Uptake, Tissue Distribution, and Fate of Inhaled Carbon Tetrachloride: Comparison of Rat, Mouse, and Hamster

Carbon tetrachloride is hepatotoxic in rats, mice, and hamsters. However, rats are less sensitive to the hepatotoxic effects of CCl4 than the other two species. The purpose of this study was to compare the uptake, tissue distribution, and elimination of CCl4 by these three rodent species. Groups of...

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Veröffentlicht in:	Inhalation toxicology 2001-03, Vol.13 (3), p.207-217
Hauptverfasser:	Benson, J M, Tibbetts, B M, Thrall, K D, Springer, D L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon Radioisotopes - metabolism Carbon Radioisotopes - urine Carbon Tetrachloride - administration & dosage Carbon Tetrachloride - pharmacokinetics Carbon Tetrachloride - urine Cricetinae Inhalation Exposure Liver - drug effects Liver - metabolism Mesocricetus Mice Rats Rats, Inbred F344 Time Factors Tissue Distribution
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