Interdomain Dynamics Explored by Paramagnetic NMR

An ensemble-based approach is presented to explore the conformational space sampled by a multidomain protein showing moderate interdomain dynamics in terms of translational and rotational motions. The strategy was applied on a complex of calmodulin (CaM) with the IQ-recognition motif from the voltag...

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Veröffentlicht in:	Journal of the American Chemical Society 2013-11, Vol.135 (45), p.17111-17120
Hauptverfasser:	Russo, Luigi, Maestre-Martinez, Mitcheell, Wolff, Sebastian, Becker, Stefan, Griesinger, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium Channels, L-Type - chemistry Calcium Channels, L-Type - metabolism Calmodulin - chemistry Calmodulin - metabolism Humans Molecular Dynamics Simulation Nuclear Magnetic Resonance, Biomolecular - methods Protein Conformation Protein Structure, Tertiary
Online-Zugang:	Volltext
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