Osseointegration of dental implants and osteonecrosis of the jaw in patients treated with bisphosphonate therapy: a systematic review
Bisphosphonate (BP) drugs are a commonly prescribed group of medications used in the treatment of metabolic and oncologic bone disorders. The aim of this study was to conduct a systematic review in order to evaluate whether patients on BP therapy are appropriate candidates for dental implants as com...
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| Veröffentlicht in: | The Journal of oral implantology 2013-08, Vol.39 (4), p.510-520 |
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| container_title | The Journal of oral implantology |
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| creator | Chadha, Gurpreet K Ahmadieh, Azadeh Kumar, Satish Sedghizadeh, Parish P |
| description | Bisphosphonate (BP) drugs are a commonly prescribed group of medications used in the treatment of metabolic and oncologic bone disorders. The aim of this study was to conduct a systematic review in order to evaluate whether patients on BP therapy are appropriate candidates for dental implants as compared to patients not taking BP drugs with respect to successful implant osseointegration and the risk of developing bisphosphonate-related osteonecrosis of the jaw. Based on the current literature, a history of oral or intravenous BP use is not an absolute contraindication for dental implant placement, and dental implants can osseointegrate successfully in this patient population. Importantly, the studies currently available on this topic are of moderate to weak strength of evidence with inherent bias and limitations, and hence results must be interpreted in this context. Well-controlled studies with higher strength of evidence and larger population sizes are required to address this topic more accurately in the future. |
| doi_str_mv | 10.1563/AAID-JOI-D-11-00234 |
| format | Article |
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The aim of this study was to conduct a systematic review in order to evaluate whether patients on BP therapy are appropriate candidates for dental implants as compared to patients not taking BP drugs with respect to successful implant osseointegration and the risk of developing bisphosphonate-related osteonecrosis of the jaw. Based on the current literature, a history of oral or intravenous BP use is not an absolute contraindication for dental implant placement, and dental implants can osseointegrate successfully in this patient population. Importantly, the studies currently available on this topic are of moderate to weak strength of evidence with inherent bias and limitations, and hence results must be interpreted in this context. Well-controlled studies with higher strength of evidence and larger population sizes are required to address this topic more accurately in the future.</description><identifier>ISSN: 0160-6972</identifier><identifier>EISSN: 1548-1336</identifier><identifier>DOI: 10.1563/AAID-JOI-D-11-00234</identifier><identifier>PMID: 23964780</identifier><language>eng</language><publisher>United States: Allen Press Inc</publisher><subject>Bisphosphonate-Associated Osteonecrosis of the Jaw ; Bisphosphonates ; Bone density ; Bone Density Conservation Agents - therapeutic use ; Decision making ; Dental Implantation, Endosseous ; Dentistry ; Diphosphonates - therapeutic use ; Humans ; Osseointegration ; Patients ; Risk Assessment ; Studies ; Success ; Transplants & implants</subject><ispartof>The Journal of oral implantology, 2013-08, Vol.39 (4), p.510-520</ispartof><rights>Copyright Allen Press Publishing Services 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-f3978b2d36db7f48eccbf15c4954a86d7b405d92b7f4f6ead90179b0a2ffb60d3</citedby><cites>FETCH-LOGICAL-c391t-f3978b2d36db7f48eccbf15c4954a86d7b405d92b7f4f6ead90179b0a2ffb60d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23964780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chadha, Gurpreet K</creatorcontrib><creatorcontrib>Ahmadieh, Azadeh</creatorcontrib><creatorcontrib>Kumar, Satish</creatorcontrib><creatorcontrib>Sedghizadeh, Parish P</creatorcontrib><title>Osseointegration of dental implants and osteonecrosis of the jaw in patients treated with bisphosphonate therapy: a systematic review</title><title>The Journal of oral implantology</title><addtitle>J Oral Implantol</addtitle><description>Bisphosphonate (BP) drugs are a commonly prescribed group of medications used in the treatment of metabolic and oncologic bone disorders. 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Well-controlled studies with higher strength of evidence and larger population sizes are required to address this topic more accurately in the future.</description><subject>Bisphosphonate-Associated Osteonecrosis of the Jaw</subject><subject>Bisphosphonates</subject><subject>Bone density</subject><subject>Bone Density Conservation Agents - therapeutic use</subject><subject>Decision making</subject><subject>Dental Implantation, Endosseous</subject><subject>Dentistry</subject><subject>Diphosphonates - therapeutic use</subject><subject>Humans</subject><subject>Osseointegration</subject><subject>Patients</subject><subject>Risk Assessment</subject><subject>Studies</subject><subject>Success</subject><subject>Transplants & implants</subject><issn>0160-6972</issn><issn>1548-1336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc1uEzEURi0EoiHwBEjIEhs2A_b4b4Zd1EAbVCmbdm15xtfEUWY82E6jPEDfGw8tLFh1YVmyz_dJ9x6E3lPymQrJvqxWm3X1Y7up1hWlFSE14y_QggreVJQx-RItCJWkkq2qL9CblPYFEULQ1-iiZq3kqiEL9LBNCYIfM_yMJvsw4uCwhTGbA_bDdDBjTtiMFoeUIYzQx5B8mqG8A7w3J-xHPJUkzGCOYDJYfPJ5hzufpl2Yz1geZz6a6fwVG5zOpWwooR5HuPdweoteOXNI8O7pXqK7799uL6-rm-3V5nJ1U_WspblyrFVNV1smbaccb6DvO0dFz1vBTSOt6jgRtq3nTyfB2JZQ1XbE1M51kli2RJ8ee6cYfh0hZT341MOhjAnhmDTlohGMldgz0Fop3jZUFfTjf-g-HONYBilUwSRRRcgSsUdqXmGK4PQU_WDiWVOiZ6F6FqqLUL3WlOo_Qkvqw1P3sRvA_sv8Nch-A4-3nys</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Chadha, Gurpreet K</creator><creator>Ahmadieh, Azadeh</creator><creator>Kumar, Satish</creator><creator>Sedghizadeh, Parish P</creator><general>Allen Press Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20130801</creationdate><title>Osseointegration of dental implants and osteonecrosis of the jaw in patients treated with bisphosphonate therapy: a systematic review</title><author>Chadha, Gurpreet K ; 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| ispartof | The Journal of oral implantology, 2013-08, Vol.39 (4), p.510-520 |
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| source | MEDLINE; Allen Press Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Bisphosphonate-Associated Osteonecrosis of the Jaw Bisphosphonates Bone density Bone Density Conservation Agents - therapeutic use Decision making Dental Implantation, Endosseous Dentistry Diphosphonates - therapeutic use Humans Osseointegration Patients Risk Assessment Studies Success Transplants & implants |
| title | Osseointegration of dental implants and osteonecrosis of the jaw in patients treated with bisphosphonate therapy: a systematic review |
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