Effect of Zinc Oxide Nanoparticles on the Function of MC3T3-E1 Osteoblastic Cells

Zinc oxide nanoparticles (ZnO NPs) can be ingested directly when used in food, food packaging, drug delivery, and cosmetics. This study evaluated the cellular effects of ZnO NPs (50 and 100 nm diameter particle sizes) on the function of osteoblastic MC3T3-E1 cells. ZnO NPs showed cytotoxicity at con...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biological trace element research 2013-11, Vol.155 (2), p.287-294
Hauptverfasser:	Suh, Kwang Sik, Lee, Young Soon, Seo, Seung Hwan, Kim, Young Seol, Choi, Eun Mi
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine triphosphate alkaline phosphatase Animals Antimycin A - antagonists & inhibitors Antimycin A - pharmacology Biochemistry Biomedical and Life Sciences Biotechnology Bones cell viability Cells, Cultured Cellular biology collagen Cosmetics Cytotoxicity Dose-Response Relationship, Drug Food packaging Gene expression Inactivation Life Sciences membrane potential Membrane Potential, Mitochondrial - drug effects Mice Mineralization Mitochondria - drug effects Mitochondria - metabolism mitochondrial membrane Nanoparticles Nanoparticles - chemistry Nutrition Oncology osteoblasts Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism osteocalcin protective effect reactive oxygen species Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Structure-Activity Relationship zinc oxide Zinc Oxide - chemistry Zinc Oxide - pharmacology Zinc oxides
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Zinc oxide nanoparticles (ZnO NPs) can be ingested directly when used in food, food packaging, drug delivery, and cosmetics. This study evaluated the cellular effects of ZnO NPs (50 and 100 nm diameter particle sizes) on the function of osteoblastic MC3T3-E1 cells. ZnO NPs showed cytotoxicity at concentrations of above 50 μg/ml, and there was no significant effect of the size on the cytotoxicity of ZnO NPs. Within the testing concentrations of 0.01∼1 μg/ml, which did not cause a marked drop in cell viability, ZnO NPs (0.1 μg/ml) caused a significant elevation of alkaline phosphatase activity, collagen synthesis, mineralization, and osteocalcin content in the cells (P
ISSN:	0163-4984 1559-0720
DOI:	10.1007/s12011-013-9772-y