VP22 and cytosine deaminase fusion gene modified tissue-engineered neural stem cells for glioma therapy

Purpose The herpes simplex virus type 1 tegument protein VP22 has the remarkable property of intercellular trafficking, thus making it a promising tool for improving gene transfer efficiency. Methods To investigate whether the fusion of VP22 to the cytosine deaminase (CD) suicide gene could enhance...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2013-03, Vol.139 (3), p.475-483
Hauptverfasser:	Jin, Guishan, Zhou, Yiqiang, Chai, Qi, Zhu, Guidong, Xu, Fujian, Liu, Fusheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Brain cancer Brain Neoplasms - genetics Brain Neoplasms - therapy Brain tumors Cancer Research Cells, Cultured Cytosine Deaminase - administration & dosage Cytosine Deaminase - genetics Cytosine Deaminase - metabolism Embryo, Mammalian Gene therapy Gene Transfer Techniques Genetic Therapy - methods Glioma - genetics Glioma - therapy Hematology Herpes simplex virus 1 Humans Internal Medicine Male Medical sciences Medicine Medicine & Public Health Neural Stem Cells - metabolism Neural Stem Cells - physiology Neural Stem Cells - transplantation Neurology Oncology Original Paper Pharmacology. Drug treatments Proteins Rats Rats, Sprague-Dawley Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Stem cells Tissue Engineering - methods Tumors of the nervous system. Phacomatoses Viral Structural Proteins - administration & dosage Viral Structural Proteins - genetics Viral Structural Proteins - metabolism
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