Selenium and Topiramate Attenuates Blood Oxidative Toxicity in Patients with Epilepsy: A Clinical Pilot Study
It is well known that oxidative stress plays an important role in the etiology of epilepsy. We investigated effects of selenium (Se) and topiramate (TPM) combination supplementation on antioxidant and oxidant values in control and patients with epilepsy and refractory epilepsy. For the aim, we used...
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| Veröffentlicht in: | Biological trace element research 2013-05, Vol.152 (2), p.180-186 |
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| description | It is well known that oxidative stress plays an important role in the etiology of epilepsy. We investigated effects of selenium (Se) and topiramate (TPM) combination supplementation on antioxidant and oxidant values in control and patients with epilepsy and refractory epilepsy. For the aim, we used control (n = 19), epilepsy + TPM (n = 19), epilepsy + TPM + Se (n = 15) groups. We also used control (n = 15), refractory epilepsy (n = 15), and refractory epilepsy + Se (n = 8) groups. TPM (0.2 mg/daily) and Se, as sodium selenite (twice daily with 0.1 mg doses), were orally supplemented to the patients for 45 days. Erythrocyte lipid peroxidation levels were higher in refractory epilepsy groups than in control although its level and seizure numbers were decreased in TPM and TPM + Se supplemented groups of the patients. The erythrocyte reduced glutathione (GSH), glutathione peroxidase (GSH-Px), plasma total antioxidant status (TAS), and vitamin E concentration in refractory epilepsy group were lower than in control. However, the erythrocyte and plasma TAS, erythrocyte GSH and GSH-Px, and plasma vitamins A and C values were increased either by Se or Se + TPM in epilepsy and refractory epilepsy groups. There were no effects of TPM and Se on plasma β-carotene values in the groups. In conclusion, TPM and selenium caused protective effects on the epilepsy and refractory epilepsy-induced oxidative injury by inhibiting free radical production and supporting antioxidant redox system. |
| doi_str_mv | 10.1007/s12011-013-9616-9 |
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We investigated effects of selenium (Se) and topiramate (TPM) combination supplementation on antioxidant and oxidant values in control and patients with epilepsy and refractory epilepsy. For the aim, we used control (n = 19), epilepsy + TPM (n = 19), epilepsy + TPM + Se (n = 15) groups. We also used control (n = 15), refractory epilepsy (n = 15), and refractory epilepsy + Se (n = 8) groups. TPM (0.2 mg/daily) and Se, as sodium selenite (twice daily with 0.1 mg doses), were orally supplemented to the patients for 45 days. Erythrocyte lipid peroxidation levels were higher in refractory epilepsy groups than in control although its level and seizure numbers were decreased in TPM and TPM + Se supplemented groups of the patients. The erythrocyte reduced glutathione (GSH), glutathione peroxidase (GSH-Px), plasma total antioxidant status (TAS), and vitamin E concentration in refractory epilepsy group were lower than in control. However, the erythrocyte and plasma TAS, erythrocyte GSH and GSH-Px, and plasma vitamins A and C values were increased either by Se or Se + TPM in epilepsy and refractory epilepsy groups. There were no effects of TPM and Se on plasma β-carotene values in the groups. In conclusion, TPM and selenium caused protective effects on the epilepsy and refractory epilepsy-induced oxidative injury by inhibiting free radical production and supporting antioxidant redox system.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-013-9616-9</identifier><identifier>PMID: 23389846</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adult ; Antioxidants ; Antioxidants - metabolism ; Ascorbic Acid - blood ; beta Carotene - blood ; beta-carotene ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Blood ; Case-Control Studies ; Epilepsy ; Epilepsy - blood ; Epilepsy - drug therapy ; Epilepsy - metabolism ; Erythrocytes ; etiology ; Female ; Fructose - analogs & derivatives ; Fructose - therapeutic use ; glutathione ; Glutathione - metabolism ; glutathione peroxidase ; Glutathione Peroxidase - metabolism ; Humans ; Life Sciences ; lipid peroxidation ; Lipid Peroxidation - drug effects ; Male ; Nutrition ; Oncology ; oxidants ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidizing agents ; patients ; Peroxidation ; Pilot Projects ; protective effect ; Selenium ; Selenium - therapeutic use ; sodium selenite ; Toxicity ; Vitamin A - blood ; vitamin E ; Vitamin E - blood ; Vitamins ; Young Adult</subject><ispartof>Biological trace element research, 2013-05, Vol.152 (2), p.180-186</ispartof><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-313eb10c442efadcfec4e595d74c57b0e6c403506289f7388a4e251ae84342133</citedby><cites>FETCH-LOGICAL-c429t-313eb10c442efadcfec4e595d74c57b0e6c403506289f7388a4e251ae84342133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-013-9616-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-013-9616-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23389846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yürekli, Vedat Ali</creatorcontrib><creatorcontrib>Nazirolu, Mustafa</creatorcontrib><title>Selenium and Topiramate Attenuates Blood Oxidative Toxicity in Patients with Epilepsy: A Clinical Pilot Study</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>It is well known that oxidative stress plays an important role in the etiology of epilepsy. We investigated effects of selenium (Se) and topiramate (TPM) combination supplementation on antioxidant and oxidant values in control and patients with epilepsy and refractory epilepsy. For the aim, we used control (n = 19), epilepsy + TPM (n = 19), epilepsy + TPM + Se (n = 15) groups. We also used control (n = 15), refractory epilepsy (n = 15), and refractory epilepsy + Se (n = 8) groups. TPM (0.2 mg/daily) and Se, as sodium selenite (twice daily with 0.1 mg doses), were orally supplemented to the patients for 45 days. Erythrocyte lipid peroxidation levels were higher in refractory epilepsy groups than in control although its level and seizure numbers were decreased in TPM and TPM + Se supplemented groups of the patients. The erythrocyte reduced glutathione (GSH), glutathione peroxidase (GSH-Px), plasma total antioxidant status (TAS), and vitamin E concentration in refractory epilepsy group were lower than in control. However, the erythrocyte and plasma TAS, erythrocyte GSH and GSH-Px, and plasma vitamins A and C values were increased either by Se or Se + TPM in epilepsy and refractory epilepsy groups. There were no effects of TPM and Se on plasma β-carotene values in the groups. In conclusion, TPM and selenium caused protective effects on the epilepsy and refractory epilepsy-induced oxidative injury by inhibiting free radical production and supporting antioxidant redox system.</description><subject>Adult</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Ascorbic Acid - blood</subject><subject>beta Carotene - blood</subject><subject>beta-carotene</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Blood</subject><subject>Case-Control Studies</subject><subject>Epilepsy</subject><subject>Epilepsy - blood</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - metabolism</subject><subject>Erythrocytes</subject><subject>etiology</subject><subject>Female</subject><subject>Fructose - analogs & derivatives</subject><subject>Fructose - therapeutic use</subject><subject>glutathione</subject><subject>Glutathione - metabolism</subject><subject>glutathione peroxidase</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>oxidants</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidizing agents</subject><subject>patients</subject><subject>Peroxidation</subject><subject>Pilot Projects</subject><subject>protective effect</subject><subject>Selenium</subject><subject>Selenium - therapeutic use</subject><subject>sodium selenite</subject><subject>Toxicity</subject><subject>Vitamin A - blood</subject><subject>vitamin E</subject><subject>Vitamin E - blood</subject><subject>Vitamins</subject><subject>Young Adult</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kVtrFTEUhYMo9lj9Ab5owBdfRrNzmZn4djzUCxRaOO1zyMnsqSmZi0lGe_69KVNFfBACCTvfWnuzFyEvgb0Dxpr3CTgDqBiIStdQV_oR2YBSumINZ4_JhkEtKqlbeUKepXTLGDRci6fkhAvRlnK9IcMeA45-GagdO3o1zT7awWak25xxXMor0Y9hmjp6cec7m_0PLNSddz4fqR_pZSnhmBP96fM3ejb7gHM6fqBbugt-9M4GeunDlOk-L93xOXnS25DwxcN9Sq4_nV3tvlTnF5-_7rbnlZNc50qAwAMwJyXH3nauRydRadU10qnmwLB2kgnFat7qvhFtayVyBRZbKSQHIU7J29V3jtP3BVM2g08OQ7AjTksyIFWruGygKeibf9DbaYljmc6A4HU5SkOhYKVcnFKK2Js5-sHGowFm7rMwaxamZGHuszC6aF49OC-HAbs_it_LLwBfgVS-xhuMf7X-j-vrVdTbydib6JO53hdIlnRbxqQWvwBNu5yg</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Yürekli, Vedat Ali</creator><creator>Nazirolu, Mustafa</creator><general>Springer-Verlag</general><general>Humana Press Inc</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7TK</scope><scope>7TV</scope></search><sort><creationdate>20130501</creationdate><title>Selenium and Topiramate Attenuates Blood Oxidative Toxicity in Patients with Epilepsy: A Clinical Pilot Study</title><author>Yürekli, Vedat Ali ; Nazirolu, Mustafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-313eb10c442efadcfec4e595d74c57b0e6c403506289f7388a4e251ae84342133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Antioxidants</topic><topic>Antioxidants - 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We investigated effects of selenium (Se) and topiramate (TPM) combination supplementation on antioxidant and oxidant values in control and patients with epilepsy and refractory epilepsy. For the aim, we used control (n = 19), epilepsy + TPM (n = 19), epilepsy + TPM + Se (n = 15) groups. We also used control (n = 15), refractory epilepsy (n = 15), and refractory epilepsy + Se (n = 8) groups. TPM (0.2 mg/daily) and Se, as sodium selenite (twice daily with 0.1 mg doses), were orally supplemented to the patients for 45 days. Erythrocyte lipid peroxidation levels were higher in refractory epilepsy groups than in control although its level and seizure numbers were decreased in TPM and TPM + Se supplemented groups of the patients. The erythrocyte reduced glutathione (GSH), glutathione peroxidase (GSH-Px), plasma total antioxidant status (TAS), and vitamin E concentration in refractory epilepsy group were lower than in control. However, the erythrocyte and plasma TAS, erythrocyte GSH and GSH-Px, and plasma vitamins A and C values were increased either by Se or Se + TPM in epilepsy and refractory epilepsy groups. There were no effects of TPM and Se on plasma β-carotene values in the groups. In conclusion, TPM and selenium caused protective effects on the epilepsy and refractory epilepsy-induced oxidative injury by inhibiting free radical production and supporting antioxidant redox system.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>23389846</pmid><doi>10.1007/s12011-013-9616-9</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Antioxidants Antioxidants - metabolism Ascorbic Acid - blood beta Carotene - blood beta-carotene Biochemistry Biomedical and Life Sciences Biotechnology Blood Case-Control Studies Epilepsy Epilepsy - blood Epilepsy - drug therapy Epilepsy - metabolism Erythrocytes etiology Female Fructose - analogs & derivatives Fructose - therapeutic use glutathione Glutathione - metabolism glutathione peroxidase Glutathione Peroxidase - metabolism Humans Life Sciences lipid peroxidation Lipid Peroxidation - drug effects Male Nutrition Oncology oxidants Oxidative stress Oxidative Stress - drug effects Oxidizing agents patients Peroxidation Pilot Projects protective effect Selenium Selenium - therapeutic use sodium selenite Toxicity Vitamin A - blood vitamin E Vitamin E - blood Vitamins Young Adult |
| title | Selenium and Topiramate Attenuates Blood Oxidative Toxicity in Patients with Epilepsy: A Clinical Pilot Study |
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