Inhibition of yeast cytosine deaminase by 5-bromo-2-pyrimidinone and its covalent hydrate

Yeast cytosine deaminase (EC 3.5.4.1) is inhibited by 5‐bromo‐2‐pyrimidinone. In aqueous solution at neutral pH three forms of this compound (the anion, the parent, and the covalent hydrate) are in equilibrium. Experiments were undertaken in order to determine the relative contributions of these thr...

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Veröffentlicht in:	European journal of biochemistry 1986, Vol.156 (2), p.297-300
Hauptverfasser:	Kornblatt, M.J, Tee, O.S
Format:	Artikel
Sprache:	eng
Schlagworte:	5-bromo-2-pyrimidinone Applied sciences bakers yeast cytosine Cytosine Deaminase enzyme activity Exact sciences and technology Hydrogen-Ion Concentration inhibition Kinetics Nucleoside Deaminases - antagonists & inhibitors Other techniques and industries Pyrimidinones - pharmacology Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology
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