Overexpression of Sirtuin 6 Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen‐Induced Arthritis

Objective Sirtuin 6 (SIRT‐6) is an NAD+‐dependent deacetylase and mono‐ADP‐ribosyltransferase. It is known to interfere with the NF‐κB signaling pathway and thereby has an antiinflammatory function. Due to the central role of NF‐κB in rheumatoid arthritis (RA) development, we undertook this study to...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2013-07, Vol.65 (7), p.1776-1785
Hauptverfasser:	Lee, Hwa‐Suk, Ka, Sun‐O, Lee, Sang‐Myeong, Lee, Sang‐Il, Park, Jin‐Woo, Park, Byung‐Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adenovirus Animals Arthritis Arthritis, Experimental - immunology Arthritis, Experimental - therapy Arthritis, Rheumatoid - immunology Cell Differentiation Cells Cells, Cultured Gene expression Gene Transfer Techniques Humans Inflammation Mediators - immunology Macrophages - cytology Male Medical research Mice Mice, Inbred DBA NF-kappa B - immunology Osteoclasts - cytology Proteins Signal Transduction Sirtuins - genetics Sirtuins - immunology Sirtuins - physiology Synovial Membrane - cytology Synovial Membrane - immunology Tumor Necrosis Factor-alpha - immunology Up-Regulation
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