Celecoxib enhances the efficacy of 15-hydroxyprostaglandin dehydrogenase gene therapy in treating murine breast cancer

Purpose The overexpression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) has been proved to inhibit tumor growth and metastasis through degradation of prostaglandin E2 (PGE2), which is often overexpressed in various cancers and accelerates tumor progression. Cyclooxygenase-2 (COX-2), a synthase...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2013-05, Vol.139 (5), p.797-807
Hauptverfasser:	Zhang, Binglan, Ma, Xuelei, Li, Zhimian, Gao, Xiang, Wang, Fengtian, Liu, Lei, Shen, Guobo, Sang, Yaxiong, Li, Minmin, Li, Yuli, Zhao, Jingyi, Wei, Yuquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences Breast cancer Cancer Research Celecoxib Cell Line, Tumor Combined Modality Therapy Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - administration & dosage Cyclooxygenase 2 Inhibitors - adverse effects Dinoprostone - metabolism Disease Models, Animal Female Gene therapy Genetic Therapy - adverse effects Gynecology. Andrology. Obstetrics Hematology Humans Hydroxyprostaglandin Dehydrogenases - genetics Hydroxyprostaglandin Dehydrogenases - metabolism Inhibitor drugs Internal Medicine Lung Neoplasms - pathology Lung Neoplasms - secondary Mammary gland diseases Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - pathology Mammary Neoplasms, Experimental - therapy Medical sciences Medicine Medicine & Public Health Mice Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Myeloid Cells - immunology Myeloid Cells - metabolism Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - genetics Oncology Original Paper Pharmacology. Drug treatments Pyrazoles - administration & dosage Pyrazoles - adverse effects Rodents Spleen - immunology Spleen - pathology Sulfonamides - administration & dosage Sulfonamides - adverse effects Tumor Burden - drug effects Tumor Burden - genetics Tumors
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