Sonodynamically-induced anticancer effects by functionalized fullerenes
Functionalized fullerenes, such as polyhydroxy fullerenes (PHF), have attracted particular attention due to their water solubility and their potential application in tumor imaging and therapy as carbon nanomaterials. In this study, the sonodynamically-induced antitumor effect of PHF was investigated...
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| Veröffentlicht in: | Anticancer research 2013-08, Vol.33 (8), p.3145-3151 |
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| container_title | Anticancer research |
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| creator | Yumita, Nagahiko Iwase, Yumiko Imaizumi, Takahiro Sakurazawa, Ai Kaya, Yuuka Nishi, Koji Ikeda, Toshihiko Umemura, Shin-Ichiro Chen, Fu-Shih Momose, Yasunori |
| description | Functionalized fullerenes, such as polyhydroxy fullerenes (PHF), have attracted particular attention due to their water solubility and their potential application in tumor imaging and therapy as carbon nanomaterials. In this study, the sonodynamically-induced antitumor effect of PHF was investigated.
Sonodynamically-induced antitumor effects of PHF in combination with ultrasound were investigated using isolated sarcoma 180 cells and solid tumor from colon 26 carcinoma cells.
The cell damage induced by sonication was enhanced by two-fold in the presence of 80 μM PHF. Histidine significantly inhibited this enhancement. This inhibitory effect suggests that the sonodynamically-induced antitumor effect was mediated by sonodynamically-generated reactive oxygen species. The combined treatment of ultrasonic exposure with PHF suppressed the growth of implanted colon 26 tumors. The destruction of tumor tissue was observed with the ultrasonic treatment in combination with PHF, while neither the treatment with PHF alone nor that with ultrasound alone caused necrosis.
These results suggest that PHF is a potential sonosensitizer for sonodynamic treatment of solid tumors. |
| format | Article |
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Sonodynamically-induced antitumor effects of PHF in combination with ultrasound were investigated using isolated sarcoma 180 cells and solid tumor from colon 26 carcinoma cells.
The cell damage induced by sonication was enhanced by two-fold in the presence of 80 μM PHF. Histidine significantly inhibited this enhancement. This inhibitory effect suggests that the sonodynamically-induced antitumor effect was mediated by sonodynamically-generated reactive oxygen species. The combined treatment of ultrasonic exposure with PHF suppressed the growth of implanted colon 26 tumors. The destruction of tumor tissue was observed with the ultrasonic treatment in combination with PHF, while neither the treatment with PHF alone nor that with ultrasound alone caused necrosis.
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Sonodynamically-induced antitumor effects of PHF in combination with ultrasound were investigated using isolated sarcoma 180 cells and solid tumor from colon 26 carcinoma cells.
The cell damage induced by sonication was enhanced by two-fold in the presence of 80 μM PHF. Histidine significantly inhibited this enhancement. This inhibitory effect suggests that the sonodynamically-induced antitumor effect was mediated by sonodynamically-generated reactive oxygen species. The combined treatment of ultrasonic exposure with PHF suppressed the growth of implanted colon 26 tumors. The destruction of tumor tissue was observed with the ultrasonic treatment in combination with PHF, while neither the treatment with PHF alone nor that with ultrasound alone caused necrosis.
These results suggest that PHF is a potential sonosensitizer for sonodynamic treatment of solid tumors.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Cell Separation</subject><subject>Free Radical Scavengers - metabolism</subject><subject>Fullerenes - chemistry</subject><subject>Fullerenes - therapeutic use</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred ICR</subject><subject>Nitrogen Oxides - metabolism</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Sarcoma 180 - drug therapy</subject><subject>Sarcoma 180 - metabolism</subject><subject>Sarcoma 180 - pathology</subject><subject>Ultrasonic Therapy</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0MtKxDAYBeAgijOOvoJ06aaQ5t6lDDoKAy7UdcnlD0TStDbNoj69Bcf9rA4cPs7iXKBtI9umlpziS7TFhONaYsw36CbnL4yFaBW9RhtCVauwJFt0eB_S4Jak-2B1jEsdkisWXKXTvDbJwlSB92DnXJml8iXZOQxJx_CzIl9ihAkS5Ft05XXMcHfKHfp8fvrYv9THt8Pr_vFYj4SxuTZSeMGJAeOttowyZpxWLfHceMCmFUAocUw0THIphHBegSWcKMuwpBboDj387Y7T8F0gz10fsoUYdYKh5K5hXHEqJGNn0EZgRlpOVnp_osX04LpxCr2elu7_J_oLYElluw</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Yumita, Nagahiko</creator><creator>Iwase, Yumiko</creator><creator>Imaizumi, Takahiro</creator><creator>Sakurazawa, Ai</creator><creator>Kaya, Yuuka</creator><creator>Nishi, Koji</creator><creator>Ikeda, Toshihiko</creator><creator>Umemura, Shin-Ichiro</creator><creator>Chen, Fu-Shih</creator><creator>Momose, Yasunori</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201308</creationdate><title>Sonodynamically-induced anticancer effects by functionalized fullerenes</title><author>Yumita, Nagahiko ; 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In this study, the sonodynamically-induced antitumor effect of PHF was investigated.
Sonodynamically-induced antitumor effects of PHF in combination with ultrasound were investigated using isolated sarcoma 180 cells and solid tumor from colon 26 carcinoma cells.
The cell damage induced by sonication was enhanced by two-fold in the presence of 80 μM PHF. Histidine significantly inhibited this enhancement. This inhibitory effect suggests that the sonodynamically-induced antitumor effect was mediated by sonodynamically-generated reactive oxygen species. The combined treatment of ultrasonic exposure with PHF suppressed the growth of implanted colon 26 tumors. The destruction of tumor tissue was observed with the ultrasonic treatment in combination with PHF, while neither the treatment with PHF alone nor that with ultrasound alone caused necrosis.
These results suggest that PHF is a potential sonosensitizer for sonodynamic treatment of solid tumors.</abstract><cop>Greece</cop><pmid>23898072</pmid><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Cell Line, Tumor Cell Proliferation Cell Separation Free Radical Scavengers - metabolism Fullerenes - chemistry Fullerenes - therapeutic use Male Mice Mice, Inbred BALB C Mice, Inbred ICR Nitrogen Oxides - metabolism Reactive Oxygen Species - metabolism Sarcoma 180 - drug therapy Sarcoma 180 - metabolism Sarcoma 180 - pathology Ultrasonic Therapy |
| title | Sonodynamically-induced anticancer effects by functionalized fullerenes |
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