Biological properties of Pyrularia thionin prepared from nuts of Pyrularia pubera
Pyrularia thionin is a 47 amino acid basic peptide which resembles wheat purothionin and mistletoe viscotoxin. It is toxic to mice, with an ld 50 of 1.5 mg/kg body weight and is cytotoxic to tumor and normal cells in culture, with id 50 values ranging from 0.62 to 17 μg/ml. Against seven bacterial s...
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| Veröffentlicht in: | Toxicon (Oxford) 1986, Vol.24 (6), p.622-625 |
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| container_title | Toxicon (Oxford) |
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| creator | Evett, Gary E. Donaldson, David M. Vernon, Leo P. |
| description | Pyrularia thionin is a 47 amino acid basic peptide which resembles wheat purothionin and mistletoe viscotoxin. It is toxic to mice, with an
ld
50 of 1.5 mg/kg body weight and is cytotoxic to tumor and normal cells in culture, with
id
50 values ranging from 0.62 to 17 μg/ml. Against seven bacterial species it was toxic only to
Micrococcus luteus. The toxin did not protect mice against transplanted B16 melanoma, nor did it show any mitogenic activity with mouse spleen lymphocytes. |
| doi_str_mv | 10.1016/0041-0101(86)90185-6 |
| format | Article |
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ld
50 of 1.5 mg/kg body weight and is cytotoxic to tumor and normal cells in culture, with
id
50 values ranging from 0.62 to 17 μg/ml. Against seven bacterial species it was toxic only to
Micrococcus luteus. The toxin did not protect mice against transplanted B16 melanoma, nor did it show any mitogenic activity with mouse spleen lymphocytes.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/0041-0101(86)90185-6</identifier><identifier>PMID: 3750350</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Antimicrobial Cationic Peptides ; Antineoplastic Agents, Phytogenic ; bacteria ; Biological and medical sciences ; Cell Line ; Cytotoxins ; Hemolysis - drug effects ; Lymphocytes - drug effects ; Male ; Medical sciences ; Melanoma - drug therapy ; Mice ; Mice, Inbred C57BL ; Micrococcus - drug effects ; Mitogens ; nuts ; Plant poisons toxicology ; Plant Proteins - pharmacology ; Plant Proteins - toxicity ; proteins ; Pyrularia pubera ; Toxicology</subject><ispartof>Toxicon (Oxford), 1986, Vol.24 (6), p.622-625</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-7a0ff158446817fb95ad5c885b8ebc471e7cad070ce8ca73f37eabaa675c28d43</citedby><cites>FETCH-LOGICAL-c417t-7a0ff158446817fb95ad5c885b8ebc471e7cad070ce8ca73f37eabaa675c28d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0041-0101(86)90185-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7892988$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3750350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Evett, Gary E.</creatorcontrib><creatorcontrib>Donaldson, David M.</creatorcontrib><creatorcontrib>Vernon, Leo P.</creatorcontrib><title>Biological properties of Pyrularia thionin prepared from nuts of Pyrularia pubera</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>Pyrularia thionin is a 47 amino acid basic peptide which resembles wheat purothionin and mistletoe viscotoxin. It is toxic to mice, with an
ld
50 of 1.5 mg/kg body weight and is cytotoxic to tumor and normal cells in culture, with
id
50 values ranging from 0.62 to 17 μg/ml. Against seven bacterial species it was toxic only to
Micrococcus luteus. The toxin did not protect mice against transplanted B16 melanoma, nor did it show any mitogenic activity with mouse spleen lymphocytes.</description><subject>Animals</subject><subject>Antimicrobial Cationic Peptides</subject><subject>Antineoplastic Agents, Phytogenic</subject><subject>bacteria</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cytotoxins</subject><subject>Hemolysis - drug effects</subject><subject>Lymphocytes - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma - drug therapy</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Micrococcus - drug effects</subject><subject>Mitogens</subject><subject>nuts</subject><subject>Plant poisons toxicology</subject><subject>Plant Proteins - pharmacology</subject><subject>Plant Proteins - toxicity</subject><subject>proteins</subject><subject>Pyrularia pubera</subject><subject>Toxicology</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMouq7-A4UeRPRQTWzz0Yug4hcIKug5TNOJRrpNTVrBf2_WXfbgwdMMvM87DA8he4yeMMrEKaUly2laj5Q4rihTPBdrZMKUrPKCcbpOJitki2zH-EEpLVQlNslmITktOJ2Q50vnW__mDLRZH3yPYXAYM2-zp-8wthAcZMO7853rUo49BGwyG_ws68bhD9ePNQbYIRsW2oi7yzklrzfXL1d3-cPj7f3VxUNuSiaHXAK1lnFVlkIxaeuKQ8ONUrxWWJtSMpQGGiqpQWVAFraQCDWAkNycqaYspuRwcTe9_TliHPTMRYNtCx36MWpW8kIIViWwXIAm-BgDWt0HN4PwrRnVc5N6rknPNWkl9K9JLVJtf3l_rGfYrEpLdSk_WOYQkz0boDMurjCpqrNKqYSdLzBMLr4cBh2Nw85g4wKaQTfe_f_HDxeQkBk</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Evett, Gary E.</creator><creator>Donaldson, David M.</creator><creator>Vernon, Leo P.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1986</creationdate><title>Biological properties of Pyrularia thionin prepared from nuts of Pyrularia pubera</title><author>Evett, Gary E. ; Donaldson, David M. ; Vernon, Leo P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-7a0ff158446817fb95ad5c885b8ebc471e7cad070ce8ca73f37eabaa675c28d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Antimicrobial Cationic Peptides</topic><topic>Antineoplastic Agents, Phytogenic</topic><topic>bacteria</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cytotoxins</topic><topic>Hemolysis - drug effects</topic><topic>Lymphocytes - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanoma - drug therapy</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Micrococcus - drug effects</topic><topic>Mitogens</topic><topic>nuts</topic><topic>Plant poisons toxicology</topic><topic>Plant Proteins - pharmacology</topic><topic>Plant Proteins - toxicity</topic><topic>proteins</topic><topic>Pyrularia pubera</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Evett, Gary E.</creatorcontrib><creatorcontrib>Donaldson, David M.</creatorcontrib><creatorcontrib>Vernon, Leo P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Evett, Gary E.</au><au>Donaldson, David M.</au><au>Vernon, Leo P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological properties of Pyrularia thionin prepared from nuts of Pyrularia pubera</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>1986</date><risdate>1986</risdate><volume>24</volume><issue>6</issue><spage>622</spage><epage>625</epage><pages>622-625</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>Pyrularia thionin is a 47 amino acid basic peptide which resembles wheat purothionin and mistletoe viscotoxin. It is toxic to mice, with an
ld
50 of 1.5 mg/kg body weight and is cytotoxic to tumor and normal cells in culture, with
id
50 values ranging from 0.62 to 17 μg/ml. Against seven bacterial species it was toxic only to
Micrococcus luteus. The toxin did not protect mice against transplanted B16 melanoma, nor did it show any mitogenic activity with mouse spleen lymphocytes.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>3750350</pmid><doi>10.1016/0041-0101(86)90185-6</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-0101 |
| ispartof | Toxicon (Oxford), 1986, Vol.24 (6), p.622-625 |
| issn | 0041-0101 1879-3150 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14536619 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antimicrobial Cationic Peptides Antineoplastic Agents, Phytogenic bacteria Biological and medical sciences Cell Line Cytotoxins Hemolysis - drug effects Lymphocytes - drug effects Male Medical sciences Melanoma - drug therapy Mice Mice, Inbred C57BL Micrococcus - drug effects Mitogens nuts Plant poisons toxicology Plant Proteins - pharmacology Plant Proteins - toxicity proteins Pyrularia pubera Toxicology |
| title | Biological properties of Pyrularia thionin prepared from nuts of Pyrularia pubera |
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