Population pharmacokinetic analysis of blood concentrations of robenacoxib in dogs with osteoarthritis

The purpose of this analysis was to investigate whether the recommended daily dosage of 1–2mg/kg robenacoxib provides consistent exposure when administered to dogs with chronic osteoarthritis (OA), and the need for dose adjustment in special patient populations. Data from three prospective, multi-ce...

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Veröffentlicht in:	Research in veterinary science 2013-10, Vol.95 (2), p.580-587
Hauptverfasser:	Fink, M., Letellier, I., Peyrou, M., Mochel, J.P., Jung, M., King, J.N., Gruet, P., Giraudel, J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Blood Body Weight Chronic Disease COXIB Diphenylamine - analogs & derivatives Diphenylamine - blood Diphenylamine - pharmacokinetics Dog Dog Diseases - blood Dog Diseases - drug therapy Dogs Female hematologic tests kidneys liver Male osteoarthritis Osteoarthritis - blood Osteoarthritis - drug therapy Osteoarthritis - veterinary patients pharmacokinetics Phenylacetates - blood Phenylacetates - pharmacokinetics population characteristics Population pharmacokinetics Robenacoxib Sex Factors Veterinary medicine
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