Laminar shear stress upregulates endothelial Ca super( 2+)-activated K super( +) channels KCa2.3 and KCa3.1 via a Ca super( 2+)/calmodulin-dependent protein kinase kinase/Akt/p300 cascade

In endothelial cells (ECs), Ca2+-activated K+ channels KCa2.3 and KCa3.1 play a crucial role in the regulation of arterial tone via producing NO and endothelium-derived hyperpolarizing factors. Since a rise in intracellular Ca2+ levels and activation of p300 histone acetyltransferase are early EC re...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2013-08, Vol.305 (4), p.H484-H484
Hauptverfasser:	Takai, Jun, Santu, Alexandra, Zheng, Haifeng, Koh, Sang Don, Ohta, Masanori, Filimban, Linda M, Lemaitre, Vincent, Teraoka, Ryutaro, Jo, Hanjoong, Miura, Hiroto
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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