Experimental 3-nitro-4-hydroxyphenylarsonic acid toxicosis in pigs
Five times the recommended dose of 3-nitr-4-hydroxyphcnylarsonic acid (187·5 mgkg−1) induces a pathognomonic clinical syndrome in pigs. The main clinical features are not continually present but are inducible only by exercise. From day 11 on the experimental diet a nervous syndrome was inducible. Th...
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| Veröffentlicht in: | Research in veterinary science 1985-07, Vol.39 (1), p.47-51 |
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| creator | Rice, D.A. Kennedy, S. McMurray, C.H. Blanchflower, W.J. |
| description | Five times the recommended dose of 3-nitr-4-hydroxyphcnylarsonic acid (187·5 mgkg−1) induces a pathognomonic clinical syndrome in pigs. The main clinical features are not continually present but are inducible only by exercise. From day 11 on the experimental diet a nervous syndrome was inducible. This manifested as muscle tremors and clonic convulsive episodes. Paraparesis developed by day 22 and paraplegia by day 33. Liver arsenic levels plateaued at 5·4 ± 1·3 mg kg−1. The experiment confirms field observations that 3-nitro produces a characteristic toxicological syndrome, which is distinct from that of arsanilic acid. It also confirms that 3-nitro has a higher absolute toxicity than arsanilic acid in pigs as well as a tower margin of safety. |
| doi_str_mv | 10.1016/S0034-5288(18)31769-7 |
| format | Article |
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The main clinical features are not continually present but are inducible only by exercise. From day 11 on the experimental diet a nervous syndrome was inducible. This manifested as muscle tremors and clonic convulsive episodes. Paraparesis developed by day 22 and paraplegia by day 33. Liver arsenic levels plateaued at 5·4 ± 1·3 mg kg−1. The experiment confirms field observations that 3-nitro produces a characteristic toxicological syndrome, which is distinct from that of arsanilic acid. It also confirms that 3-nitro has a higher absolute toxicity than arsanilic acid in pigs as well as a tower margin of safety.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/S0034-5288(18)31769-7</identifier><identifier>PMID: 4035090</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acids ; Animals ; Arsanilic Acid - poisoning ; Arsenic ; Arsenic - metabolism ; Arsenic Poisoning ; Erythema - veterinary ; Feces - analysis ; Kidney - metabolism ; Liver ; Liver - metabolism ; Muscles ; Paraplegia ; Paraplegia - veterinary ; Roxarsone - poisoning ; Seizures - veterinary ; Swine ; Swine Diseases - metabolism ; Swine Diseases - physiopathology ; Syndrome - veterinary ; Time Factors ; Toxicity ; Toxicosis ; Tremors ; Veterinary medicine</subject><ispartof>Research in veterinary science, 1985-07, Vol.39 (1), p.47-51</ispartof><rights>1985</rights><rights>Copyright Elsevier Limited Jul 1985</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-c50ef1e93853757732eba1296c9256c815ddc9e9e35fc2f9b4531ae362c456003</citedby><cites>FETCH-LOGICAL-c419t-c50ef1e93853757732eba1296c9256c815ddc9e9e35fc2f9b4531ae362c456003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0034-5288(18)31769-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4035090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rice, D.A.</creatorcontrib><creatorcontrib>Kennedy, S.</creatorcontrib><creatorcontrib>McMurray, C.H.</creatorcontrib><creatorcontrib>Blanchflower, W.J.</creatorcontrib><title>Experimental 3-nitro-4-hydroxyphenylarsonic acid toxicosis in pigs</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>Five times the recommended dose of 3-nitr-4-hydroxyphcnylarsonic acid (187·5 mgkg−1) induces a pathognomonic clinical syndrome in pigs. The main clinical features are not continually present but are inducible only by exercise. From day 11 on the experimental diet a nervous syndrome was inducible. This manifested as muscle tremors and clonic convulsive episodes. Paraparesis developed by day 22 and paraplegia by day 33. Liver arsenic levels plateaued at 5·4 ± 1·3 mg kg−1. The experiment confirms field observations that 3-nitro produces a characteristic toxicological syndrome, which is distinct from that of arsanilic acid. It also confirms that 3-nitro has a higher absolute toxicity than arsanilic acid in pigs as well as a tower margin of safety.</description><subject>Acids</subject><subject>Animals</subject><subject>Arsanilic Acid - poisoning</subject><subject>Arsenic</subject><subject>Arsenic - metabolism</subject><subject>Arsenic Poisoning</subject><subject>Erythema - veterinary</subject><subject>Feces - analysis</subject><subject>Kidney - metabolism</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Muscles</subject><subject>Paraplegia</subject><subject>Paraplegia - veterinary</subject><subject>Roxarsone - poisoning</subject><subject>Seizures - veterinary</subject><subject>Swine</subject><subject>Swine Diseases - metabolism</subject><subject>Swine Diseases - physiopathology</subject><subject>Syndrome - veterinary</subject><subject>Time Factors</subject><subject>Toxicity</subject><subject>Toxicosis</subject><subject>Tremors</subject><subject>Veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtrGzEURkVpcJ00P8EwUCjJQomuHqPRqrQmLzBkkWYtxpo7tcx4NJXGwf73UWKTRTdd3cV37usQMgN2BQzK6yfGhKSKV9UFVJcCdGmo_kSmoASnvCzhM5l-IF_IaUprxpgE0BMykUwoZtiU_LrZDRj9Bvux7gpBez_GQCVd7ZsYdvthhf2-q2MKvXdF7XxTjGHnXUg-Fb4vBv8nfSUnbd0lPD_WM_J8e_N7fk8Xj3cP858L6iSYkTrFsAU0olJCK60Fx2UN3JTOcFW6ClTTOIMGhWodb81SKgE1ipI7qcr8yRn5fpg7xPB3i2m0G58cdl3dY9gmC1JVrDKQwW__gOuwjX2-zfK8UGrNlMqUOlAuhpQitnbIHuq4t8Dsm2H7bti-6bNQ2XfDVue-2XH6drnB5qPrqDTnPw45ZhcvHqNNzmPvsPER3Wib4P-z4RU33Ylq</recordid><startdate>198507</startdate><enddate>198507</enddate><creator>Rice, D.A.</creator><creator>Kennedy, S.</creator><creator>McMurray, C.H.</creator><creator>Blanchflower, W.J.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>198507</creationdate><title>Experimental 3-nitro-4-hydroxyphenylarsonic acid toxicosis in pigs</title><author>Rice, D.A. ; Kennedy, S. ; McMurray, C.H. ; Blanchflower, W.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-c50ef1e93853757732eba1296c9256c815ddc9e9e35fc2f9b4531ae362c456003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Acids</topic><topic>Animals</topic><topic>Arsanilic Acid - poisoning</topic><topic>Arsenic</topic><topic>Arsenic - metabolism</topic><topic>Arsenic Poisoning</topic><topic>Erythema - veterinary</topic><topic>Feces - analysis</topic><topic>Kidney - metabolism</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Muscles</topic><topic>Paraplegia</topic><topic>Paraplegia - veterinary</topic><topic>Roxarsone - poisoning</topic><topic>Seizures - veterinary</topic><topic>Swine</topic><topic>Swine Diseases - metabolism</topic><topic>Swine Diseases - physiopathology</topic><topic>Syndrome - veterinary</topic><topic>Time Factors</topic><topic>Toxicity</topic><topic>Toxicosis</topic><topic>Tremors</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rice, D.A.</creatorcontrib><creatorcontrib>Kennedy, S.</creatorcontrib><creatorcontrib>McMurray, C.H.</creatorcontrib><creatorcontrib>Blanchflower, W.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rice, D.A.</au><au>Kennedy, S.</au><au>McMurray, C.H.</au><au>Blanchflower, W.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental 3-nitro-4-hydroxyphenylarsonic acid toxicosis in pigs</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>1985-07</date><risdate>1985</risdate><volume>39</volume><issue>1</issue><spage>47</spage><epage>51</epage><pages>47-51</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>Five times the recommended dose of 3-nitr-4-hydroxyphcnylarsonic acid (187·5 mgkg−1) induces a pathognomonic clinical syndrome in pigs. The main clinical features are not continually present but are inducible only by exercise. From day 11 on the experimental diet a nervous syndrome was inducible. This manifested as muscle tremors and clonic convulsive episodes. Paraparesis developed by day 22 and paraplegia by day 33. Liver arsenic levels plateaued at 5·4 ± 1·3 mg kg−1. The experiment confirms field observations that 3-nitro produces a characteristic toxicological syndrome, which is distinct from that of arsanilic acid. It also confirms that 3-nitro has a higher absolute toxicity than arsanilic acid in pigs as well as a tower margin of safety.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>4035090</pmid><doi>10.1016/S0034-5288(18)31769-7</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0034-5288 |
| ispartof | Research in veterinary science, 1985-07, Vol.39 (1), p.47-51 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Acids Animals Arsanilic Acid - poisoning Arsenic Arsenic - metabolism Arsenic Poisoning Erythema - veterinary Feces - analysis Kidney - metabolism Liver Liver - metabolism Muscles Paraplegia Paraplegia - veterinary Roxarsone - poisoning Seizures - veterinary Swine Swine Diseases - metabolism Swine Diseases - physiopathology Syndrome - veterinary Time Factors Toxicity Toxicosis Tremors Veterinary medicine |
| title | Experimental 3-nitro-4-hydroxyphenylarsonic acid toxicosis in pigs |
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