Inhibition of metabolic cooperation in Chinese hamster lung fibroblast cells (V79) in culture by various DDT-analogs
An in vitro assay measuring inhibition of metabolic cooperation in Chinese hamster lung fibroblast cells (V79) was used to investigate the effects of DDT and five DDT analogs (dicofol, chlorobenzilate, bromopropylate, chloropropylate and fenarimol). These compounds were studied primarily because of...
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| Veröffentlicht in: | Archives of environmental contamination and toxicology 1985-09, Vol.14 (5), p.541-546 |
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| container_title | Archives of environmental contamination and toxicology |
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| creator | Warngard, L Flodstrom, S Ljungquist, S Ahlborg, U.G |
| description | An in vitro assay measuring inhibition of metabolic cooperation in Chinese hamster lung fibroblast cells (V79) was used to investigate the effects of DDT and five DDT analogs (dicofol, chlorobenzilate, bromopropylate, chloropropylate and fenarimol). These compounds were studied primarily because of the nongenotoxic but simultaneously carcinogenic properties of DDT and its analogs (chlorobenzilate and dicofol) and, secondly, to investigate how variations in the metabolic cooperation of hamster cells could be related to the chemical structure of the compounds. The results clearly demonstrate that all tested pesticides influenced the metabolic cooperation in a dose-dependent manner. The weak response of fenarimol suggests that sterical hindrance might influence the inhibition of metabolic cooperation. |
| doi_str_mv | 10.1007/BF01055383 |
| format | Article |
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These compounds were studied primarily because of the nongenotoxic but simultaneously carcinogenic properties of DDT and its analogs (chlorobenzilate and dicofol) and, secondly, to investigate how variations in the metabolic cooperation of hamster cells could be related to the chemical structure of the compounds. The results clearly demonstrate that all tested pesticides influenced the metabolic cooperation in a dose-dependent manner. 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These compounds were studied primarily because of the nongenotoxic but simultaneously carcinogenic properties of DDT and its analogs (chlorobenzilate and dicofol) and, secondly, to investigate how variations in the metabolic cooperation of hamster cells could be related to the chemical structure of the compounds. The results clearly demonstrate that all tested pesticides influenced the metabolic cooperation in a dose-dependent manner. The weak response of fenarimol suggests that sterical hindrance might influence the inhibition of metabolic cooperation.</description><subject>Animals</subject><subject>ANTIMETABOLITE</subject><subject>ANTIMETABOLITES</subject><subject>ANTIMETABOLITOS</subject><subject>Biological and medical sciences</subject><subject>CARCINOGENESIS</subject><subject>Carcinogens</subject><subject>Cell Line</subject><subject>Cricetinae</subject><subject>Cricetulus</subject><subject>CULTIVO DE TEJIDOS</subject><subject>CULTURE DE TISSUS</subject><subject>DDT</subject><subject>DDT - analogs & derivatives</subject><subject>DDT - pharmacology</subject><subject>FIBROBLASTE</subject><subject>FIBROBLASTOS</subject><subject>FIBROBLASTS</subject><subject>HAMSTER</subject><subject>HAMSTERS</subject><subject>Lung</subject><subject>Medical sciences</subject><subject>Metabolism - drug effects</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>TISSUE CULTURE</subject><subject>Toxicology</subject><issn>0090-4341</issn><issn>1432-0703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLHDEUxkOp6Lr20mOhkIOUWhibN8nMZI52rVYQPKi9Di_ZZDeSmazJjOB_b7a72NM7fD--9-Mj5DOwc2Cs-fnrigGrKi75BzIDwcuCNYx_JDPGWlYILuCIHKf0xBiUUopDcihYBVXdzMh4M6ydcqMLAw2W9mZEFbzTVIewMRH_BW6gi7UbTDJ0jX0aTaR-GlbUOhWD8phGqo33iX7_27RnW1xPfpyioeqVvmB0YUr08vKhwAF9WKUTcmDRJ_Npf-fk8er3w-JPcXt3fbO4uC00r2EslG4ANNeilWg1yqWVJTDJlUCxrEqRr6wZB14veVPzymrRlAK0glZLWQk-J992vZsYnieTxq53aWuKg8lKHYjcUubZ5uTHDtQxpBSN7TbR9RhfO2DdduLu_8QZ_rpvnVRvlu_oftOcn-5zTBq9jThol96xrFy1sP35ZYdZDB2uYkYe72WdnaTkb92aijw</recordid><startdate>198509</startdate><enddate>198509</enddate><creator>Warngard, L</creator><creator>Flodstrom, S</creator><creator>Ljungquist, S</creator><creator>Ahlborg, U.G</creator><general>Springer-Verlag</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>198509</creationdate><title>Inhibition of metabolic cooperation in Chinese hamster lung fibroblast cells (V79) in culture by various DDT-analogs</title><author>Warngard, L ; Flodstrom, S ; Ljungquist, S ; Ahlborg, U.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-bc711c3c498afca8df821083b4a4d524b4a8603136d37635fc47241cb19c88543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>ANTIMETABOLITE</topic><topic>ANTIMETABOLITES</topic><topic>ANTIMETABOLITOS</topic><topic>Biological and medical sciences</topic><topic>CARCINOGENESIS</topic><topic>Carcinogens</topic><topic>Cell Line</topic><topic>Cricetinae</topic><topic>Cricetulus</topic><topic>CULTIVO DE TEJIDOS</topic><topic>CULTURE DE TISSUS</topic><topic>DDT</topic><topic>DDT - analogs & derivatives</topic><topic>DDT - pharmacology</topic><topic>FIBROBLASTE</topic><topic>FIBROBLASTOS</topic><topic>FIBROBLASTS</topic><topic>HAMSTER</topic><topic>HAMSTERS</topic><topic>Lung</topic><topic>Medical sciences</topic><topic>Metabolism - drug effects</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>TISSUE CULTURE</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Warngard, L</creatorcontrib><creatorcontrib>Flodstrom, S</creatorcontrib><creatorcontrib>Ljungquist, S</creatorcontrib><creatorcontrib>Ahlborg, U.G</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Archives of environmental contamination and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Warngard, L</au><au>Flodstrom, S</au><au>Ljungquist, S</au><au>Ahlborg, U.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of metabolic cooperation in Chinese hamster lung fibroblast cells (V79) in culture by various DDT-analogs</atitle><jtitle>Archives of environmental contamination and toxicology</jtitle><addtitle>Arch Environ Contam Toxicol</addtitle><date>1985-09</date><risdate>1985</risdate><volume>14</volume><issue>5</issue><spage>541</spage><epage>546</epage><pages>541-546</pages><issn>0090-4341</issn><eissn>1432-0703</eissn><coden>AECTCV</coden><abstract>An in vitro assay measuring inhibition of metabolic cooperation in Chinese hamster lung fibroblast cells (V79) was used to investigate the effects of DDT and five DDT analogs (dicofol, chlorobenzilate, bromopropylate, chloropropylate and fenarimol). These compounds were studied primarily because of the nongenotoxic but simultaneously carcinogenic properties of DDT and its analogs (chlorobenzilate and dicofol) and, secondly, to investigate how variations in the metabolic cooperation of hamster cells could be related to the chemical structure of the compounds. The results clearly demonstrate that all tested pesticides influenced the metabolic cooperation in a dose-dependent manner. The weak response of fenarimol suggests that sterical hindrance might influence the inhibition of metabolic cooperation.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer-Verlag</pub><pmid>4051567</pmid><doi>10.1007/BF01055383</doi><tpages>6</tpages></addata></record> |
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| ispartof | Archives of environmental contamination and toxicology, 1985-09, Vol.14 (5), p.541-546 |
| issn | 0090-4341 1432-0703 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals ANTIMETABOLITE ANTIMETABOLITES ANTIMETABOLITOS Biological and medical sciences CARCINOGENESIS Carcinogens Cell Line Cricetinae Cricetulus CULTIVO DE TEJIDOS CULTURE DE TISSUS DDT DDT - analogs & derivatives DDT - pharmacology FIBROBLASTE FIBROBLASTOS FIBROBLASTS HAMSTER HAMSTERS Lung Medical sciences Metabolism - drug effects Pesticides, fertilizers and other agrochemicals toxicology TISSUE CULTURE Toxicology |
| title | Inhibition of metabolic cooperation in Chinese hamster lung fibroblast cells (V79) in culture by various DDT-analogs |
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