Enhanced radiotolerance to ionizing radiation is correlated with increased cancer proneness of cultured fibroblasts from precursor states in neurofibromatosis patients
We have determined the sensitivity to gamma rays of cultured fibroblasts derived from clinically defined areas on the skin of neurofibromatosis patients. Fibroblasts from skin of normal appearance were normally sensitive to gamma irradiation. Significantly, however, fibroblasts from café-au-lait les...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 1986-07, Vol.22 (3), p.203-210 |
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| creator | Kopelovich, Levy Rich, Robert F. |
| description | We have determined the sensitivity to gamma rays of cultured fibroblasts derived from clinically defined areas on the skin of neurofibromatosis patients. Fibroblasts from skin of normal appearance were normally sensitive to gamma irradiation. Significantly, however, fibroblasts from café-au-lait lesions and from neurofibromas were abnormally radiotolerant (about twofold) to treatment with gamma rays. This was seen in specimens taken from the same patient, as well as from different patients, within four different neurofibromatosis pedigrees. In contrast, no differences in radiosensitivity have been observed between fibroblasts derived from skin of normal appearance and those obtained from melanotic freckles of individuals with no family history of cancer. The results suggest that increased propensity to cancer in this cell system is associated with increased radiotolerance to ionizing radiation. |
| doi_str_mv | 10.1016/0165-4608(86)90156-1 |
| format | Article |
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Fibroblasts from skin of normal appearance were normally sensitive to gamma irradiation. Significantly, however, fibroblasts from café-au-lait lesions and from neurofibromas were abnormally radiotolerant (about twofold) to treatment with gamma rays. This was seen in specimens taken from the same patient, as well as from different patients, within four different neurofibromatosis pedigrees. In contrast, no differences in radiosensitivity have been observed between fibroblasts derived from skin of normal appearance and those obtained from melanotic freckles of individuals with no family history of cancer. The results suggest that increased propensity to cancer in this cell system is associated with increased radiotolerance to ionizing radiation.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/0165-4608(86)90156-1</identifier><identifier>PMID: 3085915</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Cell Survival - radiation effects ; Cells, Cultured ; Child ; Disease Susceptibility ; Dose-Response Relationship, Radiation ; Female ; Fibroblasts - radiation effects ; Gamma Rays ; Humans ; Male ; Medical sciences ; Middle Aged ; Neoplasms, Radiation-Induced - genetics ; Neoplasms, Radiation-Induced - pathology ; Neurofibromatosis 1 - etiology ; Neurofibromatosis 1 - genetics ; Neurofibromatosis 1 - pathology ; Pedigree ; Physical agents ; Radiation Tolerance ; Tumors</subject><ispartof>Cancer genetics and cytogenetics, 1986-07, Vol.22 (3), p.203-210</ispartof><rights>1986</rights><rights>1986 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-e7729a970c9368ac0092fd1252efb3b5281b78850867859a8ce432682ebd98a63</citedby><cites>FETCH-LOGICAL-c417t-e7729a970c9368ac0092fd1252efb3b5281b78850867859a8ce432682ebd98a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0165460886901561$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8770438$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3085915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kopelovich, Levy</creatorcontrib><creatorcontrib>Rich, Robert F.</creatorcontrib><title>Enhanced radiotolerance to ionizing radiation is correlated with increased cancer proneness of cultured fibroblasts from precursor states in neurofibromatosis patients</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>We have determined the sensitivity to gamma rays of cultured fibroblasts derived from clinically defined areas on the skin of neurofibromatosis patients. Fibroblasts from skin of normal appearance were normally sensitive to gamma irradiation. Significantly, however, fibroblasts from café-au-lait lesions and from neurofibromas were abnormally radiotolerant (about twofold) to treatment with gamma rays. This was seen in specimens taken from the same patient, as well as from different patients, within four different neurofibromatosis pedigrees. In contrast, no differences in radiosensitivity have been observed between fibroblasts derived from skin of normal appearance and those obtained from melanotic freckles of individuals with no family history of cancer. The results suggest that increased propensity to cancer in this cell system is associated with increased radiotolerance to ionizing radiation.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Cell Survival - radiation effects</subject><subject>Cells, Cultured</subject><subject>Child</subject><subject>Disease Susceptibility</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Female</subject><subject>Fibroblasts - radiation effects</subject><subject>Gamma Rays</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms, Radiation-Induced - genetics</subject><subject>Neoplasms, Radiation-Induced - pathology</subject><subject>Neurofibromatosis 1 - etiology</subject><subject>Neurofibromatosis 1 - genetics</subject><subject>Neurofibromatosis 1 - pathology</subject><subject>Pedigree</subject><subject>Physical agents</subject><subject>Radiation Tolerance</subject><subject>Tumors</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU2L1TAUDaKMb0b_gUIWIrqoJm2TphtBhhkVBtzoOqTprRNpk2duqugf8m96-97jLV2EcDkfNzmHsWdSvJFC6rd0VNVqYV4Z_boXUulKPmA7abqmalulH7LdmfKYXSJ-F0J0da8v2EUjjOql2rG_N_HeRQ8jz24MqaQZ8jbzknhIMfwJ8dsBcoVGHpD7lDPMrpDkVyj3PESfwSGNfhNmvs8pQgREnibu17msmcApDDkNs8OCfMppIRr4NWPKHAu5IRnxCGtOB-biSkLatqe9EAs-YY8mNyM8Pd1X7OvtzZfrj9Xd5w-frt_fVb6VXamgow-6vhO-b7RxXoi-nkZZqxqmoRlUbeTQGaOE0R0l4IyHtqm1qWEYe-N0c8VeHn3pFz9WwGKXgB7m2UVIK1rZqrZR0hCxPRJ9TogZJrvPYXH5t5XCbv3YLXy7hW-Ntod-rCTZ85P_OiwwnkWnQgh_ccIdejdPWxkBzzTTdaJttu3vjjSgLH4GyBY95UQ9Boq12DGF_7_jHzk4sK4</recordid><startdate>19860701</startdate><enddate>19860701</enddate><creator>Kopelovich, Levy</creator><creator>Rich, Robert F.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19860701</creationdate><title>Enhanced radiotolerance to ionizing radiation is correlated with increased cancer proneness of cultured fibroblasts from precursor states in neurofibromatosis patients</title><author>Kopelovich, Levy ; Rich, Robert F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-e7729a970c9368ac0092fd1252efb3b5281b78850867859a8ce432682ebd98a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Cell Survival - radiation effects</topic><topic>Cells, Cultured</topic><topic>Child</topic><topic>Disease Susceptibility</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Female</topic><topic>Fibroblasts - radiation effects</topic><topic>Gamma Rays</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasms, Radiation-Induced - genetics</topic><topic>Neoplasms, Radiation-Induced - pathology</topic><topic>Neurofibromatosis 1 - etiology</topic><topic>Neurofibromatosis 1 - genetics</topic><topic>Neurofibromatosis 1 - pathology</topic><topic>Pedigree</topic><topic>Physical agents</topic><topic>Radiation Tolerance</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Kopelovich, Levy</creatorcontrib><creatorcontrib>Rich, Robert F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kopelovich, Levy</au><au>Rich, Robert F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced radiotolerance to ionizing radiation is correlated with increased cancer proneness of cultured fibroblasts from precursor states in neurofibromatosis patients</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1986-07-01</date><risdate>1986</risdate><volume>22</volume><issue>3</issue><spage>203</spage><epage>210</epage><pages>203-210</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>We have determined the sensitivity to gamma rays of cultured fibroblasts derived from clinically defined areas on the skin of neurofibromatosis patients. Fibroblasts from skin of normal appearance were normally sensitive to gamma irradiation. Significantly, however, fibroblasts from café-au-lait lesions and from neurofibromas were abnormally radiotolerant (about twofold) to treatment with gamma rays. This was seen in specimens taken from the same patient, as well as from different patients, within four different neurofibromatosis pedigrees. In contrast, no differences in radiosensitivity have been observed between fibroblasts derived from skin of normal appearance and those obtained from melanotic freckles of individuals with no family history of cancer. The results suggest that increased propensity to cancer in this cell system is associated with increased radiotolerance to ionizing radiation.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3085915</pmid><doi>10.1016/0165-4608(86)90156-1</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0165-4608 |
| ispartof | Cancer genetics and cytogenetics, 1986-07, Vol.22 (3), p.203-210 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell Survival - radiation effects Cells, Cultured Child Disease Susceptibility Dose-Response Relationship, Radiation Female Fibroblasts - radiation effects Gamma Rays Humans Male Medical sciences Middle Aged Neoplasms, Radiation-Induced - genetics Neoplasms, Radiation-Induced - pathology Neurofibromatosis 1 - etiology Neurofibromatosis 1 - genetics Neurofibromatosis 1 - pathology Pedigree Physical agents Radiation Tolerance Tumors |
| title | Enhanced radiotolerance to ionizing radiation is correlated with increased cancer proneness of cultured fibroblasts from precursor states in neurofibromatosis patients |
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