( super(3)H)Dihydrotetrabenazine binding to bovine striatal synaptic vesicles
(2- super(3)H)Dihydrotetrabenazine (2-hydroxy-3-isobutyl-9, 10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo(a)quinolizine) bound to a single class of binding sites in synaptic vesicles isolated from bovine corpus striatum. Dopamine, serotonin, and other substrates for transport into synaptic vesicles...
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| Veröffentlicht in: | Molecular pharmacology 1986-01, Vol.30 (3), p.252-257 |
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| container_title | Molecular pharmacology |
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| creator | Near, JA |
| description | (2- super(3)H)Dihydrotetrabenazine (2-hydroxy-3-isobutyl-9, 10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo(a)quinolizine) bound to a single class of binding sites in synaptic vesicles isolated from bovine corpus striatum. Dopamine, serotonin, and other substrates for transport into synaptic vesicles inhibited binding. The results suggest that dihydrotetrabenazine interacts with the catecholamine/serotonin porter in synaptic vesicles, although the binding site is probably not identical to that involved in active transport of substrate. |
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Dopamine, serotonin, and other substrates for transport into synaptic vesicles inhibited binding. The results suggest that dihydrotetrabenazine interacts with the catecholamine/serotonin porter in synaptic vesicles, although the binding site is probably not identical to that involved in active transport of substrate.</description><identifier>ISSN: 0026-895X</identifier><language>eng</language><subject>cattle ; dihydrotetrabenazine ; neostriatum ; synaptic vesicles</subject><ispartof>Molecular pharmacology, 1986-01, Vol.30 (3), p.252-257</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Near, JA</creatorcontrib><title>( super(3)H)Dihydrotetrabenazine binding to bovine striatal synaptic vesicles</title><title>Molecular pharmacology</title><description>(2- super(3)H)Dihydrotetrabenazine (2-hydroxy-3-isobutyl-9, 10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo(a)quinolizine) bound to a single class of binding sites in synaptic vesicles isolated from bovine corpus striatum. Dopamine, serotonin, and other substrates for transport into synaptic vesicles inhibited binding. The results suggest that dihydrotetrabenazine interacts with the catecholamine/serotonin porter in synaptic vesicles, although the binding site is probably not identical to that involved in active transport of substrate.</description><subject>cattle</subject><subject>dihydrotetrabenazine</subject><subject>neostriatum</subject><subject>synaptic vesicles</subject><issn>0026-895X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><recordid>eNqNjrsOgjAUQDtoIj7-oZOBgaSKIM4-wuLm4EYKXPWa2tbeQoJfryZ-gNNJTs5wBiwQYpnF-SY9j9iY6C7EYpXmImDHkFNrwYVJVEQ7vPWNMx68kxVo-UINvELdoL5yb3hluq8h71B6qTj1WlqPNe-AsFZAUza8SEUw-3HC5of9aVvE1plnC-TLB1INSkkNpqXyM5FkuVgnf4dv1OpA0Q</recordid><startdate>19860101</startdate><enddate>19860101</enddate><creator>Near, JA</creator><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>19860101</creationdate><title>( super(3)H)Dihydrotetrabenazine binding to bovine striatal synaptic vesicles</title><author>Near, JA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_145368073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>cattle</topic><topic>dihydrotetrabenazine</topic><topic>neostriatum</topic><topic>synaptic vesicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Near, JA</creatorcontrib><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Molecular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Near, JA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>( super(3)H)Dihydrotetrabenazine binding to bovine striatal synaptic vesicles</atitle><jtitle>Molecular pharmacology</jtitle><date>1986-01-01</date><risdate>1986</risdate><volume>30</volume><issue>3</issue><spage>252</spage><epage>257</epage><pages>252-257</pages><issn>0026-895X</issn><abstract>(2- super(3)H)Dihydrotetrabenazine (2-hydroxy-3-isobutyl-9, 10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo(a)quinolizine) bound to a single class of binding sites in synaptic vesicles isolated from bovine corpus striatum. Dopamine, serotonin, and other substrates for transport into synaptic vesicles inhibited binding. The results suggest that dihydrotetrabenazine interacts with the catecholamine/serotonin porter in synaptic vesicles, although the binding site is probably not identical to that involved in active transport of substrate.</abstract></addata></record> |
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| ispartof | Molecular pharmacology, 1986-01, Vol.30 (3), p.252-257 |
| issn | 0026-895X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14536807 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | cattle dihydrotetrabenazine neostriatum synaptic vesicles |
| title | ( super(3)H)Dihydrotetrabenazine binding to bovine striatal synaptic vesicles |
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