Prenatal exposure to hexachlorobenzene (HCB) and reproductive effects in a multicentre birth cohort in Spain
To investigate the possible association between birth size or gestational length and maternal serum concentrations of hexachlorobenzene (HCB) in a population exposed to background levels. A total of 1568 mother–child pairs recruited in three Spanish areas (INMA Project) from 2004 to 2008 participate...
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| Veröffentlicht in: | The Science of the total environment 2014-01, Vol.466-467, p.770-776 |
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| creator | Basterrechea, Mikel Lertxundi, Aitana Iñiguez, Carmen Mendez, Michelle Murcia, Mario Mozo, Imanol Goñi, Fernando Grimalt, Joan Fernández, Marieta Guxens, Mònica |
| description | To investigate the possible association between birth size or gestational length and maternal serum concentrations of hexachlorobenzene (HCB) in a population exposed to background levels.
A total of 1568 mother–child pairs recruited in three Spanish areas (INMA Project) from 2004 to 2008 participated in the study. Multivariate analysis was performed between birth weight and length, weeks of gestation, preterm birth or small for gestational age and HCB concentrations in maternal serum.
The median concentration of HCB was 45.45ng/g lipids. No association was found between HCB exposure levels and birth weight (β: −50.42 [−109.88; 9.04]), birth length (β: −0.07 [−0.32; 0.18]), gestation age (HR: 1.07 [0.94; 1.22]), small for gestational age (OR: 0.95 [0.56; 1.61]) and preterm birth (OR: 0.60 [0.29; 1.28]). Results remain similar after adjustment for other organochlorines.
Our findings support the idea that exposure to low levels of HCB does not affect the intrauterine growth nor the duration of gestation.
•This is a birth cohort study carried out in three different areas of Spain.•The median concentration of HCB in maternal serum was 45.45ng/g lipids.•HCB levels in maternal serum are not associated with birth size.•HCB levels in maternal serum are not associated with gestational length. |
| doi_str_mv | 10.1016/j.scitotenv.2013.07.053 |
| format | Article |
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A total of 1568 mother–child pairs recruited in three Spanish areas (INMA Project) from 2004 to 2008 participated in the study. Multivariate analysis was performed between birth weight and length, weeks of gestation, preterm birth or small for gestational age and HCB concentrations in maternal serum.
The median concentration of HCB was 45.45ng/g lipids. No association was found between HCB exposure levels and birth weight (β: −50.42 [−109.88; 9.04]), birth length (β: −0.07 [−0.32; 0.18]), gestation age (HR: 1.07 [0.94; 1.22]), small for gestational age (OR: 0.95 [0.56; 1.61]) and preterm birth (OR: 0.60 [0.29; 1.28]). Results remain similar after adjustment for other organochlorines.
Our findings support the idea that exposure to low levels of HCB does not affect the intrauterine growth nor the duration of gestation.
•This is a birth cohort study carried out in three different areas of Spain.•The median concentration of HCB in maternal serum was 45.45ng/g lipids.•HCB levels in maternal serum are not associated with birth size.•HCB levels in maternal serum are not associated with gestational length.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2013.07.053</identifier><identifier>PMID: 23973543</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Animals ; Birth size ; Birth Weight - drug effects ; Cohort Studies ; Crown-Rump Length ; Environmental Monitoring ; Environmental Pollutants - blood ; Environmental Pollutants - toxicity ; Female ; Fetal Development - drug effects ; Gas Chromatography-Mass Spectrometry ; Gestation length ; Gestational Age ; HCB ; Hexachlorobenzene - blood ; Hexachlorobenzene - toxicity ; Humans ; Hydrocarbons, Chlorinated - blood ; Hydrocarbons, Chlorinated - toxicity ; Infant, Newborn ; Maternal Exposure ; Multivariate Analysis ; OCs ; Pregnancy ; Pregnancy Trimester, First - drug effects ; Premature Birth - chemically induced ; Premature Birth - epidemiology ; Prenatal Exposure Delayed Effects - chemically induced ; Prenatal Exposure Delayed Effects - epidemiology ; Spain ; Young Adult</subject><ispartof>The Science of the total environment, 2014-01, Vol.466-467, p.770-776</ispartof><rights>2013 Elsevier B.V.</rights><rights>2013.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-c94f71823694bda75db373257175994b8f0daf16c55e01e4b77f7d44beb089f73</citedby><cites>FETCH-LOGICAL-c420t-c94f71823694bda75db373257175994b8f0daf16c55e01e4b77f7d44beb089f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0048969713008218$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23973543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Basterrechea, Mikel</creatorcontrib><creatorcontrib>Lertxundi, Aitana</creatorcontrib><creatorcontrib>Iñiguez, Carmen</creatorcontrib><creatorcontrib>Mendez, Michelle</creatorcontrib><creatorcontrib>Murcia, Mario</creatorcontrib><creatorcontrib>Mozo, Imanol</creatorcontrib><creatorcontrib>Goñi, Fernando</creatorcontrib><creatorcontrib>Grimalt, Joan</creatorcontrib><creatorcontrib>Fernández, Marieta</creatorcontrib><creatorcontrib>Guxens, Mònica</creatorcontrib><creatorcontrib>On behalf of the INMA project</creatorcontrib><creatorcontrib>INMA project</creatorcontrib><title>Prenatal exposure to hexachlorobenzene (HCB) and reproductive effects in a multicentre birth cohort in Spain</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>To investigate the possible association between birth size or gestational length and maternal serum concentrations of hexachlorobenzene (HCB) in a population exposed to background levels.
A total of 1568 mother–child pairs recruited in three Spanish areas (INMA Project) from 2004 to 2008 participated in the study. Multivariate analysis was performed between birth weight and length, weeks of gestation, preterm birth or small for gestational age and HCB concentrations in maternal serum.
The median concentration of HCB was 45.45ng/g lipids. No association was found between HCB exposure levels and birth weight (β: −50.42 [−109.88; 9.04]), birth length (β: −0.07 [−0.32; 0.18]), gestation age (HR: 1.07 [0.94; 1.22]), small for gestational age (OR: 0.95 [0.56; 1.61]) and preterm birth (OR: 0.60 [0.29; 1.28]). Results remain similar after adjustment for other organochlorines.
Our findings support the idea that exposure to low levels of HCB does not affect the intrauterine growth nor the duration of gestation.
•This is a birth cohort study carried out in three different areas of Spain.•The median concentration of HCB in maternal serum was 45.45ng/g lipids.•HCB levels in maternal serum are not associated with birth size.•HCB levels in maternal serum are not associated with gestational length.</description><subject>Adult</subject><subject>Animals</subject><subject>Birth size</subject><subject>Birth Weight - drug effects</subject><subject>Cohort Studies</subject><subject>Crown-Rump Length</subject><subject>Environmental Monitoring</subject><subject>Environmental Pollutants - blood</subject><subject>Environmental Pollutants - toxicity</subject><subject>Female</subject><subject>Fetal Development - drug effects</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Gestation length</subject><subject>Gestational Age</subject><subject>HCB</subject><subject>Hexachlorobenzene - blood</subject><subject>Hexachlorobenzene - toxicity</subject><subject>Humans</subject><subject>Hydrocarbons, Chlorinated - blood</subject><subject>Hydrocarbons, Chlorinated - toxicity</subject><subject>Infant, Newborn</subject><subject>Maternal Exposure</subject><subject>Multivariate Analysis</subject><subject>OCs</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First - drug effects</subject><subject>Premature Birth - chemically induced</subject><subject>Premature Birth - epidemiology</subject><subject>Prenatal Exposure Delayed Effects - chemically induced</subject><subject>Prenatal Exposure Delayed Effects - epidemiology</subject><subject>Spain</subject><subject>Young Adult</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFuFDEMhiMEokvhFSDHcpghmSSTmWNZFYpUqUgt5yiTONqsZpMlyaxKn56stu21vliyf_-2P4S-UNJSQvtv2zYbX2KBcGg7QllLZEsEe4NWdJBjQ0nXv0UrQvjQjP0oz9CHnLekhhzoe3TWsVEywdkKzb8TBF30jOFhH_OSAJeIN_CgzWaOKU4QHiEAvrhef_-KdbA4wT5Fu5jiD4DBOTAlYx-wxrtlLt5AKNVk8qlssImbmMqxe7fXPnxE75yeM3x6yufoz4-r-_V1c3P789f68qYxvCOlMSN3kg4d60c-WS2FnZhknZBUirGWBkesdrQ3QgChwCcpnbScTzCRYXSSnaOLk2-99O8CuaidzwbmWQeIS1aUi6H6i7GrUnmSmhRzTuDUPvmdTv8UJeqIWm3VC2p1RK2IVBV1nfz8tGSZdmBf5p7ZVsHlSQD11YOHdDSCYMD6VKEpG_2rS_4D7OWVYA</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Basterrechea, Mikel</creator><creator>Lertxundi, Aitana</creator><creator>Iñiguez, Carmen</creator><creator>Mendez, Michelle</creator><creator>Murcia, Mario</creator><creator>Mozo, Imanol</creator><creator>Goñi, Fernando</creator><creator>Grimalt, Joan</creator><creator>Fernández, Marieta</creator><creator>Guxens, Mònica</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140101</creationdate><title>Prenatal exposure to hexachlorobenzene (HCB) and reproductive effects in a multicentre birth cohort in Spain</title><author>Basterrechea, Mikel ; Lertxundi, Aitana ; Iñiguez, Carmen ; Mendez, Michelle ; Murcia, Mario ; Mozo, Imanol ; Goñi, Fernando ; Grimalt, Joan ; Fernández, Marieta ; Guxens, Mònica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-c94f71823694bda75db373257175994b8f0daf16c55e01e4b77f7d44beb089f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Birth size</topic><topic>Birth Weight - drug effects</topic><topic>Cohort Studies</topic><topic>Crown-Rump Length</topic><topic>Environmental Monitoring</topic><topic>Environmental Pollutants - blood</topic><topic>Environmental Pollutants - toxicity</topic><topic>Female</topic><topic>Fetal Development - drug effects</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Gestation length</topic><topic>Gestational Age</topic><topic>HCB</topic><topic>Hexachlorobenzene - blood</topic><topic>Hexachlorobenzene - toxicity</topic><topic>Humans</topic><topic>Hydrocarbons, Chlorinated - blood</topic><topic>Hydrocarbons, Chlorinated - toxicity</topic><topic>Infant, Newborn</topic><topic>Maternal Exposure</topic><topic>Multivariate Analysis</topic><topic>OCs</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First - drug effects</topic><topic>Premature Birth - chemically induced</topic><topic>Premature Birth - epidemiology</topic><topic>Prenatal Exposure Delayed Effects - chemically induced</topic><topic>Prenatal Exposure Delayed Effects - epidemiology</topic><topic>Spain</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Basterrechea, Mikel</creatorcontrib><creatorcontrib>Lertxundi, Aitana</creatorcontrib><creatorcontrib>Iñiguez, Carmen</creatorcontrib><creatorcontrib>Mendez, Michelle</creatorcontrib><creatorcontrib>Murcia, Mario</creatorcontrib><creatorcontrib>Mozo, Imanol</creatorcontrib><creatorcontrib>Goñi, Fernando</creatorcontrib><creatorcontrib>Grimalt, Joan</creatorcontrib><creatorcontrib>Fernández, Marieta</creatorcontrib><creatorcontrib>Guxens, Mònica</creatorcontrib><creatorcontrib>On behalf of the INMA project</creatorcontrib><creatorcontrib>INMA project</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Basterrechea, Mikel</au><au>Lertxundi, Aitana</au><au>Iñiguez, Carmen</au><au>Mendez, Michelle</au><au>Murcia, Mario</au><au>Mozo, Imanol</au><au>Goñi, Fernando</au><au>Grimalt, Joan</au><au>Fernández, Marieta</au><au>Guxens, Mònica</au><aucorp>On behalf of the INMA project</aucorp><aucorp>INMA project</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal exposure to hexachlorobenzene (HCB) and reproductive effects in a multicentre birth cohort in Spain</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>466-467</volume><spage>770</spage><epage>776</epage><pages>770-776</pages><issn>0048-9697</issn><eissn>1879-1026</eissn><abstract>To investigate the possible association between birth size or gestational length and maternal serum concentrations of hexachlorobenzene (HCB) in a population exposed to background levels.
A total of 1568 mother–child pairs recruited in three Spanish areas (INMA Project) from 2004 to 2008 participated in the study. Multivariate analysis was performed between birth weight and length, weeks of gestation, preterm birth or small for gestational age and HCB concentrations in maternal serum.
The median concentration of HCB was 45.45ng/g lipids. No association was found between HCB exposure levels and birth weight (β: −50.42 [−109.88; 9.04]), birth length (β: −0.07 [−0.32; 0.18]), gestation age (HR: 1.07 [0.94; 1.22]), small for gestational age (OR: 0.95 [0.56; 1.61]) and preterm birth (OR: 0.60 [0.29; 1.28]). Results remain similar after adjustment for other organochlorines.
Our findings support the idea that exposure to low levels of HCB does not affect the intrauterine growth nor the duration of gestation.
•This is a birth cohort study carried out in three different areas of Spain.•The median concentration of HCB in maternal serum was 45.45ng/g lipids.•HCB levels in maternal serum are not associated with birth size.•HCB levels in maternal serum are not associated with gestational length.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23973543</pmid><doi>10.1016/j.scitotenv.2013.07.053</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0048-9697 1879-1026 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Animals Birth size Birth Weight - drug effects Cohort Studies Crown-Rump Length Environmental Monitoring Environmental Pollutants - blood Environmental Pollutants - toxicity Female Fetal Development - drug effects Gas Chromatography-Mass Spectrometry Gestation length Gestational Age HCB Hexachlorobenzene - blood Hexachlorobenzene - toxicity Humans Hydrocarbons, Chlorinated - blood Hydrocarbons, Chlorinated - toxicity Infant, Newborn Maternal Exposure Multivariate Analysis OCs Pregnancy Pregnancy Trimester, First - drug effects Premature Birth - chemically induced Premature Birth - epidemiology Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - epidemiology Spain Young Adult |
| title | Prenatal exposure to hexachlorobenzene (HCB) and reproductive effects in a multicentre birth cohort in Spain |
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