5365 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1458539444 |
| source | MEDLINE; SpringerLink Journals; Nature; EZB-FREE-00999 freely available EZB journals |
| subjects | 631/250/1904 692/699/249/1529 692/700/784 Adolescent Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow Bone marrow transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Cell Biology Child Child, Preschool Chronic Disease Comorbidity Comparative analysis Female Graft versus host reaction Graft vs Host Disease - pathology Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Humans Internal Medicine Male Medical care Medical sciences Medicine Medicine & Public Health Middle Aged Mortality original-article Physiological aspects Platelets Prospective Studies Public Health Quality of life Stem cell transplantation Stem Cells Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Conditioning - methods Transplants & implants Treatment Outcome Young Adult |
| title | Comorbidity burden in patients with chronic GVHD |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T04%3A11%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comorbidity%20burden%20in%20patients%20with%20chronic%20GVHD&rft.jtitle=Bone%20marrow%20transplantation%20(Basingstoke)&rft.au=Wood,%20W%20A&rft.date=2013-11-01&rft.volume=48&rft.issue=11&rft.spage=1429&rft.epage=1436&rft.pages=1429-1436&rft.issn=0268-3369&rft.eissn=1476-5365&rft.coden=BMTRE9&rft_id=info:doi/10.1038/bmt.2013.70&rft_dat=%3Cgale_proqu%3EA352040392%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1448795911&rft_id=info:pmid/23665819&rft_galeid=A352040392&rfr_iscdi=true |