α-Mangostin induces mitochondrial dependent apoptosis in human hepatoma SK-Hep-1 cells through inhibition of p38 MAPK pathway

α-Mangostin is a dietary xanthone that has been shown to have anti-cancer and anti-proliferative properties in various types of human cancer cells. This study investigates the molecular mechanism of the apoptosis-inducing effects of α-mangostin on human hepatocellular carcinoma (HCC) cells. We obser...

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Veröffentlicht in:	Apoptosis (London) 2013-12, Vol.18 (12), p.1548-1560
Hauptverfasser:	Hsieh, Shu-Ching, Huang, Min-Hsien, Cheng, Chun-Wen, Hung, Jyun-Hao, Yang, Shun-Fa, Hsieh, Yi-Hsien
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - physiopathology Cell Biology Cell Cycle Checkpoints - drug effects Cell Line, Tumor Cytochromes c - metabolism Humans Liver Neoplasms - drug therapy Liver Neoplasms - enzymology Liver Neoplasms - physiopathology Male Mice Mice, Inbred BALB C Mitochondria - drug effects Mitochondria - enzymology Oncology Original Paper p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Signal Transduction - drug effects Virology Xanthones - pharmacology
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