Nongenomic bronchodilating action elicited by dehydroepiandrosterone (DHEA) in a guinea pig asthma model

•DHEA is a bronchoactive steroid by inducing an acute airway smooth muscle relaxation.•DHEA induces airway smooth muscle relaxation.•DHEA acutely prevents and retards the bronchospasm.•The age-related decline in DHEA may be implicated in exacerbation of asthma.•DHEA plays an important role in the as...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2013-11, Vol.138, p.174-182
Hauptverfasser:	Espinoza, Julia, Montaño, Luis M., Perusquía, Mercedes
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal steroid Airway smooth muscle Animals Asthma Bronchial Spasm - prevention & control Bronchorelaxation Dehydroepiandrosterone Dehydroepiandrosterone - pharmacology DHEA Guinea Pigs In Vitro Techniques Male Muscle Relaxation - drug effects Muscle, Smooth - drug effects Muscle, Smooth - physiology Trachea - drug effects Trachea - physiology
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