In vivo study of the complement system during infusion of radiographic contrast media
It has been claimed that activation of the complement system may play a role in reaction to radiographic contrast media (RCM) infusion. In order to clarify the effects of RCM on the complement system, three different parameters (CH50, C3a, and Cl inhibitor) were measured in 20 patients undergoing in...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 1986-05, Vol.77 (5), p.690-692 |
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| container_end_page | 692 |
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| container_issue | 5 |
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| container_title | Journal of allergy and clinical immunology |
| container_volume | 77 |
| creator | Gardinali, Marco Cicardi, Marco Frangi, Donatella Franzinelli, Massimo Gattoni, Filippo Uslenghi, Carlo Agostoni, Angelo |
| description | It has been claimed that activation of the complement system may play a role in reaction to radiographic contrast media (RCM) infusion. In order to clarify the effects of RCM on the complement system, three different parameters (CH50, C3a, and Cl inhibitor) were measured in 20 patients undergoing intravenous pyelography for diagnostic purposes. We found no significant changes in C3a levels, but CH50 and Cl inhibitor fell significantly at the different sampling times; however, the decreases lost significance when the data were corrected for hemodilution with the total protein content of each sample as a reference. We conclude that RCM infusion does not activate the complement system. |
| doi_str_mv | 10.1016/0091-6749(86)90411-2 |
| format | Article |
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In order to clarify the effects of RCM on the complement system, three different parameters (CH50, C3a, and Cl inhibitor) were measured in 20 patients undergoing intravenous pyelography for diagnostic purposes. We found no significant changes in C3a levels, but CH50 and Cl inhibitor fell significantly at the different sampling times; however, the decreases lost significance when the data were corrected for hemodilution with the total protein content of each sample as a reference. We conclude that RCM infusion does not activate the complement system.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/0091-6749(86)90411-2</identifier><identifier>PMID: 3700893</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Biological and medical sciences ; Complement Activation ; Contrast Media - adverse effects ; Contrast media. 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In order to clarify the effects of RCM on the complement system, three different parameters (CH50, C3a, and Cl inhibitor) were measured in 20 patients undergoing intravenous pyelography for diagnostic purposes. We found no significant changes in C3a levels, but CH50 and Cl inhibitor fell significantly at the different sampling times; however, the decreases lost significance when the data were corrected for hemodilution with the total protein content of each sample as a reference. We conclude that RCM infusion does not activate the complement system.</description><subject>Biological and medical sciences</subject><subject>Complement Activation</subject><subject>Contrast Media - adverse effects</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Drug Hypersensitivity - etiology</subject><subject>Hemodilution</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Radiopharmaceuticals</topic><topic>Drug Hypersensitivity - etiology</topic><topic>Hemodilution</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. 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| ispartof | Journal of allergy and clinical immunology, 1986-05, Vol.77 (5), p.690-692 |
| issn | 0091-6749 1097-6825 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences Complement Activation Contrast Media - adverse effects Contrast media. Radiopharmaceuticals Drug Hypersensitivity - etiology Hemodilution Humans Medical sciences Pharmacology. Drug treatments |
| title | In vivo study of the complement system during infusion of radiographic contrast media |
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