Inter-chain disulfide bond improved protein trans-splicing increases plasma coagulation activity in C57BL/6 mice following portal vein FVIII gene delivery by dual vectors

Protein trans-splicing based dual-vector factor VIII （FVIII） gene delivery is adversely affected by less efficiency of protein splicing. We sought to increase the amount of spliced FVIII protein and plasma coagulation activity in dual-vector FVIII transgene in mice by means of strengthening the inte...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science China. Life sciences 2013-03, Vol.56 (3), p.262-267
Hauptverfasser:	Zhu, FuXiang, Liu, ZeLong, Wang, XiaoLei, Miao, Jing, Qu, HuiGe, Chi, XiaoYan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Biomedical and Life Sciences Blood Coagulation Cysteine - chemistry Cysteine - genetics Cysteine - metabolism Disulfides - chemistry Disulfides - metabolism Enzyme-Linked Immunosorbent Assay Factor VIII - chemistry Factor VIII - genetics Factor VIII - metabolism Gene Transfer Techniques Genetic Vectors - administration & dosage Genetic Vectors - genetics Humans Inteins - genetics I基因 Life Sciences Mice Mice, Inbred C57BL Mice, Transgenic Mutation Portal Vein Protein Splicing Recombinant Fusion Proteins - blood Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Research Paper 二硫键凝血活性反式剪接小鼠轻链门静脉高蛋白质
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!